Episappanol

CAS# 111254-18-3

Episappanol

Catalog No. BCN7940----Order now to get a substantial discount!

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Chemical structure

Episappanol

3D structure

Chemical Properties of Episappanol

Cas No. 111254-18-3 SDF Download SDF
PubChem ID 13846650 Appearance Powder
Formula C16H16O6 M.Wt 304.29
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,4R)-3-[(3,4-dihydroxyphenyl)methyl]-2,4-dihydrochromene-3,4,7-triol
SMILES C1C(C(C2=C(O1)C=C(C=C2)O)O)(CC3=CC(=C(C=C3)O)O)O
Standard InChIKey MPGFEHZDABUJFR-HZPDHXFCSA-N
Standard InChI InChI=1S/C16H16O6/c17-10-2-3-11-14(6-10)22-8-16(21,15(11)20)7-9-1-4-12(18)13(19)5-9/h1-6,15,17-21H,7-8H2/t15-,16-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Episappanol

The heartwood of Caesalpinia sappan Linn

Biological Activity of Episappanol

Description1. Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).
TargetsTNF-α | IL Receptor

Episappanol Dilution Calculator

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Episappanol Molarity Calculator

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Preparing Stock Solutions of Episappanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2863 mL 16.4317 mL 32.8634 mL 65.7268 mL 82.1585 mL
5 mM 0.6573 mL 3.2863 mL 6.5727 mL 13.1454 mL 16.4317 mL
10 mM 0.3286 mL 1.6432 mL 3.2863 mL 6.5727 mL 8.2158 mL
50 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.3145 mL 1.6432 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6573 mL 0.8216 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Episappanol

Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.[Pubmed:26951869]

Food Funct. 2016 Mar;7(3):1671-9.

The heartwood of Caesalpinia sappan is a traditional ingredient of food and beverages in South East Asia and has been used in traditional medicine as an analgesic and anti-inflammatory drug or to promote blood circulation. Scientific studies have confirmed different bioactivities associated with its use. Here, five fractions were isolated from the ethanolic extract of C. sappan heartwood, including Episappanol (1), protosappanin C (2), brazilin (3), (iso-)protosappanin B (4) and sappanol (5) using high-performance liquid chromatography (HPLC). All compounds were tested for their anti-inflammatory effects in two different cell lines. Cytokine concentrations in the cell supernatant were determined using enzyme-linked immunosorbent assay (ELISA), and mRNA levels were measured using reverse-transcription quantitative polymerase chain reaction (RT-qPCR). In lipopolysaccharide-stimulated macrophages, all compounds significantly inhibited the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Sappanol (5) increased the secretion of the anti-inflammatory IL-10. In IL-1beta-stimulated chondrocytes, all fractions reduced the mRNA expression and the secretion of the pro-inflammatory cytokines IL-6 and TNF-alpha. The highest anti-inflammatory effect was found for brazilin (3) in both cell lines. Of note, this is the first study which shows the anti-inflammatory effect of sappanol and Episappanol. This study provides evidence for the efficacy of the traditional use of C. sappan as an anti-inflammatory remedy. Given the high prevalence of inflammation-related pathologies including arthritis, and the urgent need to clinically intervene with these diseases, the anti-inflammatory activity of diverse compounds from C. sappan may be of interest for the development of complementary and alternative treatment strategies.

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