MJ 15

Potent and selective CB1 antagonist CAS# 944154-76-1

MJ 15

Catalog No. BCC7852----Order now to get a substantial discount!

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MJ 15: 5mg $115 In Stock
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Quality Control of MJ 15

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Chemical structure

MJ 15

3D structure

Chemical Properties of MJ 15

Cas No. 944154-76-1 SDF Download SDF
PubChem ID 59377482 Appearance Powder
Formula C23H17Cl3N4O M.Wt 471.77
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
Chemical Name 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(pyridin-3-ylmethyl)pyrazole-3-carboxamide
SMILES CC1=C(N(N=C1C(=O)NCC2=CN=CC=C2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl
Standard InChIKey PJEIKJFNEFJFLA-UHFFFAOYSA-N
Standard InChI InChI=1S/C23H17Cl3N4O/c1-14-21(23(31)28-13-15-3-2-10-27-12-15)29-30(20-9-8-18(25)11-19(20)26)22(14)16-4-6-17(24)7-5-16/h2-12H,13H2,1H3,(H,28,31)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of MJ 15

DescriptionPotent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.

MJ 15 Dilution Calculator

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MJ 15 Molarity Calculator

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Preparing Stock Solutions of MJ 15

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1197 mL 10.5984 mL 21.1968 mL 42.3935 mL 52.9919 mL
5 mM 0.4239 mL 2.1197 mL 4.2394 mL 8.4787 mL 10.5984 mL
10 mM 0.212 mL 1.0598 mL 2.1197 mL 4.2394 mL 5.2992 mL
50 mM 0.0424 mL 0.212 mL 0.4239 mL 0.8479 mL 1.0598 mL
100 mM 0.0212 mL 0.106 mL 0.212 mL 0.4239 mL 0.5299 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on MJ 15

11-mJ, 15-Hz single-frequency diode-pumped Q-switched Er, Yb:phosphate glass laser.[Pubmed:18049580]

Opt Lett. 2001 Aug 15;26(16):1262-4.

A single-frequency diode-pumped Q-switched Er, Yb:phosphate glass laser that oscillates at an eye-safe 1.54etam wavelength has been developed for use in coherent Doppler lidar. A maximum TEM(00)-mode Q-switched output energy of 10.9 mJ and a relatively long pulse width of 228 ns were obtained at a repetition rate of 15 Hz by use of a modified 2-m-long telescopic cavity. Frequency stability of as high as +/-1.9-MHz standard deviation and a side-mode suppression ratio of more than 30 dB were also achieved.

K(alpha) x-ray emission characterization of 100 Hz, 15 mJ femtosecond laser system with high contrast ratio.[Pubmed:20052295]

Appl Phys B. 2008 Dec 12;94(4):569-575.

We report K(alpha) x-ray production with a high energy (110 mJ per pulse at 800 nm before compression/15 mJ at 400 nm after compression), high repetition rate (100 Hz), and high pulse contrast (better than 10(-9) at 400 nm) laser system. To develop laser-based x-ray sources for biomedical imaging requires to use high-energy and high-power ultra-fast laser system where compression is achieved under vacuum. Using this type of laser system, we demonstrate long-term stability of the x-ray yield, conversion efficiency higher than 1.5 x 10(-5) with a Mo target, and the x-ray spot size close to the optical focal spot. This high-repetition K(alpha) x-ray source can be very useful for x-ray phase-contrast imaging.

Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models.[Pubmed:20380831]

Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85.

MJ15, a novel cannabinoid CB(1) receptor selective antagonist was discovered. In receptor binding assays, MJ15 displayed a high affinity for rat cannabinoid CB(1) receptor (K(i)=27.2 pM, and IC(50)=118.9 pM), but a much lower affinity for rat cannabinoid CB(2) receptor (only 46% inhibition at 10 microM). At the cellular level, the IC(50) values against activation of cannabinoid CB(1) and CB(2) receptors induced by Win55212-2 in specially designed EGFP-CB(1)_U2OS and EGFP-CB(2)_U2OS cells were 0.11 microM and >10 microM, respectively. In addition, MJ15 dose-dependently blocked Win55212-2 mediated increase of intracellular Ca(2+) levels in hippocampal cells and reversed the inhibitory effects of cannabinoid CB(1) receptor agonist on forskolin-stimulated adenylyl cyclase activity in CHO cells expressing the human cannabinoid CB(1) receptor. In animal experiments, MJ15 demonstrated remarkable effects from 20 to 40 mg/kg, including promoted the small intestine peristalsis in ICR mice and inhibited food intake and body weight increase in diet-induced obesity (DIO) rat and mouse. 40 mg/kg MJ15 significantly reduced food intake at initial 2 weeks of treatment, prevented the increase of body weight and adipose by 46% and 28% respectively in DIO rats, and reduced body weight and adipose gain by 70% and 23% respectively in early onset obesity DIO mice after 4 weeks treatment. Meanwhile, dyslipidemia were ameliorated in both models. Taken together the in vitro and in vivo data, MJ15 is demonstrated to be a potent and selective cannabinoid CB(1) receptor antagonist and holds a prominent potency in obesity and dyslipidemia treatment.

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