Eupalinolide ICAS# 1402067-84-8 |
- Eupalinolide B
Catalog No.:BCN2525
CAS No.:877822-40-7
- Eupalinolide A
Catalog No.:BCN2524
CAS No.:877822-41-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1402067-84-8 | SDF | Download SDF |
PubChem ID | 131847725 | Appearance | Oil |
Formula | C24H30O9 | M.Wt | 462.49 |
Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | [(3aR,4R,6E,9R,10E,11aR)-9-acetyloxy-6-(acetyloxymethyl)-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate | ||
SMILES | CC1=CC2C(C(CC(=CCC1OC(=O)C)COC(=O)C)OC(=O)C(=CCO)C)C(=C)C(=O)O2 | ||
Standard InChIKey | HPWMABTYJYZFLK-KPPLFFIBSA-N | ||
Standard InChI | InChI=1S/C24H30O9/c1-13(8-9-25)23(28)32-21-11-18(12-30-16(4)26)6-7-19(31-17(5)27)14(2)10-20-22(21)15(3)24(29)33-20/h6,8,10,19-22,25H,3,7,9,11-12H2,1-2,4-5H3/b13-8+,14-10+,18-6+/t19-,20-,21-,22+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Targets | STAT |
Eupalinolide I Dilution Calculator
Eupalinolide I Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.1622 mL | 10.811 mL | 21.6221 mL | 43.2442 mL | 54.0552 mL |
5 mM | 0.4324 mL | 2.1622 mL | 4.3244 mL | 8.6488 mL | 10.811 mL |
10 mM | 0.2162 mL | 1.0811 mL | 2.1622 mL | 4.3244 mL | 5.4055 mL |
50 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 0.8649 mL | 1.0811 mL |
100 mM | 0.0216 mL | 0.1081 mL | 0.2162 mL | 0.4324 mL | 0.5406 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Psiguadial D
Catalog No.:BCN7086
CAS No.:1402066-95-8
- GSK2879552
Catalog No.:BCC6422
CAS No.:1401966-69-5
- Vc-MMAD
Catalog No.:BCC2032
CAS No.:1401963-17-4
- Mc-MMAD
Catalog No.:BCC1735
CAS No.:1401963-15-2
- (S)-(-)-5-Iodowillardiine
Catalog No.:BCC6597
CAS No.:140187-25-3
- (S)-(-)-5-Fluorowillardiine
Catalog No.:BCC6596
CAS No.:140187-23-1
- Monnieriside A
Catalog No.:BCN7892
CAS No.:1401807-73-5
- Monnieriside G
Catalog No.:BCN7857
CAS No.:1401799-34-5
- (-)-Praeruptorin A
Catalog No.:BCN7664
CAS No.:14017-71-1
- Negundonorin A
Catalog No.:BCN7150
CAS No.:1401618-51-6
- ATPA
Catalog No.:BCC6940
CAS No.:140158-50-5
- Epimedin A1
Catalog No.:BCN5935
CAS No.:140147-77-9
- TUG-770
Catalog No.:BCC2018
CAS No.:1402601-82-4
- Boc-Lys(2-Cl-Z)-ol
Catalog No.:BCC2581
CAS No.:14028-05-8
- Amoxapine
Catalog No.:BCC4624
CAS No.:14028-44-5
- N-Methyllindcarpine
Catalog No.:BCN6218
CAS No.:14028-97-8
- NLG919
Catalog No.:BCC2325
CAS No.:1402836-58-1
- Chetomin
Catalog No.:BCC2432
CAS No.:1403-36-7
- Squalene-2,3-diol
Catalog No.:BCN6220
CAS No.:14031-37-9
- EPZ-6438
Catalog No.:BCC3634
CAS No.:1403254-99-8
- Macranthoidin A
Catalog No.:BCN2808
CAS No.:140360-29-8
- Heteroclitin D
Catalog No.:BCN8166
CAS No.:140369-76-2
- PFI-1 (PF-6405761)
Catalog No.:BCC2225
CAS No.:1403764-72-6
- Nexturastat A
Catalog No.:BCC5345
CAS No.:1403783-31-2
Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed:29086600]
Nat Prod Res. 2017 Oct 31:1-9.
Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC). In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.