IRL-1038ETB antagonist CAS# 144602-02-8 |
- Gatifloxacin
Catalog No.:BCC1064
CAS No.:112811-59-3
- Dexrazoxane HCl (ICRF-187, ADR-529)
Catalog No.:BCC1087
CAS No.:149003-01-0
- Doxorubicin (Adriamycin) HCl
Catalog No.:BCC1117
CAS No.:25316-40-9
- Etoposide
Catalog No.:BCC1151
CAS No.:33419-42-0
- Genistein
Catalog No.:BCN5499
CAS No.:446-72-0
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 144602-02-8 | SDF | Download SDF |
| PubChem ID | 16130960 | Appearance | Powder |
| Formula | C68H92N14O15S2 | M.Wt | 1409.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 1 mg/ml in 20% acetonitrile | ||
| Sequence | CVYFCHLDIIW (Modifications: Disulfide bridge between 1 - 5) | ||
| Chemical Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(7S,13S,16R)-16-amino-7-benzyl-10-[(4-hydroxyphenyl)methyl]-6,9,12,15-tetraoxo-13-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | ||
| SMILES | CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC3=CN=CN3)NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)CC5=CC=CC=C5)CC6=CC=C(C=C6)O)C(C)C)N | ||
| Standard InChIKey | OETKRDJJNWJFOP-PFAVPODXSA-N | ||
| Standard InChI | InChI=1S/C68H92N14O15S2/c1-9-37(7)56(66(94)78-52(68(96)97)27-41-30-71-46-19-15-14-18-44(41)46)82-67(95)57(38(8)10-2)81-63(91)51(29-54(84)85)76-59(87)47(24-35(3)4)73-62(90)50(28-42-31-70-34-72-42)75-64(92)53-33-99-98-32-45(69)58(86)80-55(36(5)6)65(93)77-49(26-40-20-22-43(83)23-21-40)60(88)74-48(61(89)79-53)25-39-16-12-11-13-17-39/h11-23,30-31,34-38,45,47-53,55-57,71,83H,9-10,24-29,32-33,69H2,1-8H3,(H,70,72)(H,73,90)(H,74,88)(H,75,92)(H,76,87)(H,77,93)(H,78,94)(H,79,89)(H,80,86)(H,81,91)(H,82,95)(H,84,85)(H,96,97)/t37-,38-,45-,47-,48-,49?,50-,51-,52-,53?,55-,56-,57-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | ETB endothelin receptor antagonist. |
IRL-1038 Dilution Calculator
IRL-1038 Molarity Calculator
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Paliperidone
Catalog No.:BCC3834
CAS No.:144598-75-4
- Kanshone H
Catalog No.:BCN7627
CAS No.:1445952-33-9
- GSK 2837808A
Catalog No.:BCC5607
CAS No.:1445879-21-9
- ME0328
Catalog No.:BCC3995
CAS No.:1445251-22-8
- Murrayanol
Catalog No.:BCN3178
CAS No.:144525-81-5
- Oxyresveratrol 3'-O-beta-D-glucopyranoside
Catalog No.:BCN1566
CAS No.:144525-40-6
- Isorhynchophyllic acid
Catalog No.:BCN4980
CAS No.:144525-05-3
- Pixantrone
Catalog No.:BCC5222
CAS No.:144510-96-3
- Cannabisin D
Catalog No.:BCN2547
CAS No.:144506-19-4
- Rotundatin
Catalog No.:BCN7856
CAS No.:144506-16-1
- Licochalcone C
Catalog No.:BCN6334
CAS No.:144506-14-9
- Tirofiban
Catalog No.:BCC4868
CAS No.:144494-65-5
- Schisanlignone C
Catalog No.:BCN3629
CAS No.:144606-83-7
- Schisanlignone D
Catalog No.:BCN3630
CAS No.:144606-84-8
- Isomahanine
Catalog No.:BCN3177
CAS No.:144606-95-1
- CPI-203
Catalog No.:BCC4099
CAS No.:1446144-04-2
- GR 113808
Catalog No.:BCC7019
CAS No.:144625-51-4
- 22-Hydroxy-3-oxoolean-12-en-29-oic acid
Catalog No.:BCN1565
CAS No.:144629-84-5
- (+)-Lyoniresinol
Catalog No.:BCN6248
CAS No.:14464-90-5
- Olmesartan
Catalog No.:BCC1819
CAS No.:144689-24-7
- Olmesartan medoxomil
Catalog No.:BCC2143
CAS No.:144689-63-4
- Hispidulin
Catalog No.:BCN6250
CAS No.:1447-88-7
- Fmoc-D-Cha-OH
Catalog No.:BCC3161
CAS No.:144701-25-7
- Telmisattan
Catalog No.:BCC3863
CAS No.:144701-48-4
An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]-endothelin-1(11-21)[Pubmed:1397285]
FEBS Lett. 1992 Oct 12;311(1):12-6.
In the inhibition of specific binding of [125I]endothelins (ETs) to membrane from various tissues of rats, guinea pigs, pigs and humans, [Cys11-Cys15]-ET-1(11-21), IRL 1038, has a much higher affinity for ETB receptors (Ki = 6-11 nM) than for ETA receptors (Ki = 0.4-0.7 microM). In contraction assays, with ET-3 as a stimulant, 3 microM IRL 1038 antagonized the ETB receptor-mediated contraction of guinea pig ileal and tracheal smooth muscle without any significant agonistic activity, but did not effect the ETA receptor-mediated contraction of rat aortic smooth muscle. IRL 1038 is therefore, considered to be the first antagonist selective to the ETB receptor.
ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation.[Pubmed:8449230]
Eur J Pharmacol. 1993 Feb 16;231(3):371-4.
In isolated rat aorta, endothelin-1 induced contractions at lower concentrations than endothelin-3. The contractile effects were augmented by removing the endothelium. In contrast, endothelium-1 and endothelin-3 at similar concentrations induced endothelium-dependent relaxation in norepinephrine-stimulated aorta. IRL 1038 ([Cys11,Cys15]endothelin-1(11-21); 3 microM) augmented the contractile effects of endothelins only in the presence of the endothelium. IRL 1038 (0.3-3 microM) inhibited the endothelium-dependent relaxation induced by endothelins but not by carbachol. IRL 1038 itself did not change muscle tension. These results suggest that IRL 1038 is a novel antagonist of the ETB receptor responsible for the release of relaxing factor from the vascular endothelium.
