Vancomycin hydrochlorideAntibiotic CAS# 1404-93-9 |
- Dofequidar
Catalog No.:BCC4176
CAS No.:129716-58-1
- Elacridar
Catalog No.:BCC1546
CAS No.:143664-11-3
- Elacridar hydrochloride
Catalog No.:BCC1547
CAS No.:143851-98-3
- LY335979 (Zosuquidar 3HCL)
Catalog No.:BCC3878
CAS No.:167465-36-3
- Tariquidar
Catalog No.:BCC3625
CAS No.:206873-63-4
- Tariquidar methanesulfonate, hydrate
Catalog No.:BCC1986
CAS No.:625375-83-9
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1404-93-9 | SDF | Download SDF |
| PubChem ID | 6420023 | Appearance | Powder |
| Formula | C66H75Cl2N9O24 | M.Wt | 1449.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : 33.33 mg/mL (22.43 mM; Need ultrasonic) DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming) | ||
| Chemical Name | (1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid;hydrochloride | ||
| SMILES | CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl | ||
| Standard InChIKey | LCTORFDMHNKUSG-XTTLPDOESA-N | ||
| Standard InChI | InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Antibiotic with activity against Gram-positive bacteria. |
Vancomycin hydrochloride Dilution Calculator
Vancomycin hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.69 mL | 3.4499 mL | 6.8999 mL | 13.7998 mL | 17.2497 mL |
| 5 mM | 0.138 mL | 0.69 mL | 1.38 mL | 2.76 mL | 3.4499 mL |
| 10 mM | 0.069 mL | 0.345 mL | 0.69 mL | 1.38 mL | 1.725 mL |
| 50 mM | 0.0138 mL | 0.069 mL | 0.138 mL | 0.276 mL | 0.345 mL |
| 100 mM | 0.0069 mL | 0.0345 mL | 0.069 mL | 0.138 mL | 0.1725 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Vancomycin hydrochloride is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.
- 6'-O-Cinnamoyl-8-epikingisidic acid
Catalog No.:BCN7059
CAS No.:1403984-03-1
- Nexturastat A
Catalog No.:BCC5345
CAS No.:1403783-31-2
- PFI-1 (PF-6405761)
Catalog No.:BCC2225
CAS No.:1403764-72-6
- Heteroclitin D
Catalog No.:BCN8166
CAS No.:140369-76-2
- Macranthoidin A
Catalog No.:BCN2808
CAS No.:140360-29-8
- EPZ-6438
Catalog No.:BCC3634
CAS No.:1403254-99-8
- Squalene-2,3-diol
Catalog No.:BCN6220
CAS No.:14031-37-9
- Chetomin
Catalog No.:BCC2432
CAS No.:1403-36-7
- NLG919
Catalog No.:BCC2325
CAS No.:1402836-58-1
- N-Methyllindcarpine
Catalog No.:BCN6218
CAS No.:14028-97-8
- Amoxapine
Catalog No.:BCC4624
CAS No.:14028-44-5
- Boc-Lys(2-Cl-Z)-ol
Catalog No.:BCC2581
CAS No.:14028-05-8
- RSVA 405
Catalog No.:BCC8016
CAS No.:140405-36-3
- CCT244747
Catalog No.:BCC6423
CAS No.:1404095-34-6
- ON 146040
Catalog No.:BCC8058
CAS No.:1404231-34-0
- 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Catalog No.:BCC1086
CAS No.:140430-53-1
- Fmoc-Dap(Dnp)-OH
Catalog No.:BCC2666
CAS No.:140430-54-2
- ML 281
Catalog No.:BCC6317
CAS No.:1404437-62-2
- GSK 2830371
Catalog No.:BCC4179
CAS No.:1404456-53-6
- 11-Hydroxyjasmonic acid
Catalog No.:BCN6221
CAS No.:140447-14-9
- Ergosterol peroxide glucoside
Catalog No.:BCN6222
CAS No.:140447-22-9
- Heteroclitin C
Catalog No.:BCN3632
CAS No.:140460-42-0
- Heteroclitin B
Catalog No.:BCN3745
CAS No.:140461-47-8
- Olopatadine HCl
Catalog No.:BCC4545
CAS No.:140462-76-6
Long-term Stability of Vancomycin Hydrochloride in Oral Solution: The Brand Name Versus a Generic Product.[Pubmed:28333681]
Int J Pharm Compd. 2016 Jul-Aug;20(4):347-350.
Vancomycin hydrochloride is often used for antibiotherapy in oral solution for hospitalized patients. Preparation of this solution in advance could improve time management or cost savings of drug delivery. Brand and generic products of Vancomycin hydrochloride are now commercially available. The aim of this study was to investigate the long-term stability of the Vancomycin hydrochloride brand name Vancocin versus the generic Vancomycine at 5 degrees C +/- 3 degrees C. Five vials of each oral solution of 1.25 g/100 mL Vancocin and Vancomycine were stored up to 57 days at 5 degrees C +/- 3 degrees C. Concentrations were measured by high-performance liquid chromatography-diode array detection. Visual inspection by microscopy and spectrophotometry, as well as pH measurement, were performed periodically during the storage period. No color change or precipitation in the solution was observed throughout the study period. The lower confidence limit of the concentration for these solutions remained superior to 90% of the initial concentration as recommended by the U.S. Food and Drug Administration up to a 57-day storage period for Vancocin (106.47%) and vancomycin (102.73%). The solutions prepared either from brand or generic Vancomycin hydrochloride were chemically stable for more than one month and could be prepared in advance.
