Epimedin BCAS# 110623-73-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 110623-73-9 | SDF | Download SDF |
| PubChem ID | 5748393 | Appearance | Yellow powder |
| Formula | C38H48O19 | M.Wt | 808.78 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 33.33 mg/mL (41.21 mM; Need ultrasonic) | ||
| Chemical Name | 3-[(2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
| SMILES | CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)OC6C(C(C(CO6)O)O)O)O)O | ||
| Standard InChIKey | OCZZCFAOOWZSRX-LRHLXKJSSA-N | ||
| Standard InChI | InChI=1S/C38H48O19/c1-14(2)5-10-18-21(53-37-31(49)28(46)26(44)22(12-39)54-37)11-19(40)23-27(45)34(32(55-33(18)23)16-6-8-17(50-4)9-7-16)56-38-35(29(47)24(42)15(3)52-38)57-36-30(48)25(43)20(41)13-51-36/h5-9,11,15,20,22,24-26,28-31,35-44,46-49H,10,12-13H2,1-4H3/t15-,20+,22+,24-,25-,26+,28-,29+,30+,31+,35+,36-,37+,38-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Epimedin A,epimendin B, epimendin C, icariin and baohuoside are flavonoids, main active ingredient in Epimedium, have clear anti-osteoporosis effect, the accumulation of epimedins A, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress. |
| In vitro | Light stress suppresses the accumulation of epimedins A, B, C, and icariin in Epimedium, a traditional medicinal plant.[Reference: WebLink]Acta Physiol Plant, 2013, 35(11):3271-5.Epimedium is well-known in China and East Asia due to high content of flavonoid derivatives, including icariin, epimedin A, Epimedin B, and epimedin C, hereafter designated as bioactive components, which have been extensively utilized to cure many diseases. So far, the molecular mechanism of the bioactive components biosynthesis remains unclear.
|
| Kinase Assay | Study on Different Factors Affecting the Bionic Enzymatic Hydrolysis of Icariin,Epimedin A,Epimendin B,Epimendin C and Eplmedium Flavonolds.[Reference: WebLink]National Symposium on Chinese medicine and natural medicine. 2014.Flavonoids were the main active ingredient in Epimedium and mainly included icariin,epimedin A,epimendin B,epimendin C and baohuoside.Modern pharmacological studies have shown that Epimedium flavone had clear anti-osteoporosis effect.
In order to obtain an improved absorption,transformation to secondary glycosides by intestinal enzymes and intestinal bacteria is necessary after the oral administration[1].However,intestinal enzymes and intestinal bacteria were unstable and could be affected by race,age,diet and medication[2].To screen effective and safe hydrolase in vitro and add it to epimedium flavone preparation could promote oral absorption of epimedium flavonoids,increase its bioavailability and improve its efficacy.
|
| Structure Identification | Nat Prod Res. 2015;29(2):185-8.Simultaneous enrichment and separation of flavonoids from Herba Epimedii by macroporous resins coupled with preparative chromatographic method.[Pubmed: 25277166]
|
Epimedin B Dilution Calculator
Epimedin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2364 mL | 6.1822 mL | 12.3643 mL | 24.7286 mL | 30.9108 mL |
| 5 mM | 0.2473 mL | 1.2364 mL | 2.4729 mL | 4.9457 mL | 6.1822 mL |
| 10 mM | 0.1236 mL | 0.6182 mL | 1.2364 mL | 2.4729 mL | 3.0911 mL |
| 50 mM | 0.0247 mL | 0.1236 mL | 0.2473 mL | 0.4946 mL | 0.6182 mL |
| 100 mM | 0.0124 mL | 0.0618 mL | 0.1236 mL | 0.2473 mL | 0.3091 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Epimedin B, a component extracted from Epimedii Folium, is reported to have antiosteoporotic activity. IC50 value: Target: In vitro: In vivo: Prednisolone-induced osteoporosis model using zebrafish was used to evaluate the antiosteoporotic activity of micro amount epimedin B. The result showed that 1 μmol·L- 1epimedin B groups were significantly increased when compared with model group; Epimedin B can prevent zebrafish osteoporosis induced by prednisolone [1].
