4'-O-MethylnyasolCAS# 79004-25-4 |
Quality Control & MSDS
3D structure
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| Cas No. | 79004-25-4 | SDF | Download SDF |
| PubChem ID | 23626544 | Appearance | Powder |
| Formula | C18H18O2 | M.Wt | 266.34 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(1Z,3R)-1-(4-methoxyphenyl)penta-1,4-dien-3-yl]phenol | ||
| SMILES | COC1=CC=C(C=C1)C=CC(C=C)C2=CC=C(C=C2)O | ||
| Standard InChIKey | MTYGOTBQCBXZQD-IJVDHGTGSA-N | ||
| Standard InChI | InChI=1S/C18H18O2/c1-3-15(16-8-10-17(19)11-9-16)7-4-14-5-12-18(20-2)13-6-14/h3-13,15,19H,1H2,2H3/b7-4-/t15-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. |
| Targets | Histamine Receptor |
4'-O-Methylnyasol Dilution Calculator
4'-O-Methylnyasol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7546 mL | 18.773 mL | 37.546 mL | 75.092 mL | 93.865 mL |
| 5 mM | 0.7509 mL | 3.7546 mL | 7.5092 mL | 15.0184 mL | 18.773 mL |
| 10 mM | 0.3755 mL | 1.8773 mL | 3.7546 mL | 7.5092 mL | 9.3865 mL |
| 50 mM | 0.0751 mL | 0.3755 mL | 0.7509 mL | 1.5018 mL | 1.8773 mL |
| 100 mM | 0.0375 mL | 0.1877 mL | 0.3755 mL | 0.7509 mL | 0.9386 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Preparative isolation and purification of four compounds from the Chinese medicinal herb rhizoma Anemarrhenae by high-speed counter-current chromatography.[Pubmed:16364341]
J Chromatogr A. 2006 Feb 3;1104(1-2):69-74.
High-speed counter-current chromatography (HSCCC) was applied to the separation and purification of mangiferin, neomangiferin, cis-hinkiresinol and (-)-4'-O-methylnyasol from the Chinese medicinal herb rhizoma Anemarrhenae. Five hundred milligrams of crude extracts were separated by using n-butanol-acetic acid (1%) (1:1, v/v) as the two-phase solvent system and yielded 35.3 mg of neomangiferin and 245.4 mg of mangiferin. During this separation, cis-hinkiresinol and (-)-4'-O-methylnyasol were still maintained in the stationary phase. The stationary phase was collected, evaporated to dryness and separated with light petroleum-ethyl acetate-methanol-water (1:1:1.2:0.8, v/v) and 1:1:1.4:0.6 (v/v) in gradient elution, which yielded 17.2 mg of cis-hinkiresinol and 12.4 mg of (-)-4'-O-methylnyasol. The purities of mangiferin, neomangiferin, cis-hinkiresinol and (-)-4'-O-methylnyasol were 96.3, 98.0, 97.3 and 98.2%, respectively, as determined by HPLC. The chemical structures of these components were identified by 1H NMR and 13C NMR.
Inhibitory effects of norlignans isolated from Anemarrhena asphodeloides on degranulation of rat basophilic leukemia- 2H3Cells.[Pubmed:27780134]
Biomed Pharmacother. 2016 Dec;84:1061-1066.
Anemarrhena asphodeloides is known to suppress inflammation and lower various fevers. To determine the active component of A. asphodeloides, ethanol (EtOH) extract of A. asphodeloides rhizomes was fractionized. The compounds isolated from the dichloromethane (CH2Cl2) soluble fraction were identified as 4'-O-methylnyasol (1), nyasol (2), 3''-methoxynyasol (3), 3''-hydroxy-4''-methoxy-4''-dehydroxynyasol (4), 4-hydroxybenzaldehyde (5), and 4-hydroxyacetophenone (6). The four norlignans (1-4) potently inhibited the release of beta-hexosaminidase from immunoglobulin E (IgE)/dinitrophenol-conjugated bovine serum albumin (DNP-BSA)-treated rat basophilic leukemia (RBL)-2H3 and A23187 plus phorbol 12-myristate 13-acetate co-treated isolated rat primary mast cells, as markers of degranulation and histamine release. The intraperitoneal treatment with the EtOH extract significantly suppressed the fetal reaction, and serum histamine release induced by compound 48/80 in mice. These results suggest that the four active norlignan compounds and the EtOH extract of A. asphodeloides may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
