Epimedin B1

CAS# 133137-58-3

Epimedin B1

Catalog No. BCN8199----Order now to get a substantial discount!

Product Name & Size Price Stock
Epimedin B1: 5mg $311 In Stock
Epimedin B1: 10mg Please Inquire In Stock
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Quality Control of Epimedin B1

Number of papers citing our products

Chemical structure

Epimedin B1

3D structure

Chemical Properties of Epimedin B1

Cas No. 133137-58-3 SDF Download SDF
PubChem ID 14704539 Appearance Yellow Powder
Formula C38H48O19 M.Wt 808.8
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
SMILES CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)OC6C(C(C(CO6)O)O)O
Standard InChIKey JPSGKKBWCDWJSN-AUAMDOBLSA-N
Standard InChI InChI=1S/C38H48O19/c1-14(2)5-10-18-21(53-38-30(48)27(45)25(43)22(12-39)54-38)11-19(40)23-26(44)35(33(55-34(18)23)16-6-8-17(50-4)9-7-16)57-37-31(49)28(46)32(15(3)52-37)56-36-29(47)24(42)20(41)13-51-36/h5-9,11,15,20,22,24-25,27-32,36-43,45-49H,10,12-13H2,1-4H3/t15-,20+,22+,24-,25+,27-,28-,29+,30+,31+,32-,36-,37-,38+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epimedin B1

The herbs of Epimedium sagittatum

Biological Activity of Epimedin B1

In vitro

Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model.[Reference: WebLink]

Molecules, 2014, 19(1):686-698.

Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedin A, Epimedin B(Epimedin B1 ), and Epimedin C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures.
METHODS AND RESULTS:
In this study, the intestinal absorption mechanism of these three compounds was investigated using the Caco-2 cell monolayer model in both the apical-to-basolateral (A-B) and the basolateral-to-apical (B-A) direction. The absorption permeability (PAB) of epimedin A, epimedin B0, and epimedin C were extremely low and increased as the concentration of the epimedins increased from 5 to 20 μM, but, at 40 μM, the PAB values were reduced. Meanwhile, the amount of transported compounds increased in a time-dependent manner. The PAB of epimedins A and C were significantly increased and efflux ratios decreased in the presence of verapamil (an inhibitor of P-glycoprotein) and dipyridamole (an inhibitor of breast cancer resistance protein) while, in the presence of MK571 (an inhibitor of multidrug resistance proteins), the absorption of epimedins A and C did not change significantly, indicating that P-gp and BCRP might be involved in the transport of epimedins A and C. The PAB of epimedin B significantly increased while its secretory permeability (PBA) significantly decreased in the presence of dipyridamole, indicating that BCRP might be involved in the transport of epimedin B. No obvious changes in the transport of epimedin B were observed in the presence of verapamil and MK571.
CONCLUSIONS:
In summary, our results clearly demonstrate, for the first time, that poor bioavailability of these three prenylated flavonoids is the result of poor intrinsic permeability and efflux by apical efflux transporters.

Epimedin B1 Dilution Calculator

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Epimedin B1 Molarity Calculator

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Preparing Stock Solutions of Epimedin B1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2364 mL 6.182 mL 12.364 mL 24.728 mL 30.91 mL
5 mM 0.2473 mL 1.2364 mL 2.4728 mL 4.9456 mL 6.182 mL
10 mM 0.1236 mL 0.6182 mL 1.2364 mL 2.4728 mL 3.091 mL
50 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
100 mM 0.0124 mL 0.0618 mL 0.1236 mL 0.2473 mL 0.3091 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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