Herpetone

CAS# 951677-22-8

Herpetone

Catalog No. BCN2812----Order now to get a substantial discount!

Product Name & Size Price Stock
Herpetone: 5mg $213 In Stock
Herpetone: 10mg Please Inquire In Stock
Herpetone: 20mg Please Inquire Please Inquire
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Quality Control of Herpetone

Number of papers citing our products

Chemical structure

Herpetone

3D structure

Chemical Properties of Herpetone

Cas No. 951677-22-8 SDF Download SDF
PubChem ID 102004856 Appearance Powder
Formula C29H30O9 M.Wt 522.54
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[5-[(3S,3aR,6S,6aR)-3-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-hydroxy-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)ethanone
SMILES COC1=CC(=CC(=C1O)CC(=O)C2=CC(=C(C=C2)O)OC)C3C4COC(C4CO3)C5=CC(=C(C=C5)O)OC
Standard InChIKey NKRVXSJMQLQTTM-UGOBFYTOSA-N
Standard InChI InChI=1S/C29H30O9/c1-34-24-10-15(4-6-21(24)30)23(32)9-17-8-18(12-26(36-3)27(17)33)29-20-14-37-28(19(20)13-38-29)16-5-7-22(31)25(11-16)35-2/h4-8,10-12,19-20,28-31,33H,9,13-14H2,1-3H3/t19-,20-,28+,29+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Herpetone

The fruits of Herpetospermum pedunculosum

Biological Activity of Herpetone

Description1. Herpetone shows anti-hepatitis B virus (HBV) activity. 2. Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury.
TargetsHBV

Herpetone Dilution Calculator

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Herpetone Molarity Calculator

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Preparing Stock Solutions of Herpetone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9137 mL 9.5686 mL 19.1373 mL 38.2746 mL 47.8432 mL
5 mM 0.3827 mL 1.9137 mL 3.8275 mL 7.6549 mL 9.5686 mL
10 mM 0.1914 mL 0.9569 mL 1.9137 mL 3.8275 mL 4.7843 mL
50 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.7655 mL 0.9569 mL
100 mM 0.0191 mL 0.0957 mL 0.1914 mL 0.3827 mL 0.4784 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Herpetone

Anti-HBV Activities of Three Compounds Extracted and Purified from Herpetospermum Seeds.[Pubmed:28035986]

Molecules. 2016 Dec 27;22(1). pii: molecules22010014.

The goal of this research was to evaluate the anti-hepatitis B virus (HBV) activities of three compounds extracted and purified from Herpetospermum seeds (HS) on HepG2.2.15 cells. Herpetin (HPT), Herpetone (HPO), and herpetfluorenone (HPF) were isolated from HS and identified using HR-ESI-MS and NMR. Different concentrations of the drugs were added to the HepG2.2.15 cells. Cell toxicity was observed with an MTT assay, cell culture supernatants were collected, and HBsAg and HBeAg were detected by ELISA. The content of HBV DNA was determined via quantitative polymerase chain reaction (PCR) with fluorescent probes. The 50% toxicity concentration (TC50) of HPF was 531.48 mug/mL, suggesting that this species is less toxic than HPT and HPO. HPT and HPF showed more potent antiviral activities than HPO. The 50% inhibition concentration (IC50) values of HPF on HBsAg and HBeAg were 176.99 and 134.53 mug/mL, respectively, and the corresponding therapeutic index (TI) values were 2.66 and 3.49, respectively. HPT and HPF were shown to significantly reduce the level of HBV DNA in the HepG2.2.15 culture medium compared to the negative control. This initial investigation of the anti-HBV constituents of HS yielded three compounds that revealed a synergistic effect of multiple components in the ethnopharmacological use of HS.

Two new coumarins from Herpetospermum caudigerum.[Pubmed:18239307]

Chem Pharm Bull (Tokyo). 2008 Feb;56(2):192-3.

The ethyl acetate extract from the seeds of Herpetospermum caudigerum was found to show protective effects on carbon tetrachloride (CCl(4)) and thioacetamide (TAA)-induced acute hepatic injuries in mice. From the ethyl acetate extract, two new coumarins, herpetolide A (1) and herpetolide B (2), along with four known compounds, Herpetone (3), dehydrodiconiferyl alcohol (4), 2,4-dihydroxypyrimidine (5) and stigmasterol (6) were isolated. The structures of the new coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury.

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