Ceranib 1Ceramidase inhibitor; antiproliferative CAS# 328076-61-5 |
Related Products
- Calyculin A
Catalog No.:BCC2457
CAS No.:101932-71-2
- Fumonisin B1
Catalog No.:BCC2461
CAS No.:116355-83-0
- Calcineurin Autoinhibitory Peptide
Catalog No.:BCC2456
CAS No.:148067-21-4
- DL-AP3
Catalog No.:BCC2459
CAS No.:20263-06-3
- Fostriecin sodium salt
Catalog No.:BCC2460
CAS No.:87860-39-7
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 328076-61-5 | SDF | Download SDF |
| PubChem ID | 5761166 | Appearance | Powder |
| Formula | C26H21NO3 | M.Wt | 395.45 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | 3-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-6-methyl-4-phenyl-1H-quinolin-2-one | ||
| SMILES | CC1=CC2=C(C=C1)NC(=O)C(=C2C3=CC=CC=C3)C(=O)C=CC4=CC=C(C=C4)OC | ||
| Standard InChIKey | OJMCCNQNCSCAJV-RVDMUPIBSA-N | ||
| Standard InChI | InChI=1S/C26H21NO3/c1-17-8-14-22-21(16-17)24(19-6-4-3-5-7-19)25(26(29)27-22)23(28)15-11-18-9-12-20(30-2)13-10-18/h3-16H,1-2H3,(H,27,29)/b15-11+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells. |
Ceranib 1 Dilution Calculator
Ceranib 1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5288 mL | 12.6438 mL | 25.2876 mL | 50.5753 mL | 63.2191 mL |
| 5 mM | 0.5058 mL | 2.5288 mL | 5.0575 mL | 10.1151 mL | 12.6438 mL |
| 10 mM | 0.2529 mL | 1.2644 mL | 2.5288 mL | 5.0575 mL | 6.3219 mL |
| 50 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.0115 mL | 1.2644 mL |
| 100 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.5058 mL | 0.6322 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- H-D-Leu-OH
Catalog No.:BCC2975
CAS No.:328-38-1
- Nomifensine
Catalog No.:BCC7226
CAS No.:32795-47-4
- Panaxatriol
Catalog No.:BCN1081
CAS No.:32791-84-7
- Labetalol HCl
Catalog No.:BCC5489
CAS No.:32780-64-6
- Protopanaxatriol
Catalog No.:BCC9245
CAS No.:32773-56-1
- Macrocarpal O
Catalog No.:BCN7371
CAS No.:327622-65-1
- BIO 5192
Catalog No.:BCC8002
CAS No.:327613-57-0
- Macrocarpal L
Catalog No.:BCN5248
CAS No.:327601-97-8
- Phorbol 13-acetate
Catalog No.:BCN7231
CAS No.:32752-29-7
- Heliosupine
Catalog No.:BCN1980
CAS No.:32728-78-2
- tcY-NH2
Catalog No.:BCC5770
CAS No.:327177-34-4
- Cyclohexanecarboxylic acid
Catalog No.:BCN3443
CAS No.:98-89-5
New Products
- Phortress
Catalog No.:BCC3901
CAS No.:328087-38-3
- Coniferyl alcohol
Catalog No.:BCN4651
CAS No.:32811-40-8
- (H-Cys-OMe)2.2HCl
Catalog No.:BCC2916
CAS No.:32854-09-4
- Lannaconitine
Catalog No.:BCN2504
CAS No.:32854-75-4
- GlyH-101
Catalog No.:BCC4104
CAS No.:328541-79-3
- AG-14361
Catalog No.:BCC2209
CAS No.:328543-09-5
- Benzylamine hydrochloride
Catalog No.:BCN6908
CAS No.:3287-99-8
- Cajanin
Catalog No.:BCN5249
CAS No.:32884-36-9
- Lasiodiplodin
Catalog No.:BCN4770
CAS No.:32885-81-7
- De-O-methyllasiodiplodin
Catalog No.:BCN7187
CAS No.:32885-82-8
- Tildipirosin
Catalog No.:BCC5478
CAS No.:328898-40-4
- pep2-SVKI
Catalog No.:BCC5784
CAS No.:328944-75-8
Discovery and evaluation of inhibitors of human ceramidase.[Pubmed:21885864]
Mol Cancer Ther. 2011 Nov;10(11):2052-61.
The ceramide/sphingosine-1-phosphate (S1P) rheostat has been hypothesized to play a critical role in regulating tumor cell fate, with elevated levels of ceramide inducing death and elevated levels of S1P leading to survival and proliferation. Ceramidases are key enzymes that control this rheostat by hydrolyzing ceramide to produce sphingosine and may also confer resistance to drugs and radiation. Therefore, ceramidase inhibitors have excellent potential for development as new anticancer drugs. In this study, we identify a novel ceramidase inhibitor (Ceranib-1) by screening a small molecule library and describe the synthesis of a more potent analogue (Ceranib-2). In a cell-based assay, both compounds were found to inhibit cellular ceramidase activity toward an exogenous ceramide analogue, induce the accumulation of multiple ceramide species, decrease levels of sphingosine and S1P, inhibit the proliferation of cells alone and in combination with paclitaxel, and induce cell-cycle arrest and cell death. In vivo, Ceranib-2 was found to delay tumor growth in a syngeneic tumor model without hematologic suppression or overt signs of toxicity. These data support the selection of ceramidases as suitable targets for anticancer drug development and provide the first nonlipid inhibitors of human ceramidase activity.
Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells.
Ceranib 1,328076-61-5,Natural Products,Ceramidases, buy Ceranib 1 , Ceranib 1 supplier , purchase Ceranib 1 , Ceranib 1 cost , Ceranib 1 manufacturer , order Ceranib 1 , high purity Ceranib 1
