Depressine

CAS# 176182-06-2

Depressine

2D Structure

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Quality Control of Depressine

3D structure

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Depressine

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Chemical Properties of Depressine

Cas No. 176182-06-2 SDF Download SDF
PubChem ID 101696497 Appearance Powder
Formula C30H40O18 M.Wt 688.63
Type of Compound Iridoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (2S,3R,4S)-3-ethenyl-4-[2-[2-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzoyl]oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
SMILES COC(=O)C1=COC(C(C1CCOC(=O)C2=C(C(=CC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)C=C)OC4C(C(C(C(O4)CO)O)O)O
Standard InChIKey ODVCSBYBNISFOU-HNEGCACGSA-N
Standard InChI InChI=1S/C30H40O18/c1-3-12-13(15(26(40)42-2)11-44-28(12)48-30-25(39)23(37)21(35)18(10-32)47-30)7-8-43-27(41)14-5-4-6-16(19(14)33)45-29-24(38)22(36)20(34)17(9-31)46-29/h3-6,11-13,17-18,20-25,28-39H,1,7-10H2,2H3/t12-,13+,17-,18-,20-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Depressine

The aerial parts of Gentiana depressa.

Biological Activity of Depressine

DescriptionDepressine is a natural product from Gentiana depressa.

Protocol of Depressine

Structure Identification
Phytochemistry, 1996, 42(1):139-143.

Iridoids and flavones from Gentiana depressa.[Reference: WebLink]

The dried aerial parts of Gentiana depressa were found to contain the known flavones, isoscoparin, 2″-glucosyl isovitexin and 2″-glucosyl isoorientin, the known iridoid loganin, and two new iridoid glucosides; 3″-glucosyl depresteroside and Depressine. The last two compounds were characterized at 7-[7-(3-β-glucopyranosyloxy-2-hydroxy-benzoyl)-loganoyl] secologanol and 7-(3-β-glucopyranosyloxy-2-hydroxy-benzoyl) secologanol, respectively, by spectroscopy and chemical transformations.

Depressine Dilution Calculator

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Depressine Molarity Calculator

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Preparing Stock Solutions of Depressine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4522 mL 7.2608 mL 14.5216 mL 29.0432 mL 36.304 mL
5 mM 0.2904 mL 1.4522 mL 2.9043 mL 5.8086 mL 7.2608 mL
10 mM 0.1452 mL 0.7261 mL 1.4522 mL 2.9043 mL 3.6304 mL
50 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
100 mM 0.0145 mL 0.0726 mL 0.1452 mL 0.2904 mL 0.363 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Depressine

The depressine Syndrome: a follow-up study of 130 professionals working overseas.[Pubmed:1124808]

Am J Psychiatry. 1975 Jun;132(6):636-40.

A four-year follow-up of professional personnel who had been working overseas indicates that the depressive syndrome was the most common diagnosable psychiatric illness in this population. The study also shows that in this content the syndrome had a good prognosis. It therefore seems reasonable not to exclude persons with diagnosable depression from assignment abroad but, rather, to identify the syndrome and recommend necessary treatment.

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