KL 001CAS# 309928-48-1 |
Related Products
- Vatalanib (PTK787) 2HCl
Catalog No.:BCC1111
CAS No.:212141-51-0
- Cediranib (AZD217)
Catalog No.:BCC1121
CAS No.:288383-20-0
- Lenvatinib (E7080)
Catalog No.:BCC1172
CAS No.:417716-92-8
- Tivozanib (AV-951)
Catalog No.:BCC1179
CAS No.:475108-18-0
- Brivanib (BMS-540215)
Catalog No.:BCC1231
CAS No.:649735-46-6
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 309928-48-1 | SDF | Download SDF |
| PubChem ID | 2888648 | Appearance | Powder |
| Formula | C21H22N2O4S | M.Wt | 398.48 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol | ||
| Chemical Name | N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | ||
| SMILES | CS(=O)(=O)N(CC1=CC=CO1)CC(CN2C3=CC=CC=C3C4=CC=CC=C42)O | ||
| Standard InChIKey | OQAFDLPAPSSOHY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression. |
KL 001 Dilution Calculator
KL 001 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5095 mL | 12.5477 mL | 25.0954 mL | 50.1907 mL | 62.7384 mL |
| 5 mM | 0.5019 mL | 2.5095 mL | 5.0191 mL | 10.0381 mL | 12.5477 mL |
| 10 mM | 0.251 mL | 1.2548 mL | 2.5095 mL | 5.0191 mL | 6.2738 mL |
| 50 mM | 0.0502 mL | 0.251 mL | 0.5019 mL | 1.0038 mL | 1.2548 mL |
| 100 mM | 0.0251 mL | 0.1255 mL | 0.251 mL | 0.5019 mL | 0.6274 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Boc-Aib-OH
Catalog No.:BCC3148
CAS No.:30992-29-1
- SX 011
Catalog No.:BCC7731
CAS No.:309913-42-6
- Dauricinoline
Catalog No.:BCC8162
CAS No.:30984-80-6
- Vinyl Cinnamate
Catalog No.:BCN5041
CAS No.:3098-92-8
- GW791343 HCl
Catalog No.:BCC4974
CAS No.:309712-55-8
- 1,5-Dicaffeoylquinic acid
Catalog No.:BCN5913
CAS No.:30964-13-7
- 2-Amino-9H-fluoren-9-one
Catalog No.:BCC8545
CAS No.:3096-57-9
- Perillartine
Catalog No.:BCN8305
CAS No.:30950-27-7
- Doxifluridine
Catalog No.:BCC4903
CAS No.:3094-09-5
- Inauhzin
Catalog No.:BCC5146
CAS No.:309271-94-1
- Boc-Asp-OBzl
Catalog No.:BCC3363
CAS No.:30925-18-9
- Boc-N-Me-Phg-OH
Catalog No.:BCC3350
CAS No.:30925-11-2
New Products
- 3-(Boc-Amino)piperidine
Catalog No.:BCC8590
CAS No.:309956-78-3
- 7-O-Methylmangiferin
Catalog No.:BCN2804
CAS No.:31002-12-7
- 1-O-(3,4-Dimethoxybenzoyl)-beta-D-glucopyranose
Catalog No.:BCN3759
CAS No.:31002-27-4
- 7-Ethoxycoumarin
Catalog No.:BCN2708
CAS No.:31005-02-4
- Magnolin
Catalog No.:BCN5224
CAS No.:31008-18-1
- Fargesin
Catalog No.:BCN5022
CAS No.:31008-19-2
- Dihydrosphingosine
Catalog No.:BCC6778
CAS No.:3102-56-5
- Ceramide
Catalog No.:BCC2458
CAS No.:3102-57-6
- Echinophyllin C
Catalog No.:BCN5225
CAS No.:310433-44-4
- Spaglumic acid
Catalog No.:BCC6632
CAS No.:3106-85-2
- Cedeodarin
Catalog No.:BCN4784
CAS No.:31076-39-8
- Alytesin
Catalog No.:BCC7203
CAS No.:31078-12-3
Identification of small molecule activators of cryptochrome.[Pubmed:22798407]
Science. 2012 Aug 31;337(6098):1094-7.
Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock function might offer therapeutic approaches to such diseases, only a few compounds have been identified that selectively target core clock proteins. From an unbiased cell-based circadian phenotypic screen, we identified KL001, a small molecule that specifically interacts with cryptochrome (CRY). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In combination with mathematical modeling, our studies using KL001 revealed that CRY1 and CRY2 share a similar functional role in the period regulation. Furthermore, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
KL 001,309928-48-1,Natural Products,Transcription Factors, buy KL 001 , KL 001 supplier , purchase KL 001 , KL 001 cost , KL 001 manufacturer , order KL 001 , high purity KL 001
