ConvolvineCAS# 537-30-4 |
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| Cas No. | 537-30-4 | SDF | Download SDF |
| PubChem ID | 279064 | Appearance | White powder |
| Formula | C16H21NO4 | M.Wt | 291.34 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | N-Demethylconvolamine; O-Methyl N-demethylphyllalbine; Norconvolamine; Veratroylnortropine | ||
| Solubility | Soluble in chloroform and DMSO | ||
| Chemical Name | 8-azabicyclo[3.2.1]octan-3-yl 3,4-dimethoxybenzoate | ||
| SMILES | COC1=C(C=C(C=C1)C(=O)OC2CC3CCC(C2)N3)OC | ||
| Standard InChIKey | HDLNHIIKSUHARQ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H21NO4/c1-19-14-6-3-10(7-15(14)20-2)16(18)21-13-8-11-4-5-12(9-13)17-11/h3,6-7,11-13,17H,4-5,8-9H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Convolvine and its derivatives exhibit pronounced antihypoxic, immunomodulating, and anti-inflammatory activity. 2. Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS,convolvine has revealed characteristics of a sedative and nootropic agent. 3. Convolvine and its derivatives exhibit cytotoxic activity, the alkaloids N-benzylconvolvine and N-chloroacetylconvolvine at concentrations of 10 ug/mL exhibit the greatest activity against HeLa and Hep cancer cell cultures. |
| Targets | Immunology & Inflammation related |
Convolvine Dilution Calculator
Convolvine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4324 mL | 17.1621 mL | 34.3242 mL | 68.6483 mL | 85.8104 mL |
| 5 mM | 0.6865 mL | 3.4324 mL | 6.8648 mL | 13.7297 mL | 17.1621 mL |
| 10 mM | 0.3432 mL | 1.7162 mL | 3.4324 mL | 6.8648 mL | 8.581 mL |
| 50 mM | 0.0686 mL | 0.3432 mL | 0.6865 mL | 1.373 mL | 1.7162 mL |
| 100 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.6865 mL | 0.8581 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effect of tea making and boiling processes on the degradation of tropane alkaloids in tea and pasta samples contaminated with Solanaceae seeds and coca leaf.[Pubmed:30857698]
Food Chem. 2019 Jul 30;287:265-272.
In this study, the degradation of tropane alkaloids in pasta under boiling (100 degrees C during 10min) and tea making (100 degrees C and let cool 5min) conditions has been evaluated for the first time. Pasta and green tea were contaminated with Datura Stramonium and Brugmansia Arborea seeds (pasta and green tea), whereas coca leaf tea was directly analysed. The compounds were extracted using solid-liquid extraction coupled to a preconcentration stage (only for the cooking water), and the compounds were analysed by liquid chromatography coupled to mass spectrometry (Exactive-Orbitrap analyser). Degradation studies indicate that concentration of tropane alkaloids decreases, and it depends on the compound, observing the highest degradation for tropinone, tropane, cuscohygrine and tropine, as well as it was observed that compounds migrated to the aqueous phase during cooking step. Finally, post-targeted analysis was performed and other tropane alkaloids were found, as scopine, tigloidine or Convolvine, showing a similar behaviour under cooking conditions.
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