EuparinCAS# 532-48-9 |
Quality Control & MSDS
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Number of papers citing our products
| Cas No. | 532-48-9 | SDF | Download SDF |
| PubChem ID | 119039 | Appearance | Powder |
| Formula | C13H12O3 | M.Wt | 216.23 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone | ||
| SMILES | CC(=C)C1=CC2=CC(=C(C=C2O1)O)C(=O)C | ||
| Standard InChIKey | OPUFDNZTKHPZHM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H12O3/c1-7(2)12-5-9-4-10(8(3)14)11(15)6-13(9)16-12/h4-6,15H,1H2,2-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to cells up to the first twenty minutes after infection. 2. Euparin exhibits a moderate antioxidant activity. 3. Euparin exhibits antifungal activity against Trichophyton mentagrophytes. |
| Targets | Antifection |
Euparin Dilution Calculator
Euparin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.6247 mL | 23.1235 mL | 46.2471 mL | 92.4941 mL | 115.6176 mL |
| 5 mM | 0.9249 mL | 4.6247 mL | 9.2494 mL | 18.4988 mL | 23.1235 mL |
| 10 mM | 0.4625 mL | 2.3124 mL | 4.6247 mL | 9.2494 mL | 11.5618 mL |
| 50 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 1.8499 mL | 2.3124 mL |
| 100 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 0.9249 mL | 1.1562 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis.[Pubmed:8882437]
J Nat Prod. 1996 Mar;59(3):323-6.
Investigation on the roots of Helianthella quinquenervis (Hook.) A. Gray (Asteraceae), led to the isolation of one new benzofuran (6-methoxy-tremetone (1)) and a new prenylacetophenone (4-beta-D-(glucopyranosyloxy)-3-[3-methoxy-trans-isopenten-1 -yl] acetophenone (3)). In addition, 6-hydroxy-3-methoxytremetone (2), encecalin (6), Euparin (5), demethylencecalin (4), and angelic acid were obtained. Structural assignments of the isolated compounds were based on spectroscopic and spectrometric analysis. Natural products 1-4 showed marginal cytotoxicity against three human tumor cell lines [MCF-7, A-549, and HT-29]. Compounds 4 and 6 inhibited the radicle growth of Amaranthus hypochondriacus and Echinochloa crusgalli. Furthermore, substances 4-6 exhibited antifungal activity against Trichophyton mentagrophytes.
In vitro evaluation of cytotoxic activity of the ethanol extract and isolated compounds from the corms of Liatris spicata (L.) willd on HepG2.[Pubmed:27712097]
Nat Prod Res. 2017 Jun;31(11):1325-1328.
Investigation of the ethanol extract of the corms of Liatris spicata (L.) willd led to the isolation of two sterols: stigmasterol and its 3-O-glucoside, a triterpene: obtusifoliyl acetate, two benzofurans: Euparin and 6-hydroxy-3-methoxytremetone, three phenolic acids: protocatechuic, vanillic and ferulic acid and a sesquiterpene lactone igalan. The structures of the isolated compounds were established on the basis of physicochemical properties and spectral analysis (IR, EI/MS, (1)H NMR and (13)C NMR). The ethanol extract and its isolated compounds evidenced cytotoxic activities against human liver cancer cell line (HepG2), where igalan showed the highest potency (3.83 +/- 0.043) mug/mL, its effect was comparable to that of the standard drug doxorubicin(R) (3.73 +/- 0.036) mug/mL.
Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound.[Pubmed:23956770]
Evid Based Complement Alternat Med. 2013;2013:402364.
The antiviral activity of the organic extract (OE) of Eupatorium buniifolium against poliovirus type 1 was determined by in vitro assays with an effective concentration 50 (EC50) of 23.3 +/- 3.3 microg/mL. Bioassay-guided fractionation of the OE allowed the isolation of an active principle that was identified by spectroscopic methods ((1)H- and (13)C-NMR, EI-MS, UV, and IR spectroscopy) as the benzofuran Euparin. The plaque reduction assay in Vero cells was used to assess the antiviral activity of Euparin against poliovirus types 1, 2, and 3 with EC50 values of 0.47, 0.12, and 0.15 microg/mL, respectively. Moreover, this compound showed high selectivity indexes of 284.9, 1068, and 854.7, respectively. In order to identify the mechanism by which Euparin exerts its antiviral activity, the virucidal effect, the pretreatment of Vero cells, and the time of action on one viral replication cycle were evaluated. Results obtained demonstrated that Euparin exerts its effect during the early events of the replication cycle, from the virus adsorption to cells up to the first twenty minutes after infection. This is the first report on the presence of Euparin in E. buniifolium and its antiviral activity.
