O-1918CAS# 536697-79-7 |
- Cefditoren Pivoxil
Catalog No.:BCC4898
CAS No.:117467-28-4
- Cefoselis
Catalog No.:BCC4092
CAS No.:122841-10-5
- Balofloxacin
Catalog No.:BCC4892
CAS No.:127294-70-6
- Pefloxacin Mesylate Dihydrate
Catalog No.:BCC5089
CAS No.:149676-40-4
- Tinidazole
Catalog No.:BCC4866
CAS No.:19387-91-8
- Toltrazuril
Catalog No.:BCC4870
CAS No.:69004-03-1
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 536697-79-7 | SDF | Download SDF |
| PubChem ID | 21055524 | Appearance | Powder |
| Formula | C19H26O2 | M.Wt | 286.41 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 1,3-dimethoxy-5-methyl-2-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene | ||
| SMILES | CC1=CC(C(CC1)C(=C)C)C2=C(C=C(C=C2OC)C)OC | ||
| Standard InChIKey | ICHJMVMWPKLUKT-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H26O2/c1-12(2)15-8-7-13(3)9-16(15)19-17(20-5)10-14(4)11-18(19)21-6/h9-11,15-16H,1,7-8H2,2-6H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD). |
O-1918 Dilution Calculator
O-1918 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4915 mL | 17.4575 mL | 34.915 mL | 69.83 mL | 87.2875 mL |
| 5 mM | 0.6983 mL | 3.4915 mL | 6.983 mL | 13.966 mL | 17.4575 mL |
| 10 mM | 0.3491 mL | 1.7457 mL | 3.4915 mL | 6.983 mL | 8.7287 mL |
| 50 mM | 0.0698 mL | 0.3491 mL | 0.6983 mL | 1.3966 mL | 1.7457 mL |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3491 mL | 0.6983 mL | 0.8729 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 4,6-Dimethoxy-2H-1-benzopyran-2-one
Catalog No.:BCN3452
CAS No.:53666-78-7
- Dehydrobruceantin
Catalog No.:BCN7617
CAS No.:53662-98-9
- Vindesine
Catalog No.:BCN2607
CAS No.:53643-48-4
- Teucvin
Catalog No.:BCN8375
CAS No.:53625-15-3
- GMQ hydrochloride
Catalog No.:BCC6351
CAS No.:5361-15-9
- 1-Hydroxyrutaecarpine
Catalog No.:BCN5709
CAS No.:53600-24-1
- Perillyl alcohol
Catalog No.:BCN3876
CAS No.:536-59-4
- Ethionamide
Catalog No.:BCC3778
CAS No.:536-33-4
- 5'-Iodoresiniferatoxin
Catalog No.:BCC7031
CAS No.:535974-91-5
- Secolongifolenediol
Catalog No.:BCN6989
CAS No.:53587-37-4
- H-Tyr-OBzl.TosOH
Catalog No.:BCC3124
CAS No.:53587-11-4
- 5-Galloylquinic acid
Catalog No.:BCN3060
CAS No.:53584-43-3
- ICI 89406
Catalog No.:BCC6807
CAS No.:53671-71-9
- QX 222
Catalog No.:BCC6906
CAS No.:5369-00-6
- QX 314 chloride
Catalog No.:BCC7326
CAS No.:5369-03-9
- 3-Acetyl-5-Hydroxymethyl-7-Hydroxycoumarin
Catalog No.:BCC9201
CAS No.:53696-74-5
- Diperodon HCl
Catalog No.:BCC3766
CAS No.:537-12-2
- Tropacocaine
Catalog No.:BCN1934
CAS No.:537-26-8
- Isoporoidine
Catalog No.:BCN1890
CAS No.:537-28-0
- Convolvine
Catalog No.:BCN1904
CAS No.:537-30-4
- Chlorophorin
Catalog No.:BCN3288
CAS No.:537-41-7
- Pterostilbene
Catalog No.:BCN2539
CAS No.:537-42-8
- N-Acetyl-L-tyrosine
Catalog No.:BCC9082
CAS No.:537-55-3
- Soyasaponin Be Methyl Ester
Catalog No.:BCN5925
CAS No.:117210-13-6
A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats.[Pubmed:20105178]
Br J Pharmacol. 2010 Jun;160(3):574-84.
BACKGROUND AND PURPOSE: Intravenous injection of the endocannabinoid anandamide induces complex cardiovascular changes via cannabinoid CB(1), CB(2) and vanilloid TRPV1 receptors. Recently, evidence has been accumulating that in vitro, but not in vivo, anandamide relaxes blood vessels, via an as yet unidentified, non-CB(1) vascular cannabinoid receptor, sensitive to O-1918 (1,3-dimethoxy-5-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benze ne). We here examined whether the anandamide-induced hypotension in urethane-anaesthetized rats was also mediated via a non-CB(1) vascular cannabinoid receptor. EXPERIMENTAL APPROACH: Effects of two antagonists (O-1918 and cannabidiol) of the non-CB(1) vascular cannabinoid receptor on anandamide-induced changes in mean, systolic and diastolic blood pressure (MBP, SBP, DBP), mesenteric (MBF) and renal (RBF) blood flow and heart rate (HR) in urethane-anaesthetized rats was examined. KEY RESULTS: In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR. In pithed rats, anandamide (3 micromol.kg(-1)) decreased blood pressure by about 15-20% of the basal value without affecting HR, MBF and RBF. All vascular changes were reduced by about 30-70% by cannabidiol and O-1918 (3 micromol.kg(-1), each). CONCLUSIONS AND IMPLICATIONS: Non-CB(1) cannabinoid vascular receptors, sensitive to O-1918, contribute to the hypotensive effect of anandamide in anaesthetized rats. Activation of these receptors may be therapeutically important as the endocannabinoid system could be activated as a compensatory mechanism in various forms of hypertension.
