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Buddlejasaponin IVb

CAS# 152580-79-5

Buddlejasaponin IVb

Catalog No. BCN2842----Order now to get a substantial discount!

Product Name & Size Price Stock
Buddlejasaponin IVb: 5mg $17 In Stock
Buddlejasaponin IVb: 10mg Please Inquire In Stock
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Quality Control of Buddlejasaponin IVb

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Chemical structure

Buddlejasaponin IVb

3D structure

Chemical Properties of Buddlejasaponin IVb

Cas No. 152580-79-5 SDF Download SDF
PubChem ID 91758420 Appearance Powder
Formula C48H78O18 M.Wt 943.12
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-5-hydroxy-6-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC1C(C(C(C(O1)OC2CCC3(C(C2(C)CO)CCC4(C3C=CC5=C6CC(CCC6(C(CC54C)O)CO)(C)C)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)O
Standard InChIKey CXSXBHMYYCPTHP-QZXFRBLOSA-N
Standard InChI InChI=1S/C48H78O18/c1-22-31(54)38(65-40-36(59)34(57)32(55)25(18-49)62-40)39(66-41-37(60)35(58)33(56)26(19-50)63-41)42(61-22)64-30-11-12-44(4)27(45(30,5)20-51)10-13-46(6)28(44)9-8-23-24-16-43(2,3)14-15-48(24,21-52)29(53)17-47(23,46)7/h8-9,22,25-42,49-60H,10-21H2,1-7H3/t22-,25-,26-,27-,28-,29+,30+,31+,32-,33-,34+,35+,36-,37-,38+,39-,40+,41+,42+,44+,45+,46-,47-,48-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Buddlejasaponin IVb

The herbs of Clinopodium chinense

Biological Activity of Buddlejasaponin IVb

DescriptionBuddlejasaponin IVb(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy.
TargetsPAFR
In vitro

A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze.[Pubmed: 26511166 ]

Nat Prod Res. 2016;30(9):1001-8.

A new triterpene saponin, 3β,16β,23α,28β,30β-pentahydroxyl-olean-11,13(18)-dien-3β-yl-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D-fucopyranoside, was named Clinoposaponin D (1), together with six known triterpene saponins, Buddlejasaponin IVb (2), buddlejasaponin IVa (3), buddlejasaponin IV (4), clinopodisides D (5), 11α,16β,23,28-Tetrahydroxyolean-12-en-3β-yl-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D-fucopyranoside (6) and prosaikogenin A (7), and two known triterpenes, saikogenin A (8) and saikogenin F (9) were isolated from Clinopodium chinense (Benth.) O. Kuntze.
METHODS AND RESULTS:
Their structures were elucidated on the basis of 1D, 2D NMR and MS analysis. Meanwhile, the effects of all compounds on rabbit platelet aggregation and thrombin time (TT) were investigated in vitro. Compounds 4 and 7 had significant promoting effects on platelet aggregation with EC50 value at 53.4 and 12.2 μM, respectively. In addition, the highest concentration (200 μM) of compounds 2 and 9 shortened TT by 20.6 and 25.1%, respectively.

Buddlejasaponin IVb Dilution Calculator

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Buddlejasaponin IVb Molarity Calculator

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Preparing Stock Solutions of Buddlejasaponin IVb

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0603 mL 5.3016 mL 10.6031 mL 21.2062 mL 26.5078 mL
5 mM 0.2121 mL 1.0603 mL 2.1206 mL 4.2412 mL 5.3016 mL
10 mM 0.106 mL 0.5302 mL 1.0603 mL 2.1206 mL 2.6508 mL
50 mM 0.0212 mL 0.106 mL 0.2121 mL 0.4241 mL 0.5302 mL
100 mM 0.0106 mL 0.053 mL 0.106 mL 0.2121 mL 0.2651 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Buddlejasaponin IVb

A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze.[Pubmed:26511166]

Nat Prod Res. 2016;30(9):1001-8.

A new triterpene saponin, 3beta,16beta,23alpha,28beta,30beta-pentahydroxyl-olean-11,13(18)-dien-3beta-yl-[b eta-D-glucopyranosyl-(1-->2)]-[beta-D-glucopyranosyl-(1-->3)]-beta-D-fucopyranosi de, was named Clinoposaponin D (1), together with six known triterpene saponins, Buddlejasaponin IVb (2), buddlejasaponin IVa (3), buddlejasaponin IV (4), clinopodisides D (5), 11alpha,16beta,23,28-Tetrahydroxyolean-12-en-3beta-yl-[beta-D-glucopyranosyl-(1-- >2)]-[beta-D-glucopyranosyl-(1-->3)]-beta-D-fucopyranoside (6) and prosaikogenin A (7), and two known triterpenes, saikogenin A (8) and saikogenin F (9) were isolated from Clinopodium chinense (Benth.) O. Kuntze. Their structures were elucidated on the basis of 1D, 2D NMR and MS analysis. Meanwhile, the effects of all compounds on rabbit platelet aggregation and thrombin time (TT) were investigated in vitro. Compounds 4 and 7 had significant promoting effects on platelet aggregation with EC50 value at 53.4 and 12.2 muM, respectively. In addition, the highest concentration (200 muM) of compounds 2 and 9 shortened TT by 20.6 and 25.1%, respectively.

Description

Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 %.

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