Hydrocinnamic acid

CAS# 501-52-0

Hydrocinnamic acid

Catalog No. BCN4057----Order now to get a substantial discount!

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Quality Control of Hydrocinnamic acid

Number of papers citing our products

Chemical structure

Hydrocinnamic acid

3D structure

Chemical Properties of Hydrocinnamic acid

Cas No. 501-52-0 SDF Download SDF
PubChem ID 107 Appearance Powder
Formula C9H10O2 M.Wt 150.2
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-phenylpropanoic acid
SMILES C1=CC=C(C=C1)CCC(=O)O
Standard InChIKey XMIIGOLPHOKFCH-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Hydrocinnamic acid

The herbs of Piper nigrum

Biological Activity of Hydrocinnamic acid

Description1. Hydrocinnamic acid inhibits the currents of WT and SQT3 syndrome-related mutants of Kir2.1 channel.

Hydrocinnamic acid Dilution Calculator

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Hydrocinnamic acid Molarity Calculator

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Preparing Stock Solutions of Hydrocinnamic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.6578 mL 33.2889 mL 66.5779 mL 133.1558 mL 166.4447 mL
5 mM 1.3316 mL 6.6578 mL 13.3156 mL 26.6312 mL 33.2889 mL
10 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
50 mM 0.1332 mL 0.6658 mL 1.3316 mL 2.6631 mL 3.3289 mL
100 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Hydrocinnamic acid

Hydrocinnamic Acid Inhibits the Currents of WT and SQT3 Syndrome-Related Mutants of Kir2.1 Channel.[Pubmed:28660286]

J Membr Biol. 2017 Oct;250(5):425-432.

Gain of function in mutations, D172N and E299V, of Kir2.1 will induce type III short QT syndrome. In our previous work, we had identified that a mixture of traditional Chinese medicine, styrax, is a blocker of Kir2.1. Here, we determined a monomer, Hydrocinnamic acid (HA), as the effective component from 18 compounds of styrax. Our data show that HA can inhibit the currents of Kir2.1 channel in both excised inside-out and whole-cell patch with the IC50 of 5.21 +/- 1.02 and 10.08 +/- 0.46 mM, respectively. The time course of HA blockage and washout are 2.3 +/- 0.6 and 10.5 +/- 2.6 s in the excised inside-out patch. Moreover, HA can also abolish the currents of D172N and E299V with the IC50 of 6.66 +/- 0.57 and 5.81 +/- 1.10 mM for D172N and E299V, respectively. Molecular docking results determine that HA binds with Kir2.1 at K182, K185, and K188, which are phosphatidylinositol 4,5-bisphosphate (PIP2) binding residues. Our results indicate that HA competes with PIP2 to bind with Kir2.1 and inhibits the currents.

Salt effect on phenolics and antioxidant activities of Tunisian and Canadian sweet marjoram (Origanum majorana L.) shoots.[Pubmed:22674342]

J Sci Food Agric. 2013 Jan 15;93(1):134-41.

BACKGROUND: Two varieties of Origanum majorana (Canadian and Tunisian) were evaluated for their phenolic, flavonoid and tannin contents, individual phenolic compounds and antioxidant activities under NaCl constraint. RESULTS: The results showed a significant variability in phenolic composition and antioxidant behavior between the two varieties under salt stress. The phenolic composition of methanolic extracts was determined by reversed-phase high-performance liquid chromatography. Amentoflavone was the predominant flavonoid compound; in addition, trans-2-Hydrocinnamic acid became the major phenolic acid with salt treatment of the Tunisian variety. In the control, Canadian variety extract was characterized by high levels of gallic acid and amentoflavone. However, under 75 mmol L(-1) NaCl, gallic acid content doubled, whereas amentoflavone content was maintained in the Canadian variety. Stimulation of phenolic acid biosynthesis was observed in these two varieties under salt treatment despite the fact that shoots of the Tunisian variety showed higher antioxidant activities compared to those from the Canadian variety. Tunisian O. majorana might have developed tolerance to salinity and avoided tissue damage by activating enzymes involved in the galactosylation of quercetin into quercetin-3-galactoside and quercetin-3-rhamnoside. CONCLUSION: Our results confirmed the tolerance of Tunisian O. majorana plants.

Description

Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.

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