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LP 20 hydrochloride

Selective 5-HT7 ligand CAS# 1386928-34-2

LP 20 hydrochloride

Catalog No. BCC6266----Order now to get a substantial discount!

Product Name & Size Price Stock
LP 20 hydrochloride: 5mg $104 In Stock
LP 20 hydrochloride: 10mg Please Inquire In Stock
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Chemical structure

LP 20 hydrochloride

3D structure

Chemical Properties of LP 20 hydrochloride

Cas No. 1386928-34-2 SDF Download SDF
PubChem ID 22001617 Appearance Powder
Formula C17H21ClN2O M.Wt 304.81
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 50 mM in water and to 100 mM in DMSO
Chemical Name 1-[2-(4-methoxyphenyl)phenyl]piperazine;hydrochloride
SMILES COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3.Cl
Standard InChIKey KXZUJPBDJNUNCN-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H20N2O.ClH/c1-20-15-8-6-14(7-9-15)16-4-2-3-5-17(16)19-12-10-18-11-13-19;/h2-9,18H,10-13H2,1H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of LP 20 hydrochloride

DescriptionLigand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).

LP 20 hydrochloride Dilution Calculator

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LP 20 hydrochloride Molarity Calculator

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Preparing Stock Solutions of LP 20 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2807 mL 16.4037 mL 32.8073 mL 65.6146 mL 82.0183 mL
5 mM 0.6561 mL 3.2807 mL 6.5615 mL 13.1229 mL 16.4037 mL
10 mM 0.3281 mL 1.6404 mL 3.2807 mL 6.5615 mL 8.2018 mL
50 mM 0.0656 mL 0.3281 mL 0.6561 mL 1.3123 mL 1.6404 mL
100 mM 0.0328 mL 0.164 mL 0.3281 mL 0.6561 mL 0.8202 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on LP 20 hydrochloride

Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.[Pubmed:22738316]

J Med Chem. 2012 Jul 26;55(14):6375-80.

Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT(7) affinities in the nanomolar range and >100-fold selectivity over 5-HT(1A) and adrenergic alpha(1) receptors. 1-[2-(4-Methoxyphenyl)phenyl]piperazine (9a) showed 5-HT(7) agonist properties in a guinea pig ileum assay but blocked 5-HT-mediated cAMP accumulation in 5-HT(7)-expressing HeLa cells.

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