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Isomucronulatol 7-O-glucoside

CAS# 94367-43-8

Isomucronulatol 7-O-glucoside

Catalog No. BCN3845----Order now to get a substantial discount!

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Isomucronulatol 7-O-glucoside: 5mg Please Inquire In Stock
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Chemical structure

Isomucronulatol 7-O-glucoside

3D structure

Chemical Properties of Isomucronulatol 7-O-glucoside

Cas No. 94367-43-8 SDF Download SDF
PubChem ID 125142 Appearance Powder
Formula C23H28O10 M.Wt 464.5
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5S,6R)-2-[[3-(2-hydroxy-3,4-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES COC1=C(C(=C(C=C1)C2CC3=C(C=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O)OC2)O)OC
Standard InChIKey SXHOGLPTLQBGDO-ZPHFBNLKSA-N
Standard InChI InChI=1S/C23H28O10/c1-29-15-6-5-14(18(25)22(15)30-2)12-7-11-3-4-13(8-16(11)31-10-12)32-23-21(28)20(27)19(26)17(9-24)33-23/h3-6,8,12,17,19-21,23-28H,7,9-10H2,1-2H3/t12?,17-,19-,20+,21-,23-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isomucronulatol 7-O-glucoside

The roots of Astragalus membranaceus

Biological Activity of Isomucronulatol 7-O-glucoside

DescriptionIsomucronulatol 7-O-β-D-glucoside shows anti-osteoarthritic effects, it reduced the expression of all OA-related molecules.
TargetsMMP13 | COX | TNF-α | p65 | IL Recepter
In vitro

Inhibition of Osteoarthritis-Related Molecules by Isomucronulatol 7-O-β-d-glucoside and Ecliptasaponin A in IL-1β-Stimulated Chondrosarcoma Cell Model.[Reference: WebLink]

Molecules, 2018, 23(11).

Osteoarthritis (OA) is the common form of arthritis and is characterized by disability and cartilage degradation. Although natural product extracts have been reported to have anti-osteoarthritic effects, the potential bioactivity of Ryupunghwan (RPH), a traditional Korean medicinal botanical formula that contains Astragalus membranaceus, Turnera diffusa, Achyranthes bidentata, Angelica gigas, Eclipta prostrata, Eucommia ulmoides, and Ilex paraguariensis, is not known well. Therefore, the inhibitory effects of single compounds isolated from RPH on the OA-related molecules were investigated using IL-1β-stimulated chondrosarcoma SW1353 (SW1353) cell model.
METHODS AND RESULTS:
Two bioactive compounds, isomucronulatol 7-O-β-D-glucoside (Isomucronulatol 7-O-glucoside, IMG) and ecliptasaponin A (ES) were isolated and purified from RPH using column chromatography, and then the structures were analyzed using ESI-MS, 1H-NMR, and 13C-NMR spectrum. The expression or amount of matrix metalloproteinase 13 (MMP13), COX1/2, TNF-α, IL-1β or p65 was determined by RT-PCR, Western blot, and enzyme-linked immunosorbent assay (ELISA). RPH pretreatment reduced the expression and amounts of MMP13, and the expression of collagen II, COX1/2, TNF-α, IL-1β or p65, which were increased in IL-1β-stimulated SW1353 cells. IMG reduced the expression of all OA-related molecules, but the observed inhibitory effect was less than that of RPH extract. The other single compound ES showed the reduced expression of all OA-related molecules, and the effect was stronger than that in IMG (approximately 100 fold). Combination pretreatment of both single components remarkably reduced the expression of MMP13, compared to each single component.
CONCLUSIONS:
These synergic effects may provide potential molecular modes of action for the anti-osteoarthritic effects of RPH observed in clinical and animal studies.

Isomucronulatol 7-O-glucoside Dilution Calculator

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Isomucronulatol 7-O-glucoside Molarity Calculator

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Preparing Stock Solutions of Isomucronulatol 7-O-glucoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1529 mL 10.7643 mL 21.5285 mL 43.0571 mL 53.8213 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL 8.6114 mL 10.7643 mL
10 mM 0.2153 mL 1.0764 mL 2.1529 mL 4.3057 mL 5.3821 mL
50 mM 0.0431 mL 0.2153 mL 0.4306 mL 0.8611 mL 1.0764 mL
100 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.4306 mL 0.5382 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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