VindesineCAS# 53643-48-4 |
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| Cas No. | 53643-48-4 | SDF | Download SDF |
| PubChem ID | 40839 | Appearance | Cryst. |
| Formula | C43H55N5O7 | M.Wt | 753.92 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O | ||
| Standard InChIKey | HHJUWIANJFBDHT-KOTLKJBCSA-N | ||
| Standard InChI | InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Catharanthus roseus (L.) G. Don
| Description | 1. Vindesine is a microtubule inhibitor and widely used to treat malignancies. 2. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms. |
Vindesine Dilution Calculator
Vindesine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3264 mL | 6.632 mL | 13.264 mL | 26.528 mL | 33.16 mL |
| 5 mM | 0.2653 mL | 1.3264 mL | 2.6528 mL | 5.3056 mL | 6.632 mL |
| 10 mM | 0.1326 mL | 0.6632 mL | 1.3264 mL | 2.6528 mL | 3.316 mL |
| 50 mM | 0.0265 mL | 0.1326 mL | 0.2653 mL | 0.5306 mL | 0.6632 mL |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1326 mL | 0.2653 mL | 0.3316 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Vindesine-induced neuropathy mimicking Guillain-Barre syndrome.[Pubmed:19428104]
Leuk Res. 2009 Dec;33(12):e232-3.
A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including Vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barre syndrome. Spinal fluid analysis showed a normal protein level, Vindesine neuropathy seemed to be the cause of the patient's neurological symptoms. The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.
Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.[Pubmed:22246157]
J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41.
Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported. Alternative treatment containing Vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.
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