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2''-O-Galloylhyperin

CAS# 53209-27-1

2''-O-Galloylhyperin

2D Structure

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3D structure

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2''-O-Galloylhyperin

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Chemical Properties of 2''-O-Galloylhyperin

Cas No. 53209-27-1 SDF Download SDF
PubChem ID 6453359 Appearance Yellow powder
Formula C28H24O16 M.Wt 616.48
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Hyperoside 2''-gallate; 3,3',4',5,7-Pentahydroxyflavone 3-β-galactoside 2''-gallate; Quercetin 3-β-galactoside 2''-gallate
Solubility DMSO : 100 mg/mL (162.21 mM; Need ultrasonic)
Chemical Name [(2S,3R,4S,5R,6R)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] 3,4,5-trihydroxybenzoate
SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)O)O
Standard InChIKey PXGWEUQZDRUMRE-UNZYZCBSSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2''-O-Galloylhyperin

1 Geranium sp. 2 Platycarya sp. 3 Pyrola sp.

Biological Activity of 2''-O-Galloylhyperin

Description2''-O-Galloylhyperin has effects on arrhythmias in an isolated tissue model of hypoxia and reperfusion.
In vitro

Effects of 2''-O-Galloylhyperin on arrhythmias in an isolated tissue model of hypoxia and reperfusion[Reference: WebLink]

Chin. Pharm. Bull., 2002, 18(3).

Effects of 2''-O-Galloylhyperin on arrhythmias in an isolated tissue model of hypoxia and reperfusion

Protocol of 2''-O-Galloylhyperin

Structure Identification
Chem Biodivers. 2007 Dec;4(12):2932-7.

Tetralones and flavonoids from Pyrola calliantha.[Pubmed: 18081103]


METHODS AND RESULTS:
Two new tetralones, pyrolones A (1) and B (2), and a new flavonol glycoside, 2''-O-(4-hydroxybenzoyl)hyperin (3), were isolated from Pyrola calliantha (whole plant), together with six structurally related compounds, including 2''-O-Galloylhyperin (4), hyperin (5), formononetin (6), quercetin 3-O-alpha-L-arabinopyranoside (7), quercetin 3-O-alpha-L-arabinofuranoside (8), and kaempferol 3-O-beta-D-galactopyranoside (9).
CONCLUSIONS:
The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic (UV, ORD, CD, NMR) and mass-spectrometric (HR-ESI-MS) analyses.

2''-O-Galloylhyperin Dilution Calculator

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Preparing Stock Solutions of 2''-O-Galloylhyperin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6221 mL 8.1106 mL 16.2211 mL 32.4423 mL 40.5528 mL
5 mM 0.3244 mL 1.6221 mL 3.2442 mL 6.4885 mL 8.1106 mL
10 mM 0.1622 mL 0.8111 mL 1.6221 mL 3.2442 mL 4.0553 mL
50 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.6488 mL 0.8111 mL
100 mM 0.0162 mL 0.0811 mL 0.1622 mL 0.3244 mL 0.4055 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2''-O-Galloylhyperin

Validated LC-MS/MS method for the simultaneous determination of hyperoside and 2''-O-galloylhyperin in rat plasma: application to a pharmacokinetic study in rats.[Pubmed:24375731]

Biomed Chromatogr. 2014 Aug;28(8):1057-63.

An LC-MS/MS method was developed for the first time to simultaneously determine hyperoside and 2''-O-galloylhyperin, two major components in Pyrola calliantha extract, in rat plasma. Following extraction by one-step protein precipitation with methanol, the analytes were separated on a Venusil MP-C18 column within 2 min, using methanol-water-formic acid (50:50:0.1, v/v/v) as the mobile phase at a flow rate of 0.4 mL/min. Detection was performed on electrospray negative ionization mass spectrometry by multiple-reaction monitoring of the transitions of 2''-O-galloylhyperin at m/z 615.1 --> 301.0, of hyperoside at m/z 463.1 --> 300.1, and of internal standard at m/z 415.1 --> 295.1. The limits of quantification were 2 ng/mL for both hyperoside and 2''-O-galloylhyperin. The precisions were <13.1%, and the accuracies were between -9.1 and 5.5% for both compounds. The method was successfully applied in pharmacokinetic studies following intravenous administration of the total flavonoids of P. calliantha extract in rats.

Tetralones and flavonoids from Pyrola calliantha.[Pubmed:18081103]

Chem Biodivers. 2007 Dec;4(12):2932-7.

Two new tetralones, pyrolones A (1) and B (2), and a new flavonol glycoside, 2''-O-(4-hydroxybenzoyl)hyperin (3), were isolated from Pyrola calliantha (whole plant), together with six structurally related compounds, including 2''-O-galloylhyperin (4), hyperin (5), formononetin (6), quercetin 3-O-alpha-L-arabinopyranoside (7), quercetin 3-O-alpha-L-arabinofuranoside (8), and kaempferol 3-O-beta-D-galactopyranoside (9). The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic (UV, ORD, CD, NMR) and mass-spectrometric (HR-ESI-MS) analyses.

Description

2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage.

Keywords:

2''-O-Galloylhyperin,53209-27-1,Hyperoside 2''-gallate; 3,3',4',5,7-Pentahydroxyflavone 3-β-galactoside 2''-gallate; Quercetin 3-β-galactoside 2''-gallate,Natural Products, buy 2''-O-Galloylhyperin , 2''-O-Galloylhyperin supplier , purchase 2''-O-Galloylhyperin , 2''-O-Galloylhyperin cost , 2''-O-Galloylhyperin manufacturer , order 2''-O-Galloylhyperin , high purity 2''-O-Galloylhyperin

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