Beta-AflatremCAS# 144446-23-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 144446-23-1 | SDF | Download SDF |
| PubChem ID | 90659015 | Appearance | Powder |
| Formula | C32H39NO4 | M.Wt | 501.66 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1S,4R,5S,16S,19S,23R)-19-hydroxy-4,5,24,24-tetramethyl-11-(2-methylbut-3-en-2-yl)-25,26-dioxa-7-azaheptacyclo[21.2.1.01,20.04,19.05,16.06,14.08,13]hexacosa-6(14),8(13),9,11,20-pentaen-22-one | ||
| SMILES | CC1(C2C(=O)C=C3C4(CCC5CC6=C(C5(C4(CCC3(O2)O1)C)C)NC7=C6C=C(C=C7)C(C)(C)C=C)O)C | ||
| Standard InChIKey | ONMXSHAELZXSPO-SDPXOEJRSA-N | ||
| Standard InChI | InChI=1S/C32H39NO4/c1-8-27(2,3)18-9-10-22-20(15-18)21-16-19-11-12-31(35)24-17-23(34)26-28(4,5)37-32(24,36-26)14-13-29(31,6)30(19,7)25(21)33-22/h8-10,15,17,19,26,33,35H,1,11-14,16H2,2-7H3/t19-,26-,29+,30+,31+,32-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Standard reference |
| In vitro | Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.[Pubmed: 24983640 ]Mar Drugs. 2014 Jun 30;12(7):3970-81.
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Beta-Aflatrem Dilution Calculator
Beta-Aflatrem Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9934 mL | 9.9669 mL | 19.9338 mL | 39.8676 mL | 49.8345 mL |
| 5 mM | 0.3987 mL | 1.9934 mL | 3.9868 mL | 7.9735 mL | 9.9669 mL |
| 10 mM | 0.1993 mL | 0.9967 mL | 1.9934 mL | 3.9868 mL | 4.9835 mL |
| 50 mM | 0.0399 mL | 0.1993 mL | 0.3987 mL | 0.7974 mL | 0.9967 mL |
| 100 mM | 0.0199 mL | 0.0997 mL | 0.1993 mL | 0.3987 mL | 0.4983 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.[Pubmed:24983640]
Mar Drugs. 2014 Jun 30;12(7):3970-81.
Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known Beta-Aflatrem (4), paspalinine (5), leporin B (6), alpha-cyclopiazonic acid (7), iso-alpha-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation broth of the marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures of Compounds 1-12 were elucidated by spectroscopic analyses, quantum ECD calculations and the chemical method. New Compound 1 exhibited antibacterial activity against Staphylococcus aureus with a MIC value of 20.5 muM. Both new Compounds 1 and 2 could arrest the A549 cell cycle in the S phase at a concentration of 10 muM. Compound 1 showed PKC-beta inhibition with an IC50 value of 15.6 muM. In addition, the absolute configurations of the known compounds, 4-6 and leporin A (6a), were also determined for the first time.
