Epimedin A1

CAS# 140147-77-9

Epimedin A1

Catalog No. BCN5935----Order now to get a substantial discount!

Product Name & Size Price Stock
Epimedin A1: 5mg $40 In Stock
Epimedin A1: 10mg Please Inquire In Stock
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Quality Control of Epimedin A1

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Chemical structure

Epimedin A1

3D structure

Chemical Properties of Epimedin A1

Cas No. 140147-77-9 SDF Download SDF
PubChem ID 92043273 Appearance Yellow crystals
Formula C39H50O20 M.Wt 838.8
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Hexandraside F
Solubility DMSO : 150 mg/mL (178.83 mM; Need ultrasonic and warming)
Chemical Name 3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
SMILES CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)OC6C(C(C(C(O6)CO)O)O)O)O
Standard InChIKey NLVBYGTTYRFJKH-YFNAFYFCSA-N
Standard InChI InChI=1S/C39H50O20/c1-14(2)5-10-18-20(54-37-30(49)28(47)25(44)21(12-40)55-37)11-19(42)23-27(46)36(33(57-34(18)23)16-6-8-17(52-4)9-7-16)59-39-32(51)35(24(43)15(3)53-39)58-38-31(50)29(48)26(45)22(13-41)56-38/h5-9,11,15,21-22,24-26,28-32,35,37-45,47-51H,10,12-13H2,1-4H3/t15-,21+,22+,24-,25+,26+,28-,29-,30+,31+,32+,35+,37+,38-,39-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epimedin A1

1 Jasminum sp. 2 Lonicera sp. 3 Olea sp. 4 Rhododendron sp. 5 Saussurea sp. 6 Stereospermum sp.

Biological Activity of Epimedin A1

Description1. Epimedin A1 has anti-osteoporosis activity.

Epimedin A1 Dilution Calculator

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Epimedin A1 Molarity Calculator

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Preparing Stock Solutions of Epimedin A1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1922 mL 5.9609 mL 11.9218 mL 23.8436 mL 29.8045 mL
5 mM 0.2384 mL 1.1922 mL 2.3844 mL 4.7687 mL 5.9609 mL
10 mM 0.1192 mL 0.5961 mL 1.1922 mL 2.3844 mL 2.9804 mL
50 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.4769 mL 0.5961 mL
100 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2384 mL 0.298 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Epimedin A1

[Determination of flavonoids constituents in epimedium total flavone capsule and research on its anti-osteoporosis activity].[Pubmed:30200709]

Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(15):3140-3144.

To develop a rapid resolution liquid chromatography (RRLC) method for the simultaneous determination of epimedoside A, Epimedin A1, epimedin A, epimedin B, epimedin C, icariin, baohuoside, icariside, sagittatoside B, 2"-O-rhamnosyl icariside, and baohuosidein epimedium total flavone capsule. At the same time, the effects of the above 11 compounds on osteogenic differentiation of MC3T3-E1 cells were investigated by detecting the content of alkaline phosphatase (AKP). The results showed that baohuoside had the highest activities, and both the activities of baohuoside and icariside were stronger than those of icariin.In this study, the content determination method of flavonoid glycosides was established, and the anti-osteoporosis effect of monomers was compared, providing technical support for the study of the pharmacodynamic and mechanism of Epimedium total flavone capsule.

Description

Epimedin A1 is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.

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