QX 314 chlorideNa+ channel blocker CAS# 5369-03-9 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 5369-03-9 | SDF | Download SDF |
| PubChem ID | 21462 | Appearance | Powder |
| Formula | C16H27N2OCl | M.Wt | 298.85 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic) | ||
| Chemical Name | [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;chloride | ||
| SMILES | CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-] | ||
| Standard InChIKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. |
QX 314 chloride Dilution Calculator
QX 314 chloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3462 mL | 16.7308 mL | 33.4616 mL | 66.9232 mL | 83.654 mL |
| 5 mM | 0.6692 mL | 3.3462 mL | 6.6923 mL | 13.3846 mL | 16.7308 mL |
| 10 mM | 0.3346 mL | 1.6731 mL | 3.3462 mL | 6.6923 mL | 8.3654 mL |
| 50 mM | 0.0669 mL | 0.3346 mL | 0.6692 mL | 1.3385 mL | 1.6731 mL |
| 100 mM | 0.0335 mL | 0.1673 mL | 0.3346 mL | 0.6692 mL | 0.8365 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons.[Pubmed:8205485]
Brain Res. 1994 Mar 14;639(2):320-4.
Opiates hyperpolarize locus coeruleus neurons by simultaneously opening K+ channels and turning off a resting Na(+)-dependent inward current. Intracellularly applied QX-314 reduced the opiate current to approximately 40% of the control and the residual current did not reverse near EK, suggesting lack of a significant K+ component. Replacement of Na+ virtually abolished the residual opiate response. Thus, QX-314 blocks the K+ but not the Na(+)-dependent component of the opiate-induced outward current in LC neurons.
The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.[Pubmed:4541340]
J Gen Physiol. 1973 Jul;62(1):37-57.
The inhibition of sodium currents by quaternary derivatives of lidocaine was studied in single myelinated nerve fibers. Membrane currents were diminished little by external quaternary lidocaine (QX). QX present in the axoplasm (<0.5 mM) inhibited sodium currents by more than 90%. Inhibition occurred as the sum of a constant, tonic phase and a variable, voltage-sensitive phase. The voltage-sensitive inhibition was favored by the application of membrane potential patterns which produce large depolarizations when sodium channels are open. Voltage-sensitive inhibition could be reversed by small depolarizations which opened sodium channels. One explanation of this observation is that QX molecules enter open sodium channels from the axoplasmic side and bind within the channels. The voltage dependence of the inhibition by QX suggests that the drug binds at a site which is about halfway down the electrical gradient from inside to outside of the sodium channel.
