Fmoc-D-Cha-OH

CAS# 144701-25-7

Fmoc-D-Cha-OH

Catalog No. BCC3161----Order now to get a substantial discount!

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Chemical structure

Fmoc-D-Cha-OH

3D structure

Chemical Properties of Fmoc-D-Cha-OH

Cas No. 144701-25-7 SDF Download SDF
PubChem ID 978327 Appearance Powder
Formula C24H27NO4 M.Wt 393.5
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
SMILES C1CCC(CC1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Standard InChIKey HIJAUEZBPWTKIV-JOCHJYFZSA-N
Standard InChI InChI=1S/C24H27NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,16,21-22H,1-3,8-9,14-15H2,(H,25,28)(H,26,27)/t22-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Fmoc-D-Cha-OH Dilution Calculator

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Fmoc-D-Cha-OH Molarity Calculator

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Preparing Stock Solutions of Fmoc-D-Cha-OH

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5413 mL 12.7065 mL 25.413 mL 50.8259 mL 63.5324 mL
5 mM 0.5083 mL 2.5413 mL 5.0826 mL 10.1652 mL 12.7065 mL
10 mM 0.2541 mL 1.2706 mL 2.5413 mL 5.0826 mL 6.3532 mL
50 mM 0.0508 mL 0.2541 mL 0.5083 mL 1.0165 mL 1.2706 mL
100 mM 0.0254 mL 0.1271 mL 0.2541 mL 0.5083 mL 0.6353 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Fmoc-D-Cha-OH

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References on Fmoc-D-Cha-OH

DR396, an apoptotic DNase gamma inhibitor, attenuates high mobility group box 1 release from apoptotic cells.[Pubmed:21167721]

Bioorg Med Chem. 2011 Jan 1;19(1):168-71.

High mobility group box1 (HMGB1) is a non-histone chromatin chromosomal protein playing an important role in chromatin architecture and transcriptional regulation. Recently, HMGB1 has been shown to be secreted into extracellular milieu in necrosis and apoptosis, and involved in inflammatory responses. However, the mechanism by which apoptotic cells release HMGB1 is unclear. In this study, to investigate the mechanism of HMGB1 release, we searched inhibitors of HMGB1 release from apoptotic cells. As a result, three compounds, 4-(4,6-dichloro-[1,3,5]-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-be nzoic acid (DR396), Pontacyl Violet 6R (PV6R), and Fmoc-D-Cha-OH (FDCO) in our in-house chemical library were found to inhibit HMGB1 release from staurosporine (STS)-induced apoptotic HeLa S3 cells. Interestingly, these three compounds have been previously categorized into apoptotic DNase gamma inhibitors. Therefore, we examined whether apoptotic nucleosomal DNA fragmentation is involved in the release of HMGB1 during apoptosis. Expectedly, DR396, which is the most potent and specific inhibitor of DNase gamma, was found to almost completely inhibit both HMGB1 release and internucleosomal DNA cleavage in HeLa S3 cells transfected with DNase gamma expression vector and stably expressing DNase gamma (HeLa S3/gamma cells). These results clearly suggest that nucleosomal DNA fragmentation catalyzed by DNase gamma is critical in the release of HMGB1 from apoptotic cells.

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