Kuwanon B

CAS# 62949-78-4

Kuwanon B

2D Structure

Catalog No. BCX0747----Order now to get a substantial discount!

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3D structure

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Kuwanon B

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Chemical Properties of Kuwanon B

Cas No. 62949-78-4 SDF Download SDF
PubChem ID 44258295.0 Appearance Powder
Formula C25H24O6 M.Wt 420.45
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-2-(5-hydroxy-2,2-dimethylchromen-6-yl)-3-(3-methylbut-2-enyl)chromen-4-one
SMILES CC(=CCC1=C(OC2=CC(=CC(=C2C1=O)O)O)C3=C(C4=C(C=C3)OC(C=C4)(C)C)O)C
Standard InChIKey GHYDRKXFHRBWGZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C25H24O6/c1-13(2)5-6-17-23(29)21-18(27)11-14(26)12-20(21)30-24(17)16-7-8-19-15(22(16)28)9-10-25(3,4)31-19/h5,7-12,26-28H,6H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Kuwanon B Dilution Calculator

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Kuwanon B Molarity Calculator

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Preparing Stock Solutions of Kuwanon B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3784 mL 11.892 mL 23.784 mL 47.5681 mL 59.4601 mL
5 mM 0.4757 mL 2.3784 mL 4.7568 mL 9.5136 mL 11.892 mL
10 mM 0.2378 mL 1.1892 mL 2.3784 mL 4.7568 mL 5.946 mL
50 mM 0.0476 mL 0.2378 mL 0.4757 mL 0.9514 mL 1.1892 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4757 mL 0.5946 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Kuwanon B

Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism.[Pubmed:37499116]

J Nat Prod. 2023 Aug 25;86(8):2022-2030.

Kuwanons A (1) and B (2) are two natural prenylated flavones isolated from the root bark of Morus alba L. In this study, the first total syntheses of kuwanons A (1) and B (2) were achieved from a common intermediate with overall yields of 6.6% and 11.6%, respectively. Kuwanon B (2) exhibited antibacterial activity against Gram-positive bacteria and concentration-dependent bactericidal activity against Staphylococcus aureus bacteria. Preliminary mechanism of action studies suggested that this compound killed bacteria rapidly by disrupting bacterial membrane integrity.

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