ON 146040CAS# 1404231-34-0 |
Related Products
- Vinblastine Sulfate
Catalog No.:BCN2292
CAS No.:143-67-9
- Doxorubicin
Catalog No.:BCC2082
CAS No.:23214-92-8
- Pepstatin A
Catalog No.:BCC1218
CAS No.:26305-03-3
- Dexamethasone (DHAP)
Catalog No.:BCC1184
CAS No.:50-02-2
- E 64d
Catalog No.:BCC1127
CAS No.:88321-09-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1404231-34-0 | SDF | Download SDF |
PubChem ID | 73297262 | Appearance | Powder |
Formula | C24H23N7O3S | M.Wt | 489.55 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in DMSO | ||
Chemical Name | (7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one | ||
SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=N3)SC(=CC5=CC=C(C=C5)[N+](=O)[O-])C(=O)N4 | ||
Standard InChIKey | PKCHFYZACODWAI-STZFKDTASA-N | ||
Standard InChI | InChI=1S/C24H23N7O3S/c1-29-10-12-30(13-11-29)18-8-4-17(5-9-18)26-24-25-15-20-23(28-24)35-21(22(32)27-20)14-16-2-6-19(7-3-16)31(33)34/h2-9,14-15H,10-13H2,1H3,(H,27,32)(H,25,26,28)/b21-14- | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).In Vitro:In biochemical testing, ON 146040 inhibits PI3Kα/ PI3Kδ isoforms (IC50≈14 and 20 nM, respectively) without having a major effect on PI3Kβ/ PI3Kγ isoforms (IC50≈3 and 1 μM, respectively). ON 146040 is also found to inhibit Abl1 and several mutant versions of this kinase (IC50<150 nM), although ON 146040 is not found to be active against the T315I mutant. ON 146040 represents the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways. ON 146040 disrupts the oncogenic activity of both STAT3 and STAT5 by targeting upstream activators, including PI3K α and δ isoforms as well as wild type and mutant BCR-ABL. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation are down-regulated in leukemia and myeloma cells[1]. References: |
ON 146040 Dilution Calculator
ON 146040 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.0427 mL | 10.2135 mL | 20.4269 mL | 40.8538 mL | 51.0673 mL |
5 mM | 0.4085 mL | 2.0427 mL | 4.0854 mL | 8.1708 mL | 10.2135 mL |
10 mM | 0.2043 mL | 1.0213 mL | 2.0427 mL | 4.0854 mL | 5.1067 mL |
50 mM | 0.0409 mL | 0.2043 mL | 0.4085 mL | 0.8171 mL | 1.0213 mL |
100 mM | 0.0204 mL | 0.1021 mL | 0.2043 mL | 0.4085 mL | 0.5107 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.
Featured Products
- CCT244747
Catalog No.:BCC6423
CAS No.:1404095-34-6
- RSVA 405
Catalog No.:BCC8016
CAS No.:140405-36-3
- Vancomycin hydrochloride
Catalog No.:BCC4232
CAS No.:1404-93-9
- 6'-O-Cinnamoyl-8-epikingisidic acid
Catalog No.:BCN7059
CAS No.:1403984-03-1
- Nexturastat A
Catalog No.:BCC5345
CAS No.:1403783-31-2
- PFI-1 (PF-6405761)
Catalog No.:BCC2225
CAS No.:1403764-72-6
- Heteroclitin D
Catalog No.:BCN8166
CAS No.:140369-76-2
- Macranthoidin A
Catalog No.:BCN2808
CAS No.:140360-29-8
- EPZ-6438
Catalog No.:BCC3634
CAS No.:1403254-99-8
- Squalene-2,3-diol
Catalog No.:BCN6220
CAS No.:14031-37-9
- Chetomin
Catalog No.:BCC2432
CAS No.:1403-36-7
- NLG919
Catalog No.:BCC2325
CAS No.:1402836-58-1
New Products
- 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Catalog No.:BCC1086
CAS No.:140430-53-1
- Fmoc-Dap(Dnp)-OH
Catalog No.:BCC2666
CAS No.:140430-54-2
- ML 281
Catalog No.:BCC6317
CAS No.:1404437-62-2
- GSK 2830371
Catalog No.:BCC4179
CAS No.:1404456-53-6
- 11-Hydroxyjasmonic acid
Catalog No.:BCN6221
CAS No.:140447-14-9
- Ergosterol peroxide glucoside
Catalog No.:BCN6222
CAS No.:140447-22-9
- Heteroclitin C
Catalog No.:BCN3632
CAS No.:140460-42-0
- Heteroclitin B
Catalog No.:BCN3745
CAS No.:140461-47-8
- Olopatadine HCl
Catalog No.:BCC4545
CAS No.:140462-76-6
- Neomycin sulfate
Catalog No.:BCC4682
CAS No.:1405-10-3
- Capreomycin Sulfate
Catalog No.:BCC4644
CAS No.:1405-37-4
- Gentamycin Sulfate
Catalog No.:BCC1203
CAS No.:1405-41-0
ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
ON 146040,1404231-34-0,Natural Products,Bcr-Abl, buy ON 146040 , ON 146040 supplier , purchase ON 146040 , ON 146040 cost , ON 146040 manufacturer , order ON 146040 , high purity ON 146040