Isocucurbitacin BCAS# 17278-28-3 |
- 3-epi-Isocucurbitacin B
Catalog No.:BCN9317
CAS No.:89647-62-1
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 17278-28-3 | SDF | Download SDF |
| PubChem ID | 5352014 | Appearance | Powder |
| Formula | C32H46O8 | M.Wt | 558.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(E,6R)-6-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-4,4,9,13,14-pentamethyl-2,11-dioxo-3,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate | ||
| SMILES | CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(=O)C(C4(C)C)O)C)C)C)O)O | ||
| Standard InChIKey | WTBZNVRBNJWSPF-DZEACCAPSA-N | ||
| Standard InChI | InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19,21-22,25-26,35,38-39H,11,14-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,26-,29+,30-,31+,32+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isocucurbitacin B has significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM. |
Isocucurbitacin B Dilution Calculator
Isocucurbitacin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7899 mL | 8.9493 mL | 17.8987 mL | 35.7974 mL | 44.7467 mL |
| 5 mM | 0.358 mL | 1.7899 mL | 3.5797 mL | 7.1595 mL | 8.9493 mL |
| 10 mM | 0.179 mL | 0.8949 mL | 1.7899 mL | 3.5797 mL | 4.4747 mL |
| 50 mM | 0.0358 mL | 0.179 mL | 0.358 mL | 0.7159 mL | 0.8949 mL |
| 100 mM | 0.0179 mL | 0.0895 mL | 0.179 mL | 0.358 mL | 0.4475 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Mudanpioside C
Catalog No.:BCN2798
CAS No.:172760-03-1
- Varespladib (LY315920)
Catalog No.:BCC2310
CAS No.:172732-68-2
- Senkyunolide S
Catalog No.:BCC9145
CAS No.:172723-28-3
- Fmoc-β-Homo-Val-OH
Catalog No.:BCC2626
CAS No.:172695-33-9
- Fosaprepitant
Catalog No.:BCC4281
CAS No.:172673-20-0
- Clemastanin A
Catalog No.:BCC8151
CAS No.:172670-47-2
- Eucalyptone
Catalog No.:BCN1111
CAS No.:172617-99-1
- Murrayamine E
Catalog No.:BCN7908
CAS No.:172617-68-4
- Naringin 4'-glucoside
Catalog No.:BCN8196
CAS No.:17257-21-5
- Senkyunolide R
Catalog No.:BCC9144
CAS No.:172549-37-0
- Eupatarone
Catalog No.:BCN7199
CAS No.:17249-61-5
- 9-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A
Catalog No.:BCN7671
CAS No.:172486-22-5
- H-Aib-OEt.HCl
Catalog No.:BCC2670
CAS No.:17288-15-2
- PP 1
Catalog No.:BCC3630
CAS No.:172889-26-8
- PP 2 (AG 1879)
Catalog No.:BCC3631
CAS No.:172889-27-9
- LY 272015 hydrochloride
Catalog No.:BCC7558
CAS No.:172895-15-7
- LY 266097 hydrochloride
Catalog No.:BCC7856
CAS No.:172895-39-5
- Isosinensetin
Catalog No.:BCN2919
CAS No.:17290-70-9
- PB 28 dihydrochloride
Catalog No.:BCC7411
CAS No.:172907-03-8
- FICZ
Catalog No.:BCC5513
CAS No.:172922-91-7
- Biorobin
Catalog No.:BCN4691
CAS No.:17297-56-2
- BWX 46
Catalog No.:BCC5865
CAS No.:172997-92-1
- Isoanthricin
Catalog No.:BCN3531
CAS No.:17301-70-5
- Poloxime
Catalog No.:BCC5307
CAS No.:17302-61-3
Bioassay-guided isolation and identification of cytotoxic compounds from Bolbostemma paniculatum.[Pubmed:25882313]
J Ethnopharmacol. 2015 Jul 1;169:18-23.
ETHNOPHARMACOLOGICAL RELEVANCE: Bolbostemma paniculatum (Maxim.) Franquet (B. paniculatum), also named "Tu-bei-mu" in Chinese folk medicines, has been described in application for the treatment of tumors, warts, inflammation and toxication in traditional Chinese medicinal books. The major constituents in B. paniculatum are triterpenoid saponins, which have been proved to possess dramatically cytotoxic activity and antivirus activity. The aim of this study is to isolate and identify the active triterpenoid saponin from the bulb of B. paniculatum by a bioassay-guided method. MATERIALS AND METHODS: Four cucurbitacine triterpenoid sapogenins and 11 triterpenoid saponins were isolated from the active EtOAc and n-BuOH extract of B. paniculatum by using bioassay-guided screening. Their structures were elucidated based on the spectroscopic methods and compared with published data. Cytotoxic activities of isolated compounds were determined by MTT assay. RESULTS: Four cucurbitacine triterpenoid sapogenins, Isocucurbitacin B(1), 23,24-dihydroIsocucurbitacin B(2), cucurbitacin E(3), 23,24-dihydrocucurbitacin E(4), and 11 triterpenoid saponins, tubeimosideI(5), tubeimoside III(6), tubeimoside V(7), dexylosyltubeimoside III(8), lobatoside C(9), tubeimoside A(10), tumeimoside B(11), lobatoside A(12), tubeimoside C(13), tubeimoside IV(14), 7beta,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-alpha-L-(4-acetyl)arabinopyra nosyl-(1-->2)-beta-D-glucopyranoside(15) were isolated from the active EtOAc and n-BuOH extracts. Of them, compounds 2, 4, 9 and 12 were firstly isolated from the Bolbostemma genus. MTT assay revealed that compounds 1, 3 and 4 had significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73muM. It is worth mentioning that compound 4s activities against the two cell lines are 12- and 8-fold that of the positive control drug (5-Fu). Whereas, the cyclic bisdesmosides 5-9 exerted significantly activities on BGC-823, HeLa, HT-29 and MCF-7 cancer cells with IC50 values ranging from 1.30 to 15.64muM. And 6s activities against the four cell lines are 6-, 3-, 10- and 16-fold that of 5-Fu and 8s activities against the four cell lines are 5-, 3-, 14- and 9-fold that of 5-Fu. CONCLUSION: The cytotoxic activity of the bulbs of B. paniculatum is mainly ascribable to cucurbitacine triterpenoid sapogenins (1-4) and the cyclic bisdesmosides (5-9). The cyclic bisdesmosides are the main anti-cancer active compounds of B. paniculatum. The above results provide scientific evidence to support, to some extent, the ethnomedicinal use of B. paniculatum as anticancer remedies in traditional Chinese medicine.
