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Cinobufotenine

CAS# 60657-23-0

Cinobufotenine

Catalog No. BCN9783----Order now to get a substantial discount!

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Cinobufotenine: 5mg $196 In Stock
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Chemical structure

Cinobufotenine

3D structure

Chemical Properties of Cinobufotenine

Cas No. 60657-23-0 SDF Download SDF
PubChem ID 656705 Appearance Powder
Formula C13H19N2O M.Wt 219.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethylazanium
SMILES C[N+](C)(C)CCC1=CNC2=C1C=C(C=C2)O
Standard InChIKey HIYGARYIJIZXGW-UHFFFAOYSA-O
Standard InChI InChI=1S/C13H18N2O/c1-15(2,3)7-6-10-9-14-13-5-4-11(16)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3/p+1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cinobufotenine

The glandular body of Bufo bufo gargarizans Cantor.

Biological Activity of Cinobufotenine

DescriptionCinobufotenine is a potent stimulant of parasympathetic ganglia and its effect are competitively antagonized by hexamethonium.

Cinobufotenine Dilution Calculator

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Cinobufotenine Molarity Calculator

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Preparing Stock Solutions of Cinobufotenine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.56 mL 22.7998 mL 45.5996 mL 91.1993 mL 113.9991 mL
5 mM 0.912 mL 4.56 mL 9.1199 mL 18.2399 mL 22.7998 mL
10 mM 0.456 mL 2.28 mL 4.56 mL 9.1199 mL 11.3999 mL
50 mM 0.0912 mL 0.456 mL 0.912 mL 1.824 mL 2.28 mL
100 mM 0.0456 mL 0.228 mL 0.456 mL 0.912 mL 1.14 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cinobufotenine

A comparison of cinobufotenine (the quaternary derivative of 5-HT) and some related compounds with coryneine (the quaternary derivative of dopamine) on the frog rectus, guinea-pig ileum and rat fundus strip preparations.[Pubmed:6449223]

Br J Pharmacol. 1980 Aug;69(4):597-600.

1 Coryneine is 2.7 times as active as Cinobufotenine on the frog rectus but on the guinea-pig ileum Cinobufotenine is 1.5 times as active as coryneine. Cinobufotenine is a potent stimulant of parasympathetic ganglia and its effect are competitively antagonized by hexamethonium. 2 The effects of pH on activity relative to a standard whose ionisation is constant (Me4+N or the trimethylammonium analogue of tryptamine) are consistent with the phenate form being weaker than the phenolic form but the changes are smaller than with coryneine because Cinobufotenine is a weaker acid. 3 The hydroxyl group makes a large contribution to activity. Cinobufotenine is 9 times as active as the analogue without a hydroxyl on the frog rectus and 12 times as active as it on the ileum. The 5-methoxy analogue is an antagonist on the frog rectus and a very weak partial agonist on the ileum. 4 Cinobufotenine and the quaternary derivative of tryptamine have less than one-thousandth of the activity of 5-hydroxytryptamine on the rat fundus strip.

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