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Diosmetin-7-O-beta-D-glucopyranoside

CAS# 20126-59-4

Diosmetin-7-O-beta-D-glucopyranoside

Catalog No. BCN5328----Order now to get a substantial discount!

Product Name & Size Price Stock
Diosmetin-7-O-beta-D-glucopyranoside: 5mg $127 In Stock
Diosmetin-7-O-beta-D-glucopyranoside: 10mg Please Inquire In Stock
Diosmetin-7-O-beta-D-glucopyranoside: 20mg Please Inquire Please Inquire
Diosmetin-7-O-beta-D-glucopyranoside: 50mg Please Inquire Please Inquire
Diosmetin-7-O-beta-D-glucopyranoside: 100mg Please Inquire Please Inquire
Diosmetin-7-O-beta-D-glucopyranoside: 200mg Please Inquire Please Inquire
Diosmetin-7-O-beta-D-glucopyranoside: 500mg Please Inquire Please Inquire
Diosmetin-7-O-beta-D-glucopyranoside: 1000mg Please Inquire Please Inquire

Quality Control of Diosmetin-7-O-beta-D-glucopyranoside

Number of papers citing our products

Chemical structure

Diosmetin-7-O-beta-D-glucopyranoside

3D structure

Chemical Properties of Diosmetin-7-O-beta-D-glucopyranoside

Cas No. 20126-59-4 SDF Download SDF
PubChem ID 11016019 Appearance Yellow powder
Formula C22H22O11 M.Wt 462.41
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O
Standard InChIKey WKUHPOMCLBLCOV-MIUGBVLSSA-N
Standard InChI InChI=1S/C22H22O11/c1-30-14-3-2-9(4-11(14)24)15-7-13(26)18-12(25)5-10(6-16(18)32-15)31-22-21(29)20(28)19(27)17(8-23)33-22/h2-7,17,19-25,27-29H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Diosmetin-7-O-beta-D-glucopyranoside

The flower of Chrysanthemum morifolium

Biological Activity of Diosmetin-7-O-beta-D-glucopyranoside

DescriptionDiosmetin-7-O-beta-D-glucopyranoside has antioxidant activity.
In vitro

An HPLC-DPPH method for antioxidant activity from sugarcane molasses.[Reference: WebLink]

Zuckerindustrie., 2015, 140(10):632-9.

Sugarcane molasses is potentially rich in health-promoting phenolic compounds. Present study was designed to optimize experimental conditions for ultrasonic-assisted extraction of antioxidant compounds from sugarcane molasses using response surface methodology.
METHODS AND RESULTS:
An HPLCDPPH method for simultaneous determination of antioxidant activity was also developed. Ethanol concentration 80-84% (v/v), temperature 58-59 degrees C, and 47-50 min time duration were the most favorable conditions. In these conditions, the optimal experimental results were total phenolic content 18 mg gallic acid equivalents/g, with DPPH free radical scavenging ability of 92%, which was same as the predicted values by RSM model. Catechin, vanillic acid, isorhamnetin-3-O-glucoside, eugenol, schaftoside, Diosmetin-7-O-beta-D-glucopyranoside, ferulic acid, and caffeoylquinic acid were identified using HPLC-MS/MS. Among the antioxidant compounds, schaftoside was the most abundant antioxidant (92.081 mu g/g dry substance), while ferulic acid exhibited the highest antioxidant activity.
CONCLUSIONS:
These results suggest that HPLC-DPPH method is more specific, accurate and less time consuming and can sever as a quality control tool.

Protocol of Diosmetin-7-O-beta-D-glucopyranoside

Structure Identification
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:150-7.

An efficient preparative procedure for main flavonoids from the peel of Trichosanthes kirilowii Maxim. using polyamide resin followed by semi-preparative high performance liquid chromatography.[Pubmed: 25023212]

In this study, a simple and efficient preparative procedure was developed for preparation of seven flavonoids from the peel of Trichosanthes kirilowii Maxim. using polyamide resin followed by semi-preparative high performance liquid chromatography (SPHPLC).
METHODS AND RESULTS:
First, the ethyl acetate fraction from the peel of T. kirilowii Maxim. obtained "prefractionation" using polyamide resin, which yielded two subfractions. And then the two subfractions were isolated by SPHPLC with an isocratic elution of methanol-water. Finally, seven known flavonoids were purified from 35 g of ethyl acetate extract including quercetin-3-O-[α-l-rhamnose (1→2)-β-d-glucopyranosyl]-5-O-β-d-glucopyranoside (19 mg), quercetin-3-O-rutinoside (24 mg), apigenin-7-O-β-d-glucopyranoside (10mg), diosmetin-7-O-β-d-glucopyranoside (Diosmetin-7-O-beta-D-glucopyranoside,45 mg), luteolin (21 mg), apigenin (15 mg), and diosmetin (56 mg). The purities of the compounds were determined by HPLC and the chemical structures were confirmed by UV and NMR analysis.
CONCLUSIONS:
In the present study, a simple, effective, and rapid procedure was established for preparative separation of multiple components from the peel of T. kirilowii Maxim. Furthermore, it was scalable and economical, so it was a promising basis for large-scale preparation of flavonoids from other plant extracts.

