LP 20 hydrochlorideSelective 5-HT7 ligand CAS# 1386928-34-2 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1386928-34-2 | SDF | Download SDF |
| PubChem ID | 22001617 | Appearance | Powder |
| Formula | C17H21ClN2O | M.Wt | 304.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 50 mM in water and to 100 mM in DMSO | ||
| Chemical Name | 1-[2-(4-methoxyphenyl)phenyl]piperazine;hydrochloride | ||
| SMILES | COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3.Cl | ||
| Standard InChIKey | KXZUJPBDJNUNCN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H20N2O.ClH/c1-20-15-8-6-14(7-9-15)16-4-2-3-5-17(16)19-12-10-18-11-13-19;/h2-9,18H,10-13H2,1H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively). |
LP 20 hydrochloride Dilution Calculator
LP 20 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2807 mL | 16.4037 mL | 32.8073 mL | 65.6146 mL | 82.0183 mL |
| 5 mM | 0.6561 mL | 3.2807 mL | 6.5615 mL | 13.1229 mL | 16.4037 mL |
| 10 mM | 0.3281 mL | 1.6404 mL | 3.2807 mL | 6.5615 mL | 8.2018 mL |
| 50 mM | 0.0656 mL | 0.3281 mL | 0.6561 mL | 1.3123 mL | 1.6404 mL |
| 100 mM | 0.0328 mL | 0.164 mL | 0.3281 mL | 0.6561 mL | 0.8202 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.[Pubmed:22738316]
J Med Chem. 2012 Jul 26;55(14):6375-80.
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT(7) affinities in the nanomolar range and >100-fold selectivity over 5-HT(1A) and adrenergic alpha(1) receptors. 1-[2-(4-Methoxyphenyl)phenyl]piperazine (9a) showed 5-HT(7) agonist properties in a guinea pig ileum assay but blocked 5-HT-mediated cAMP accumulation in 5-HT(7)-expressing HeLa cells.
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