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Ginkgolic acid C17:1

CAS# 111047-30-4

Ginkgolic acid C17:1

2D Structure

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Ginkgolic acid C17:1: 5mg $86 In Stock
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Quality Control of Ginkgolic acid C17:1

3D structure

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Ginkgolic acid C17:1

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Chemical Properties of Ginkgolic acid C17:1

Cas No. 111047-30-4 SDF Download SDF
PubChem ID 5469634 Appearance White-yellowish powder or waxy
Formula C24H38O3 M.Wt 374.56
Type of Compound Phenols Storage Desiccate at -20°C
Synonyms Ginkgolic acid II; 6-(10Z)-Heptadecenylsalicylic acid
Solubility Soluble in diethyl ether, ethanol, n-hexane, methanol and petroleum ether; sparingly soluble in acetone; practically insoluble in water
Chemical Name 2-[(Z)-heptadec-10-enyl]-6-hydroxybenzoic acid
SMILES CCCCCCC=CCCCCCCCCCC1=C(C(=CC=C1)O)C(=O)O
Standard InChIKey MBYNDKVOZOAOIS-FPLPWBNLSA-N
Standard InChI InChI=1S/C24H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h7-8,17,19-20,25H,2-6,9-16,18H2,1H3,(H,26,27)/b8-7-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ginkgolic acid C17:1

The leaves of Ginkgo biloba L.

Biological Activity of Ginkgolic acid C17:1

DescriptionGinkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
TargetsAntifection
In vitro

Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation[Reference: WebLink]

International Journal of Food Microbiology Volume 174, 17 March 2014, Pages 47–55

Infection by enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a worldwide problem, and there is no effective therapy. Biofilm formation is closely related to EHEC infection and is also a mechanism of antimicrobial resistance.
METHODS AND RESULTS:
Antibiofilm screening of 560 purified phytochemicals against EHEC showed that ginkgolic acid C15:1 and Ginkgolic acid C17:1 at 5 μg/ml and Ginkgo biloba extract at 100 μg/ml significantly inhibited EHEC biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. Importantly, at their working concentrations, ginkgolic acids and G. biloba extract did not affect bacterial growth. Transcriptional analyses showed that ginkgolic acid C15:1 repressed curli genes and prophage genes in EHEC, and these findings were in-line with reduced fimbriae production and biofilm reductions. Interestingly, ginkgolic acids and G. biloba extract did not inhibit the biofilm formation of a commensal E. coli K-12 strain. In addition, ginkgolic acids and G. biloba extract inhibited the biofilm formation of three Staphylococcus aureus strains.
CONCLUSIONS:
The findings of this study suggest that plant secondary metabolites represent an important resource for biofilm inhibitors.

Ginkgolic acid C17:1 Dilution Calculator

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Preparing Stock Solutions of Ginkgolic acid C17:1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6698 mL 13.349 mL 26.698 mL 53.396 mL 66.745 mL
5 mM 0.534 mL 2.6698 mL 5.3396 mL 10.6792 mL 13.349 mL
10 mM 0.267 mL 1.3349 mL 2.6698 mL 5.3396 mL 6.6745 mL
50 mM 0.0534 mL 0.267 mL 0.534 mL 1.0679 mL 1.3349 mL
100 mM 0.0267 mL 0.1335 mL 0.267 mL 0.534 mL 0.6674 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects.

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