Diosmetin-7-O-beta-D-glucopyranoside Dilution Calculator

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Diosmetin-7-O-beta-D-glucopyranoside Molarity Calculator

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Preparing Stock Solutions of Diosmetin-7-O-beta-D-glucopyranoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1626 mL 10.8129 mL 21.6258 mL 43.2517 mL 54.0646 mL
5 mM 0.4325 mL 2.1626 mL 4.3252 mL 8.6503 mL 10.8129 mL
10 mM 0.2163 mL 1.0813 mL 2.1626 mL 4.3252 mL 5.4065 mL
50 mM 0.0433 mL 0.2163 mL 0.4325 mL 0.865 mL 1.0813 mL
100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4325 mL 0.5406 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Diosmetin-7-O-beta-D-glucopyranoside

Identification and determination of major constituents in a traditional Chinese medicine compound recipe Xiongdankaiming tablet using HPLC-PDA/ESI-MS(n) and HPLC-UV/ELSD.[Pubmed:23825146]

J Zhejiang Univ Sci B. 2013 Jul;14(7):604-14.

Xiongdankaiming tablet (XDKMT), a well-known compound in traditional Chinese medicine, is widely used for the treatment of acute iridocyclitis and primary open-angle glaucoma. In this paper, accurate and reliable methods were developed for the identification of 20 constituents using high-performance liquid chromatography with photo-diode array and electron spray ionization-mass spectrometry (HPLC-PDA/ESI-MS(n)), and determination of nine of the constituents (chlorogenic acid, gentiopicroside, isochlorogenic acid B, Diosmetin-7-O-beta-D-glucopyranoside, apigenin, diosmetin, tauroursodeoxycholic acid, acacetin, and taurochenodeoxycholic acid) was developed using HPLC with ultraviolet absorption detector and evaporative light scattering detector (HPLC-UV/ELSD) for the first time. The best results were obtained on a Zorbax SB-C18 column with gradient elution using water (0.1% formic acid) (A) and methanol (0.1% formic acid) (B) at a fl ow rate of 0.7 ml/min. Tauroursodeoxycholic acid and taurochenodeoxycholic acid, owing to their low UV absorption, were detected by ELSD. The other seven compounds were analyzed by HPLC-UV with variable wavelengths. The calibration curves of all nine constituents showed good linear regression (R(2)>0.9996) within the linearity ranges. The limits of detection and quantification were in the ranges of 0.0460-9.90 mug/ml and 0.115-24.8 mug/ml, respectively. The accuracy, in terms of recovery, varied from 95.3% to 104.9% with relative standard deviations (RSDs) less than 4.4%. Precision (with the intra- and inter-day variations less than 4.4%) was also suitable for its intended use. The developed method was successfully applied for the analysis of major components in XDKMT, which provides an appropriate method for the quality control of XDKMT.

An efficient preparative procedure for main flavonoids from the peel of Trichosanthes kirilowii Maxim. using polyamide resin followed by semi-preparative high performance liquid chromatography.[Pubmed:25023212]

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:150-7.

In this study, a simple and efficient preparative procedure was developed for preparation of seven flavonoids from the peel of Trichosanthes kirilowii Maxim. using polyamide resin followed by semi-preparative high performance liquid chromatography (SPHPLC). First, the ethyl acetate fraction from the peel of T. kirilowii Maxim. obtained "prefractionation" using polyamide resin, which yielded two subfractions. And then the two subfractions were isolated by SPHPLC with an isocratic elution of methanol-water. Finally, seven known flavonoids were purified from 35 g of ethyl acetate extract including quercetin-3-O-[alpha-l-rhamnose (1-->2)-beta-d-glucopyranosyl]-5-O-beta-d-glucopyranoside (19 mg), quercetin-3-O-rutinoside (24 mg), apigenin-7-O-beta-d-glucopyranoside (10mg), Diosmetin-7-O-beta-D-glucopyranoside (45 mg), luteolin (21 mg), apigenin (15 mg), and diosmetin (56 mg). The purities of the compounds were determined by HPLC and the chemical structures were confirmed by UV and NMR analysis. In the present study, a simple, effective, and rapid procedure was established for preparative separation of multiple components from the peel of T. kirilowii Maxim. Furthermore, it was scalable and economical, so it was a promising basis for large-scale preparation of flavonoids from other plant extracts.

[Chemical constituents of Trichosanthes kirilowii peels].[Pubmed:25174107]

Zhong Yao Cai. 2014 Mar;37(3):428-31.

OBJECTIVE: To study the chemical constituents of the peels of Trichosanthes kirilowii. METHODS: Many chromatographic techniques were used including repeated silica column chromatography, polyamide resin and semi-preparative high performance liquid chromatography. According to the physical and chemical properties and spectral analysis, the chemical structures of the compounds were determined. RESULTS: Thirteen compounds were isolated and identified as quercetin-3-O-[alpha-L-rhamnose(1 --> 2)-beta-D-glucopyranosyl]-5-O-beta-D-glucopyranoside (1), quercetin-3-O-rutinoside (2), apigenin-7-O-beta-D-glucopyranoside (3), Diosmetin-7-O-beta-D-glucopyranoside (4), luteolin (5), apigenin (6), diosmetin (7), methyl palmitate (8), methyl stearate (9), palmitic acid (10), beta-sitosterol (11), alpha-spin-asterol (12) and stigmasterol (13). CONCLUSION: Compounds 1 - 3, 5 - 7 are isolated from this plant for the first time.

Description

Diosmetin-7-O-β-D-glucopyranoside is a natural product isolated from the flowers of Chrysanthemum morifolium, with antioxidant activity.

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