ChlorophorinCAS# 537-41-7 |
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| Cas No. | 537-41-7 | SDF | Download SDF |
| PubChem ID | 5281713 | Appearance | Powder |
| Formula | C24H28O4 | M.Wt | 380.5 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-[(E)-2-(2,4-dihydroxyphenyl)ethenyl]-2-[(2E)-3,7-dimethylocta-2,6-dienyl]benzene-1,3-diol | ||
| SMILES | CC(=CCCC(=CCC1=C(C=C(C=C1O)C=CC2=C(C=C(C=C2)O)O)O)C)C | ||
| Standard InChIKey | OEILZVSHVTYHKL-MZYNZGBKSA-N | ||
| Standard InChI | InChI=1S/C24H28O4/c1-16(2)5-4-6-17(3)7-12-21-23(27)13-18(14-24(21)28)8-9-19-10-11-20(25)15-22(19)26/h5,7-11,13-15,25-28H,4,6,12H2,1-3H3/b9-8+,17-7+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. 2. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM. 3. Chlorophorin can reduce tyrosinase activity and inhibit α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells. |
| Targets | Tyrosinase | Antifection |
Chlorophorin Dilution Calculator
Chlorophorin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6281 mL | 13.1406 mL | 26.2812 mL | 52.5624 mL | 65.703 mL |
| 5 mM | 0.5256 mL | 2.6281 mL | 5.2562 mL | 10.5125 mL | 13.1406 mL |
| 10 mM | 0.2628 mL | 1.3141 mL | 2.6281 mL | 5.2562 mL | 6.5703 mL |
| 50 mM | 0.0526 mL | 0.2628 mL | 0.5256 mL | 1.0512 mL | 1.3141 mL |
| 100 mM | 0.0263 mL | 0.1314 mL | 0.2628 mL | 0.5256 mL | 0.657 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The inhibitory components from Artocarpus incisus on melanin biosynthesis.[Pubmed:9690341]
Planta Med. 1998 Jun;64(5):408-12.
The inhibitory effects of methanol extracts of heartwood of 23 Papua New Guinean wood species on tyrosinase activity were examined. The extract of Artocarpus incisus showed the strongest tyrosinase inhibitory activity which was equivalent to kojic acid. The extract apparently inhibited melanin biosynthesis of both cultured B16 melanoma cells without any cytotoxicity and in the back of a brown guinea pig without skin irritation. Thus, the potentiality of the extracts of heartwood of A. incisus both as material of a useful skin whitening agent and as a remedy for disturbances in pigmentation is evident. Tyrosinase inhibitory activity-guided fractionation led to the isolation of seven active compounds including a new compound which has been characterized as 6-(3"-methyl-1"-butenyl)-5,7,2',4'-tetrahydroxyflavone, named isoartocarpesin. Other active compounds were (+)-dihydromorin, Chlorophorin, (+)-norartocarpanone, 4-prenyloxyresveratrol, artocarbene, and artocarpesin, These compounds are probably responsible for the melanin biosynthesis inhibitory effects.
Anti-amoebic activity of plant compounds from Virgilia oroboides and Chlorophora excelsa.[Pubmed:11585689]
J Ethnopharmacol. 2001 Nov;78(1):59-66.
The anti-amoebic activity of four plant extracts: maackiain and formononetin from Virgilia oroboides and Chlorophorin and Iroko from Chlorophora excelsa, were evaluated. Anti-protozoal tests conducted on trophozoites of Entamoeba histolytica established that all four compounds had an affect on the trophozoites to some degree. Chlorophorin showed the highest anti-protozoal activity with an MIC of 0.25 microg/ml followed by maackiain and Iroko with MICs of 1 microg/ml. Chlorophorin and Iroko induced the release of acid phosphatase. Chlorophorin reduced alpha amylase levels by 89%. Formononetin and maackiain had a minimal effect on the enzyme levels. Ultrastructural changes occurred in trophozoites treated with plant compounds. The degree of destruction of the trophozoites increased with an increase in compound concentration. Trophozoite destruction was initiated by the disintegration of the nucleus and culminated with the rupture of the cytoplasmic membrane. Maackiain was the only compound that showed some level of mutagenicity. Formononetin and Iroko were very slightly mutagenic, while Chlorophorin was non-mutagenic. In addition, none of the compounds tested showed cytopathic effects on any of the cell lines tested. Chlorophorin and Iroko exhibit the potential to be exploited as natural multi-functional safe control agents in the treatment of bacterial, fungal and protozoal infections.
