Epimedin A1CAS# 140147-77-9 |
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| Cas No. | 140147-77-9 | SDF | Download SDF |
| PubChem ID | 92043273 | Appearance | Yellow crystals |
| Formula | C39H50O20 | M.Wt | 838.8 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Hexandraside F | ||
| Solubility | DMSO : 150 mg/mL (178.83 mM; Need ultrasonic and warming) | ||
| Chemical Name | 3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
| SMILES | CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)OC6C(C(C(C(O6)CO)O)O)O)O | ||
| Standard InChIKey | NLVBYGTTYRFJKH-YFNAFYFCSA-N | ||
| Standard InChI | InChI=1S/C39H50O20/c1-14(2)5-10-18-20(54-37-30(49)28(47)25(44)21(12-40)55-37)11-19(42)23-27(46)36(33(57-34(18)23)16-6-8-17(52-4)9-7-16)59-39-32(51)35(24(43)15(3)53-39)58-38-31(50)29(48)26(45)22(13-41)56-38/h5-9,11,15,21-22,24-26,28-32,35,37-45,47-51H,10,12-13H2,1-4H3/t15-,21+,22+,24-,25+,26+,28-,29-,30+,31+,32+,35+,37+,38-,39-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
1 Jasminum sp. 2 Lonicera sp. 3 Olea sp. 4 Rhododendron sp. 5 Saussurea sp. 6 Stereospermum sp.
| Description | 1. Epimedin A1 has anti-osteoporosis activity. |
Epimedin A1 Dilution Calculator
Epimedin A1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1922 mL | 5.9609 mL | 11.9218 mL | 23.8436 mL | 29.8045 mL |
| 5 mM | 0.2384 mL | 1.1922 mL | 2.3844 mL | 4.7687 mL | 5.9609 mL |
| 10 mM | 0.1192 mL | 0.5961 mL | 1.1922 mL | 2.3844 mL | 2.9804 mL |
| 50 mM | 0.0238 mL | 0.1192 mL | 0.2384 mL | 0.4769 mL | 0.5961 mL |
| 100 mM | 0.0119 mL | 0.0596 mL | 0.1192 mL | 0.2384 mL | 0.298 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Determination of flavonoids constituents in epimedium total flavone capsule and research on its anti-osteoporosis activity].[Pubmed:30200709]
Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(15):3140-3144.
To develop a rapid resolution liquid chromatography (RRLC) method for the simultaneous determination of epimedoside A, Epimedin A1, epimedin A, epimedin B, epimedin C, icariin, baohuoside, icariside, sagittatoside B, 2"-O-rhamnosyl icariside, and baohuosidein epimedium total flavone capsule. At the same time, the effects of the above 11 compounds on osteogenic differentiation of MC3T3-E1 cells were investigated by detecting the content of alkaline phosphatase (AKP). The results showed that baohuoside had the highest activities, and both the activities of baohuoside and icariside were stronger than those of icariin.In this study, the content determination method of flavonoid glycosides was established, and the anti-osteoporosis effect of monomers was compared, providing technical support for the study of the pharmacodynamic and mechanism of Epimedium total flavone capsule.
Epimedin A1 is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.
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