IsolupalbigeninCAS# 162616-70-8 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 162616-70-8 | SDF | Download SDF |
| PubChem ID | 26238934 | Appearance | Powder |
| Formula | C25H26O5 | M.Wt | 406.48 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)chromen-4-one | ||
| SMILES | CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C(=CC(=C3CC=C(C)C)O)O)O)C | ||
| Standard InChIKey | FXJPTJQFJYNFKC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H26O5/c1-14(2)5-7-17-11-16(8-10-20(17)26)19-13-30-25-18(9-6-15(3)4)21(27)12-22(28)23(25)24(19)29/h5-6,8,10-13,26-28H,7,9H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). 2. Isolupalbigenin shows in vitro inhibitory activity toward human glyoxalase I. 3. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection. |
| Targets | NO | Antifection |
Isolupalbigenin Dilution Calculator
Isolupalbigenin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4601 mL | 12.3007 mL | 24.6015 mL | 49.2029 mL | 61.5036 mL |
| 5 mM | 0.492 mL | 2.4601 mL | 4.9203 mL | 9.8406 mL | 12.3007 mL |
| 10 mM | 0.246 mL | 1.2301 mL | 2.4601 mL | 4.9203 mL | 6.1504 mL |
| 50 mM | 0.0492 mL | 0.246 mL | 0.492 mL | 0.9841 mL | 1.2301 mL |
| 100 mM | 0.0246 mL | 0.123 mL | 0.246 mL | 0.492 mL | 0.615 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 3-Hydroxy-5,7-dimethoxy-3',4'-methylenedioxyflavan
Catalog No.:BCN1540
CAS No.:162602-04-2
- Broussoflavonol F
Catalog No.:BCN3571
CAS No.:162558-94-3
- Fmoc-Dap(Boc)-OH
Catalog No.:BCC3188
CAS No.:162558-25-0
- CDP 840 hydrochloride
Catalog No.:BCC7814
CAS No.:162542-90-7
- Salirasib
Catalog No.:BCC1918
CAS No.:162520-00-5
- Subelliptenone G
Catalog No.:BCN1720
CAS No.:162473-22-5
- VR23
Catalog No.:BCC6523
CAS No.:1624602-30-7
- Stilbostemin B
Catalog No.:BCN4697
CAS No.:162411-67-8
- GR 103691
Catalog No.:BCC6941
CAS No.:162408-66-4
- 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid
Catalog No.:BCC8628
CAS No.:162401-62-9
- Roflumilast
Catalog No.:BCN2182
CAS No.:162401-32-3
- 3-O-Methyl-Estrone
Catalog No.:BCC8640
CAS No.:1624-62-0
- Eriosemation
Catalog No.:BCN3738
CAS No.:162616-72-0
- Sorokinianin
Catalog No.:BCN6978
CAS No.:162616-73-1
- Temsirolimus
Catalog No.:BCC3678
CAS No.:162635-04-3
- AZD3759
Catalog No.:BCC6475
CAS No.:1626387-80-1
- AT 56
Catalog No.:BCC6036
CAS No.:162640-98-4
- HQL 79
Catalog No.:BCC7703
CAS No.:162641-16-9
- 6-Deoxyjacareubin
Catalog No.:BCN6573
CAS No.:16265-56-8
- Kaempferol tetraacetate
Catalog No.:BCN1721
CAS No.:16274-11-6
- 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran
Catalog No.:BCN1539
CAS No.:16274-33-2
- 1-Hydroxy-2-prenylnaphthalene
Catalog No.:BCN1722
CAS No.:16274-34-3
- AZD8186
Catalog No.:BCC6470
CAS No.:1627494-13-6
- LDN-214117
Catalog No.:BCC5528
CAS No.:1627503-67-6
Different antibacterial actions of isoflavones isolated from Erythrina poeppigiana against methicillin-resistant Staphylococcus aureus.[Pubmed:16910926]
Lett Appl Microbiol. 2006 Sep;43(3):243-8.
AIMS: To screen six isoflavones isolated from Erythrina poeppigiana (Leguminosae) for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). METHODS AND RESULTS: Stem bark of E. poeppigiana was macerated with acetone and the methylene chloride-soluble fraction of the residue was applied to repeated silica gel column chromatography and eluted. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by a broth dilution method. Inactive compounds that failed inhibiting bacterial growth at 25 microg ml(-1) were further investigated for their combination effects with methicillin and oxacillin. Of the isolated isoflavones, 5,7,4'-trihydroxy-8,3'-di(gamma,gamma-dimethylallyl)isoflavone (Isolupalbigenin) exhibited the highest anti-MRSA activity (MICs: 1.56-3.13 microg ml(-1); MBCs: 6.25-12.5 microg ml(-1)), followed by 5,7,4'-trihydroxy-6-gamma,gamma-dimethylallylisoflavone (erythrinin B). Inactive compounds were combined with methicillin or oxacillin, 5,4'-dihydroxy-(3'',4''-dihydro-3''-hydroxy)-2'',2''-dimethylpyrano[5'',6'':6,7]i soflavone (M-Wi-2) intensifying the susceptibility of MRSA strains to these antibiotics. In all but one strain, the MIC values of methicillin were reduced from > or =100 to 6.25-12.5 microg ml(-1) in the presence of M-Wi-2 (25 microg ml(-1)). CONCLUSIONS: Isoflavones from E. poeppigiana showed two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity. SIGNIFICANCE AND IMPACT OF THE STUDY: Isolupalbigenin and M-Wi-2 could lead to the development of compounds for new approaches against MRSA infection.
Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation.[Pubmed:27649772]
J Asian Nat Prod Res. 2017 May;19(5):510-518.
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), Isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 muM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 +/- 2.4, 66.9 +/- 1.8, and 55.4 +/- 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 +/- 0.7 to 18.0 +/- 1.7 muM).
Phenolic constituents from stem bark of Erythrina poeppigiana and their inhibitory activity on human glyoxalase I.[Pubmed:24756815]
J Nat Med. 2014 Jul;68(3):636-42.
A novel isoflavone, erythgianin A (1), along with nine known compounds 2-10, was isolated from the stem bark of Erythrina poeppigiana (Leguminosae). The unusual isoflavone structure of 1, possessing a highly oxidized 3'',4''-dihydroxy-2''-hydroxymethyl-2''-methyl-2'',3''-dihydropyrano substituent, was determined on the basis of spectroscopic analyses. All of the isolated compounds were evaluated for their in vitro inhibitory activity toward human glyoxalase I. Among the isolates, Isolupalbigenin (10) with two prenyl groups showed the highest inhibitory activity.