References:
[1]. ZHAN Yang, et al. Evaluation of Antiosteoporotic Activity for Micro Amount Icariin and Epimedin B Based on the Osteoporosis Model Using Zebrafish. Chinese Pharmaceutical Journal, 2014-01
[2]. Cui L, et al. Metabolite profiles of epimedin B in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Agric Food Chem. 2013 Apr 17;61(15):3589-99.
[3]. ZHANG Hua-feng, et al. Effects of microwave radiation on extraction of epimedin B from Epimedii Folium. Chinese Traditional and Herbal Drugs, 2011-09
- Epimedin A
Catalog No.:BCN1038
CAS No.:110623-72-8
- human Insulin expressed in yeast
Catalog No.:BCC7689
CAS No.:11061-68-0
- Laminin (925-933)
Catalog No.:BCC1015
CAS No.:110590-60-8
- Salermide
Catalog No.:BCC7867
CAS No.:1105698-15-4
- Albrassitriol
Catalog No.:BCN7274
CAS No.:110557-39-6
- Scutebarbatine F
Catalog No.:BCN5377
CAS No.:910099-78-4
- 6,11-Di-O-acetylalbrassitriol
Catalog No.:BCN7273
CAS No.:110538-20-0
- Crotastriatine
Catalog No.:BCN2101
CAS No.:11051-94-8
- BYK 204165
Catalog No.:BCC2449
CAS No.:1104546-89-5
- ML-7 hydrochloride
Catalog No.:BCC1770
CAS No.:110448-33-4
- Dolastatin 10
Catalog No.:BCC4056
CAS No.:110417-88-4
- Gelsemiol
Catalog No.:BCN5992
CAS No.:110414-77-2
- Epimedin C
Catalog No.:BCN1040
CAS No.:110642-44-9
- beta-Escin
Catalog No.:BCC8172
CAS No.:11072-93-8
- Asebotin
Catalog No.:BCN7233
CAS No.:11075-15-3
- Garcinexanthone A
Catalog No.:BCN5993
CAS No.:1107620-67-6
- Cinobufotalin
Catalog No.:BCN2283
CAS No.:1108-68-5
- MCOPPB trihydrochloride
Catalog No.:BCC4161
CAS No.:1108147-88-1
- Sparfloxacin
Catalog No.:BCC4848
CAS No.:110871-86-8
- Entrectinib
Catalog No.:BCC6410
CAS No.:1108743-60-7
- Wilforine
Catalog No.:BCN5994
CAS No.:11088-09-8
- [Sar9,Met(O2)11]-Substance P
Catalog No.:BCC6960
CAS No.:110880-55-2
- Tunicamycin
Catalog No.:BCC7699
CAS No.:11089-65-9
- PF-04620110
Catalog No.:BCC2335
CAS No.:1109276-89-2
Simultaneous enrichment and separation of flavonoids from Herba Epimedii by macroporous resins coupled with preparative chromatographic method.[Pubmed:25277166]
Nat Prod Res. 2015;29(2):185-8.
An efficient, feasible enrichment and separation method of epimedins A, B, C and icariin from Herba Epimedii was developed by the combination of microwave-assisted extraction, macroporous resins and preparative HPLC. WDX-5 macroporous resin shows better recoveries at 96.2%, 97.0%, 98.2% and 97.1% for epimedins A, B, C and icariin than other macroporous resins used in the experiments. As a result, epimedins A (5.1 mg), B (15.3 mg), C (7.6 mg) and icariin (14.3 mg) were obtained from 6.0 g crude Herba Epimedii with the recoveries at 70.8%, 68.9%, 66.7% and 95.3%, respectively. The method developed in this study may provide scientific references for the enrichment and separation of flavonoids from Herba Epimedii.
[Simultaneous assay of epimedin A epimedin B, epimedin C and icariin in herba epimedii by QAMS].[Pubmed:21438397]
Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(24):3310-3.
OBJECTIVE: To establish a new method and validate its feasibilities for quality evaluation of Fructus Epimedii. METHOD: Four main effective flavones, epimedin A, Epimedin B, epimedin C and icariin were selected as analytes to evaluate the quality of Fructus Epimedii. The relative correction factors (RCF) of icariin to the other three flavones were calculated. The method was evaluated by comparison of the quantitative results between external standard method and QAMS method. RESULT: No significant differences were found in the quantitative results of three flavones by external standard method and QAMS method. CONCLUSION: It is feasible and accurate to evaluate the quality of Fructus Epimedii.
