Retinyl (Vitamin A) PalmitateCAS# 79-81-2 |
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Quality Control & MSDS
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| Cas No. | 79-81-2 | SDF | Download SDF |
| PubChem ID | 5280531 | Appearance | Powder |
| Formula | C36H60O2 | M.Wt | 524.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Retinyl Palmitate; VITAMIN A PALMITATE; Retinol Palmitate | ||
| Solubility | Ethanol : 10 mg/mL (19.05 mM; Need ultrasonic) DMSO : 5 mg/mL (9.53 mM; Need ultrasonic) | ||
| Chemical Name | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate | ||
| SMILES | CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C | ||
| Standard InChIKey | VYGQUTWHTHXGQB-FFHKNEKCSA-N | ||
| Standard InChI | InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Retinyl (Vitamin A) Palmitate Dilution Calculator
Retinyl (Vitamin A) Palmitate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9053 mL | 9.5263 mL | 19.0527 mL | 38.1054 mL | 47.6317 mL |
| 5 mM | 0.3811 mL | 1.9053 mL | 3.8105 mL | 7.6211 mL | 9.5263 mL |
| 10 mM | 0.1905 mL | 0.9526 mL | 1.9053 mL | 3.8105 mL | 4.7632 mL |
| 50 mM | 0.0381 mL | 0.1905 mL | 0.3811 mL | 0.7621 mL | 0.9526 mL |
| 100 mM | 0.0191 mL | 0.0953 mL | 0.1905 mL | 0.3811 mL | 0.4763 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Vitamin A palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.
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Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice.[Pubmed:24657715]
Vaccine. 2014 May 7;32(22):2521-4.
Vitamin A deficiency (VAD) is a leading cause of pediatric morbidity and mortality due to infectious diseases. Recent pre-clinical studies have revealed that VAD impairs mucosal IgA-producing antibody forming cell (AFC) responses toward a paramyxovirus vaccine in the upper respiratory tract (URT), thus impeding a first line of defense at the pathogen's point-of-entry. The studies described here tested the hypothesis that VAD may also impair immune responses after FluMist vaccinations. Results show that (i) IgA-producing antibody forming cells (AFCs) are significantly reduced following FluMist vaccination in VAD mice, and (ii) oral doses of either retinyl palmitate or retinoic acid administered on days 0, 3, and 7 relative to vaccination rescue the response. Data encourage the conduct of clinical studies to determine if there are FluMist vaccine weaknesses in human VAD populations and to test corrective supplementation strategies. Improvements in vaccine efficacy may ultimately reduce the morbidity and mortality caused by influenza virus worldwide.
Effect of supplemental beta-carotene compared to retinyl palmitate on fatty acid profile and expression of mRNA from genes involved in vitamin A metabolism in beef feedlot cattle.[Pubmed:28370816]
Anim Sci J. 2017 Sep;88(9):1380-1387.
To examine the effects of dietary beta-carotene (betaC) or retinyl palmitate (RP) on fatty acid (FA) profile and mRNA expression, samples were collected from 24 Angus-cross calves that were allotted to four treatments consisting of RP supplemented at 2200 IU/kg, and synthetic beta-carotene (SbetaC) supplemented at one, five or 10 times RP. Longissimus muscle (LM) cis-9, trans-11 conjugated linoleic acid was greater in RP compared to SbetaC1X (P = 0.04). The polyunsaturated:saturated FA increased linearly (P = 0.04) in the LM as dietary SbetaC increased. Expression of betaC oxygenase 2 (betaCO2), an enzyme that cleaves beta-carotene, was greater in the LM for SbetaC1X compared to RP and decreased linearly as SbetaC increased (P
Vitamin A is rapidly degraded in retinyl palmitate-fortified soybean oil stored under household conditions.[Pubmed:25003735]
J Agric Food Chem. 2014 Jul 30;62(30):7559-66.
Oil fortification with retinyl palmitate is intended to lower the prevalence of vitamin A deficiency in populations at risk. Although the stability of vitamin A in vegetable oil has been shown to depend on environmental factors, very little information is known about the stability of vitamin A in preoxidized vegetable oils. The present study investigated the stability of retinyl palmitate in mildly oxidized (peroxide value < 2 mequiv O2/kg) and highly oxidized (peroxide value > 10 mequiv O2/kg) soybean oil stored under domestic and retail conditions. Soybean oil was filled in transparent bottles, which were exposed to cold fluorescent light at 22 or 32 degrees C for 56 days. Periodic oil sampling increased the headspace, thereby mimicking consumer handling. Loss of retinyl palmitate in soybean oil by a maximum of 84.8 +/- 5.76% was accompanied by a decrease of vitamin E by 53.3 +/- 0.87% and by an increase of the peroxide value from 1.20 +/- 0.004 to 24.3 +/- 0.02 mequiv O2/kg. Fortification of highly oxidized oil with 31.6 IU/g retinyl palmitate led to a doubling of the average decrease of retinol per day compared to fortification of mildly oxidized oil. In conclusion, oil fortification programs need to consider the oxidative status of the oil used for retinyl palmitate fortification.
