Isorhynchophyllic acidCAS# 144525-05-3 |
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| Cas No. | 144525-05-3 | SDF | Download SDF |
| PubChem ID | 102004526 | Appearance | White cryst. |
| Formula | C21H26N2O4 | M.Wt | 370.44 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-2-[(6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoic acid | ||
| SMILES | CCC1CN2CCC3(C2CC1C(=COC)C(=O)O)C4=CC=CC=C4NC3=O | ||
| Standard InChIKey | IQSFEAHJUMVILC-LAYNFGILSA-N | ||
| Standard InChI | InChI=1S/C21H26N2O4/c1-3-13-11-23-9-8-21(16-6-4-5-7-17(16)22-20(21)26)18(23)10-14(13)15(12-27-2)19(24)25/h4-7,12-14,18H,3,8-11H2,1-2H3,(H,22,26)(H,24,25)/b15-12+/t13-,14-,18-,21?/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Uncaria rhynchophylla.
| Description | 1. Isorhynchophyllic acid can significantly inhibit the proliferation of human cancer cells(A549, HepG2 and A2780 cells) with IC50 values being 5.8, 12.8 and 11.8 umol/L, respectively. |
Isorhynchophyllic acid Dilution Calculator
Isorhynchophyllic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6995 mL | 13.4975 mL | 26.9949 mL | 53.9898 mL | 67.4873 mL |
| 5 mM | 0.5399 mL | 2.6995 mL | 5.399 mL | 10.798 mL | 13.4975 mL |
| 10 mM | 0.2699 mL | 1.3497 mL | 2.6995 mL | 5.399 mL | 6.7487 mL |
| 50 mM | 0.054 mL | 0.2699 mL | 0.5399 mL | 1.0798 mL | 1.3497 mL |
| 100 mM | 0.027 mL | 0.135 mL | 0.2699 mL | 0.5399 mL | 0.6749 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Two new ortho benzoquinones from Uncaria rhynchophylla.[Pubmed:27025371]
Chin J Nat Med. 2016 Mar;14(3):232-5.
The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH2Cl2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone (1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone (2), together with a known compound Isorhynchophyllic acid (3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, HepG2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, HepG2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, HepG2 and A2780 cells with IC50 values being 5.8, 12.8 and 11.8 micromol.L(-1), respectively.
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