Use of 8.4% Sodium Bicarbonate in Buffering Commonly Administered Vancomycin Hydrochloride Solutions for Use with Midline or Peripheral Line Catheters.[Pubmed:26625570]
Int J Pharm Compd. 2015 Jul-Aug;19(4):334-6.
The primary objective of this study was to evaluate the use of 8.4% sodium bicarbonate in the buffering of commonly administered Vancomycin hydrochloride solutions for use with midline or peripheral line catheters. Nine admixtures of Vancomycin hydrochloride were aseptically prepared for this study. Vancomycin hydrochloride solutions were prepared in triplicates in the following strengths, 1 gram, 2 grams, and 3 grams, which were added to 250-mL bags of sodium chloride 0.9% injection (with overfill). To each prepared solution of Vancomycin hydrochloride, 0.5 mL of 8.4% sodium bicarbonate was added. The pH was measured to obtain a baseline level. At day 9, the pH of each sample was measured and compared to those at baseline. The osmolality of each sample was also measured. There was no statistical difference in the pH at baseline and at day 9 (alpha = 0.05, P = 0.347). A solution of Vancomycin hydrochloride that is compounded in 250 mL of sodium chloride 0.9% injection (including overfill) and buffered with 0.5 mL of 8.4% sodium bicarbonate maintained a pH in the range of 5 to 9 and an osmolality in the range of 150 mOsm/kg to 500 mOsm/kg.
Design and evaluation of gamma-sterilized vancomycin hydrochloride-loaded poly(varepsilon-caprolactone) microspheres for the treatment of biofilm-based medical device-related osteomyelitis.[Pubmed:26498171]
Pharm Dev Technol. 2017 Sep;22(6):706-714.
CONTEXT: There is a great necessity to find and use accomplished terminal sterilization technique for industrial manufacturing, research and development studies. Gamma (gamma)-sterilization has been commonly employed for wide range of products as indicated by the pharmacopoeias. However, carefully examination should be performed prior to administration since gamma-radiation can cause changes in drug and polymer excipients. No information is available in literature about gamma-sterilization effects on vancomycin HCl-loaded poly (varepsilon-caprolactone) (PCL) microspheres. OBJECTIVE: Formulations were developed using a different preparation approach for the treatment of medical device-related osteomyelitis, and gamma-sterilization effects on the physicochemical characterization of the formulations were examined. METHODS: Water-in-oil-in-water (w/o/w) emulsion technique using polyvinyl alcohol (PVA) in inner and outer phase was applied to prepare formulations. Physicochemical properties of the formulations were investigated before and after gamma-sterilization and the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) were measured. RESULTS: The particle size of the nonsterilized formulations were between 58 and 134 mum. 60% or 20% of vancomycin HCl were released from 42.500 Mn or 70.000-90.000 Mn PCL microspheres, respectively, in 24 h. No difference was observed in the particle size, drug-loading efficiency, morphology, in vitro release and antimicrobial activity of the formulations after gamma-sterilization (p > 0.05).
Long-term Stability of Vancomycin Hydrochloride in Glucose 5% Polyolefin Bags: The Brand Name Versus a Generic Product.[Pubmed:28339376]
Int J Pharm Compd. 2016 Sep-Oct;20(5):416-420.
The objectives of this study were to determine if the preparation of Vancomycin hydrochloride in advance of infusion could improve the quality of the drug, time management of drug delivery, cost savings of drug delivery, and to investigate the long-term stability of Vancomycin hydrochloride (brand name Vancocin(R)) infusion in glucose 5% polyolefin bags versus the generic (Vancomycine(R)) at 5 degrees C +/- 3 degrees C. Five bags of each infusion 1 g/100 mL Vancomycin hydrochloride in 5% glucose (Vancocin (R) and Vancomycine(R)) were stored up to 57 days at 5 degrees C +/- 3 degrees C. A visual inspection and pH measurement were performed periodically during the storage, and the concentrations were measured by high-performance liquid chromatography-diode array detection. No color change or precipitation in the solution was observed throughout the study period. As recommended by the U.S. Food and Drug Administration, the lower confidence limit at 95% of the concentration for the solutions remained superior to 90% of the initial concentration up to 43 days for the brand vancomycin (Vancocin(R)) infusion (96% +/- 2%) and up to 57 days for the generic (Vancomycine(R)) (95% +/- 4%). The solutions prepared either from brand or generic Vancomycin hydrochloride were chemically stable more than one month (43 days for the brand and 57 days for the generic solution) and could be prepared in advance in a centralized intravenous additive service facility.
