(-)-Corlumine

CAS# 79082-64-7

(-)-Corlumine

Catalog No. BCN6632----Order now to get a substantial discount!

Product Name & Size Price Stock
(-)-Corlumine: 5mg $748 In Stock
(-)-Corlumine: 10mg Please Inquire In Stock
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(-)-Corlumine: 500mg Please Inquire Please Inquire
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Quality Control of (-)-Corlumine

Number of papers citing our products

Chemical structure

(-)-Corlumine

3D structure

Chemical Properties of (-)-Corlumine

Cas No. 79082-64-7 SDF Download SDF
PubChem ID 157478 Appearance Powder
Formula C21H21NO6 M.Wt 383.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6S)-6-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
SMILES CN1CCC2=CC(=C(C=C2C1C3C4=C(C5=C(C=C4)OCO5)C(=O)O3)OC)OC
Standard InChIKey SZDGAZFTAUFFQH-MOPGFXCFSA-N
Standard InChI InChI=1S/C21H21NO6/c1-22-7-6-11-8-15(24-2)16(25-3)9-13(11)18(22)19-12-4-5-14-20(27-10-26-14)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (-)-Corlumine

The herbs of Fumaria parviflora.

Biological Activity of (-)-Corlumine

Description1. Corlumine exhibits spasmolytic and GABA antagonist activity.
TargetsGABA Receptor

(-)-Corlumine Dilution Calculator

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(-)-Corlumine Molarity Calculator

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Preparing Stock Solutions of (-)-Corlumine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6082 mL 13.0412 mL 26.0824 mL 52.1648 mL 65.2061 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL 10.433 mL 13.0412 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL 5.2165 mL 6.5206 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.0433 mL 1.3041 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.6521 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (-)-Corlumine

Quantum chemical and experimental studies on the structure and vibrational spectra of an alkaloid--Corlumine.[Pubmed:24080578]

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:470-80.

The study concentrates on an important natural product, phthalide isoquinoline alkaloid Corlumine (COR) [(6R)-6-[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl] furo [3,4-e]-1,3-benzodioxol-8(6H)-one] well known to exhibit spasmolytic and GABA antagonist activity. It was fully characterized by a variety of experimental methods including vibrational spectroscopy (IR and Raman), thermal analysis (DSC), UV and SEM. For a better interpretation and analysis of the results quantum chemical calculations employing DFT were also performed. TD-DFT was employed to elucidate electronic properties for both gaseous and solvent environment using IEF-PCM model. Graphical representation of HOMO and LUMO would provide a valuable insight into the nature of reactivity and some of the structural and physical properties of the title molecule. The structure-activity relationship have been interpreted by mapping electrostatic potential surface (MEP), which is valuable information for the quality control of medicines and drug-receptor interactions. Stability of the molecule arising from hyper conjugative interactions, charge delocalisation has been analyzed using natural bond orbital (NBO) analysis. Computation of thermodynamical properties would help to have a deep insight into the molecule for further applications.

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