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Heteroclitin D

CAS# 140369-76-2

Heteroclitin D

Catalog No. BCN8166----Order now to get a substantial discount!

Product Name & Size Price Stock
Heteroclitin D: 5mg $52 In Stock
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Quality Control of Heteroclitin D

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Chemical structure

Heteroclitin D

3D structure

Chemical Properties of Heteroclitin D

Cas No. 140369-76-2 SDF Download SDF
PubChem ID 10367978 Appearance Powder
Formula C27H30O8 M.Wt 482.5
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,12R,13R,14R)-18,19-dimethoxy-13,14-dimethyl-20-oxo-3,6,8-trioxapentacyclo[9.9.1.01,16.04,21.05,9]henicosa-4(21),5(9),10,16,18-pentaen-12-yl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1C(C(CC2=CC(=C(C(=O)C23COC4=C3C1=CC5=C4OCO5)OC)OC)C)C
Standard InChIKey CGWKMZYZZCWGCK-YSKMNHBWSA-N
Standard InChI InChI=1S/C27H30O8/c1-7-13(2)26(29)35-21-15(4)14(3)8-16-9-18(30-5)23(31-6)25(28)27(16)11-32-24-20(27)17(21)10-19-22(24)34-12-33-19/h7,9-10,14-15,21H,8,11-12H2,1-6H3/b13-7-/t14-,15-,21-,27+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Heteroclitin D

The stems of Kadsura heteroclita

Biological Activity of Heteroclitin D

Description1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor.
TargetsCalcium Channel

Heteroclitin D Dilution Calculator

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Heteroclitin D Molarity Calculator

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Preparing Stock Solutions of Heteroclitin D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0725 mL 10.3627 mL 20.7254 mL 41.4508 mL 51.8135 mL
5 mM 0.4145 mL 2.0725 mL 4.1451 mL 8.2902 mL 10.3627 mL
10 mM 0.2073 mL 1.0363 mL 2.0725 mL 4.1451 mL 5.1813 mL
50 mM 0.0415 mL 0.2073 mL 0.4145 mL 0.829 mL 1.0363 mL
100 mM 0.0207 mL 0.1036 mL 0.2073 mL 0.4145 mL 0.5181 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Heteroclitin D

Blocking effects of heteroclitin D and gomisin J on L-type calcium channels in ventricular cells of guinea pig.[Pubmed:11324471]

Acta Pharmacol Sin. 2000 Apr;21(4):373-6.

AIM: To study the effects of Heteroclitin D (HD) and gomisin J (GJ), two lignans from Kadsura medicinal plants, on L-type calcium channels in ventricular cells of guinea pig. METHODS: The calcium currents were measured by whole-cell patch-clamp recording technique. RESULTS: HD 1 and 10 mumol/L decreased the L-type calcium current from (770 +/- 155) to (482 +/- 104) and (384 +/- 85) pA, respectively. GJ 10 mumol/L inhibited calcium current from (822 +/- 169) to (436 +/- 143) pA. Neither HD nor GJ affected the steady-state activation curve. But they had impact on steady-state inactivation curve. HD 10 mumol/L changed the half inactivation voltage (V0.5) from -22.7 to -40.9 mV, and slope factor (kappa) from 10.2 to 20.6 (n = 4 cells from 3 guinea pigs, P < 0.05). GJ 10 mumol/L changed the V0.5 from -17.7 to -33.3 mV, and kappa from 15.9 to 27.8 (n = 5 cells from 3 guinea pigs, P < 0.05). CONCLUSION: HD and GJ inhibited L-type calcium channels.

Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.[Pubmed:12350139]

J Nat Prod. 2002 Sep;65(9):1242-5.

Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), Heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.

Description

Heteroclitin D is a lignin from Kadsura medicinal plants with anti-liqid peroxidation. Heteroclitin D inhibits L-type calcium channels.

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