Garcinone CCAS# 76996-27-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 76996-27-5 | SDF | Download SDF |
| PubChem ID | 44159808 | Appearance | Yellow powder |
| Formula | C23H26O7 | M.Wt | 414.5 |
| Type of Compound | Xanthones | Storage | Desiccate at -20°C |
| Solubility | Soluble in acetone, chloroform, diethyl ether, ethyl acetate and methanol; practically insoluble in water | ||
| Chemical Name | 1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one | ||
| SMILES | CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)O)CCC(C)(C)O)O)C | ||
| Standard InChIKey | HLOCLVMUASBDDP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H26O7/c1-11(2)5-6-12-14(24)9-17-19(21(12)27)22(28)18-13(7-8-23(3,4)29)20(26)15(25)10-16(18)30-17/h5,9-10,24-27,29H,6-8H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Garcinone C is the most potent inhibitor of AChE. 2. Garcinone C is the most active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). 3. Garcinone C exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. |
| Targets | AChR | Antifection |
Garcinone C Dilution Calculator
Garcinone C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4125 mL | 12.0627 mL | 24.1255 mL | 48.2509 mL | 60.3136 mL |
| 5 mM | 0.4825 mL | 2.4125 mL | 4.8251 mL | 9.6502 mL | 12.0627 mL |
| 10 mM | 0.2413 mL | 1.2063 mL | 2.4125 mL | 4.8251 mL | 6.0314 mL |
| 50 mM | 0.0483 mL | 0.2413 mL | 0.4825 mL | 0.965 mL | 1.2063 mL |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2413 mL | 0.4825 mL | 0.6031 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Euphroside
Catalog No.:BCN6633
CAS No.:76994-07-5
- Notoginsenoside T5
Catalog No.:BCN3727
CAS No.:769932-34-5
- 15-Methoxypinusolidic acid
Catalog No.:BCN4321
CAS No.:769928-72-5
- TPT-260
Catalog No.:BCC5171
CAS No.:769856-81-7
- Cleomiscosin B
Catalog No.:BCN3898
CAS No.:76985-93-8
- Boc-D-2-Nal-OH
Catalog No.:BCC3288
CAS No.:76985-10-9
- H-D-2-Nal-OH.HCl
Catalog No.:BCC3286
CAS No.:76985-09-6
- Nizatidine
Catalog No.:BCC4522
CAS No.:76963-41-2
- Kalii Dehydrographolidi Succinas
Catalog No.:BCN8523
CAS No.:76958-99-1
- DL-alpha-Tocopherylacetate
Catalog No.:BCN2904
CAS No.:7695-91-2
- Cleomiscosin A
Catalog No.:BCN4320
CAS No.:76948-72-6
- Onitin 2'-O-glucoside
Catalog No.:BCN4319
CAS No.:76947-60-9
- Gibberellins
Catalog No.:BCN2189
CAS No.:77-06-5
- Chlorthalidone
Catalog No.:BCC4649
CAS No.:77-36-1
- Ursolic acid
Catalog No.:BCN4327
CAS No.:77-52-1
- Cedrol
Catalog No.:BCN8340
CAS No.:77-53-2
- Tomatidine
Catalog No.:BCN2773
CAS No.:77-59-8
- Tigogenin
Catalog No.:BCN5327
CAS No.:77-60-1
- Trometamol
Catalog No.:BCC4743
CAS No.:77-86-1
- Citric acid
Catalog No.:BCN5374
CAS No.:77-92-9
- Triethyl citrate
Catalog No.:BCC9186
CAS No.:77-93-0
- D-(-)-Quinic acid
Catalog No.:BCN1029
CAS No.:77-95-2
- (+,-)-Octopamine HCl
Catalog No.:BCC4814
CAS No.:770-05-8
- Dehydropachymic acid
Catalog No.:BCN3648
CAS No.:77012-31-8
A new xanthone from the pericarp of Garcinia mangostana.[Pubmed:24555285]
Nat Prod Commun. 2013 Dec;8(12):1733-4.
A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and Garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data. Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.
Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G.[Pubmed:23866810]
BMC Complement Altern Med. 2013 Jul 19;13:182.
BACKGROUND: Leptospirosis, one of the most widespread zoonotic infectious diseases worldwide, is caused by spirochetes bacteria of the genus Leptospira. The present study examined inhibitory activity of purified xanthones and crude extracts from Garcinia mangostana against both non-pathogenic and pathogenic leptospira. Synergy between gamma-mangostin and penicillin G against leptospires was also determined. METHODS: Minimal inhibitory concentrations (MIC) of crude extracts and purified xanthones from G. mangostana and penicillin G for a non-pathogenic (L. biflexa serovar Patoc) and pathogenic (L. interrogans serovar Bataviae, Autumnalis, Javanica and Saigon) leptospires were determined by using broth microdilution method and alamar blue. The synergy was evaluated by calculating the fractional inhibitory concentration (FIC) index. RESULTS: The results of broth microdilution test demonstrated that the crude extract and purified xanthones from mangosteen possessed antileptospiral activities. The crude extracts were active against all five serovars of test leptospira with MICs ranging from 200 to >/= 800 mug/ml. Among the crude extracts and purified xanthones, Garcinone C was the most active compound against both of pathogenic (MIC =100 mug/ml) and non-pathogenic leptospira (MIC = 200 mug/ml). However, these MIC values were higher than those of traditional antibiotics. Combinations of gamma-mangostin with penicillin G generated synergistic effect against L. interrogans serovars Bataviae, Autumnalis and Javanica (FIC = 0.52, 0.50, and 0.04, respectively) and no interaction against L. biflexa serovar Patoc (FIC =0.75). However, antagonistic activity (FIC = 4.03) was observed in L. interrogans serovar Saigon. CONCLUSIONS: Crude extracts and purified xanthones from fruit pericarp of G. mangostana with significant antibacterial activity may be used to control leptospirosis. The combination of xanthone with antibiotic enhances the antileptospiral efficacy.
Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.[Pubmed:25172794]
Phytomedicine. 2014 Sep 25;21(11):1303-9.
Garcinia mangostana is a well-known tropical plant found mostly in South East Asia. The present study investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of G. mangostana extract and its chemical constituents using Ellman's colorimetric method. Cholinesterase inhibitory-guided approach led to identification of six bioactive prenylated xanthones showing moderate to potent cholinesterases inhibition with IC50 values of lower than 20.5 muM. The most potent inhibitor of AChE was Garcinone C while gamma-mangostin was the most potent inhibitor of BChE with IC50 values of 1.24 and 1.78 muM, respectively. Among the xanthones, mangostanol, 3-isomangostin, Garcinone C and alpha-mangostin are AChE selective inhibitors, 8-deoxygartanin is a BChE selective inhibitor while gamma-mangostin is a dual inhibitor. Preliminary structure-activity relationship suggests the importance of the C-8 prenyl and C-7 hydroxy groups for good AChE and BChE inhibitory activities. The enzyme kinetic studies indicate that both alpha-mangostin and Garcinone C are mixed-mode inhibitors, while gamma-mangostin is a non-competitive inhibitor of AChE. In contrast, both gamma-mangostin and Garcinone C are uncompetitive inhibitors, while alpha-mangostin is a mixed-mode inhibitor of BChE. Molecular docking studies revealed that alpha-mangostin, gamma-mangostin and Garcinone C interacts differently with the five important regions of AChE and BChE. The nature of protein-ligand interactions is mainly hydrophobic and hydrogen bonding. These bioactive prenylated xanthones are worthy for further investigations.
