Vitamin A2CAS# 11103-57-4 |
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| Cas No. | 11103-57-4 | SDF | Download SDF |
| PubChem ID | 6436043 | Appearance | Powder |
| Formula | C20H28O | M.Wt | 284.44 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 3-Dehydro Retinol;Dehydroretinol;3,4-didehydroretinol;all-trans-3,4-Didehydroretinol | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)nona-2,4,6,8-tetraen-1-ol | ||
| SMILES | CC1=C(C(CC=C1)(C)C)C=CC(=CC=CC(=CCO)C)C | ||
| Standard InChIKey | XWCYDHJOKKGVHC-OVSJKPMPSA-N | ||
| Standard InChI | InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6-13,21H,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Vitamin A2 Dilution Calculator
Vitamin A2 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5157 mL | 17.5784 mL | 35.1568 mL | 70.3136 mL | 87.892 mL |
| 5 mM | 0.7031 mL | 3.5157 mL | 7.0314 mL | 14.0627 mL | 17.5784 mL |
| 10 mM | 0.3516 mL | 1.7578 mL | 3.5157 mL | 7.0314 mL | 8.7892 mL |
| 50 mM | 0.0703 mL | 0.3516 mL | 0.7031 mL | 1.4063 mL | 1.7578 mL |
| 100 mM | 0.0352 mL | 0.1758 mL | 0.3516 mL | 0.7031 mL | 0.8789 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.[Pubmed:27059013]
FEBS Lett. 2016 May;590(9):1304-12.
In humans, a considerable fraction of the retinoid pool in skin is derived from Vitamin A2 (all-trans 3,4-dehydroretinal). Vitamin A2 may be locally generated by keratinocytes, which can convert vitamin A1 (all-trans retinol) into Vitamin A2 in cell culture. We report that human cytochrome P450 (hP450) 27C1, a previously 'orphan' enzyme, can catalyze this reaction. Purified recombinant hP450 27C1 bound and desaturated all-trans retinol, retinal, and retinoic acid, as well as 11-cis-retinal. Although the physiological role of 3,4-dehydroretinoids in humans is unclear, we have identified hP450 27C1 as an enzyme capable of efficiently mediating their formation.
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