A 1070722

Highly potent, selective GSK-3 inhibitor CAS# 1384424-80-9

A 1070722

Catalog No. BCC7933----Order now to get a substantial discount!

Product Name & Size Price Stock
A 1070722: 5mg $115 In Stock
A 1070722: 10mg Please Inquire In Stock
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Chemical structure

A 1070722

3D structure

Chemical Properties of A 1070722

Cas No. 1384424-80-9 SDF Download SDF
PubChem ID 49830684 Appearance Powder
Formula C17H13F3N4O2 M.Wt 362.31
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 83.33 mg/mL (230.00 mM; Need ultrasonic)
Chemical Name 1-(7-methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
SMILES COC1=CC2=NC=CC(=C2C=C1)NC(=O)NC3=CC=CC(=N3)C(F)(F)F
Standard InChIKey VQPBIJGXSXEOCU-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of A 1070722

DescriptionPotent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

A 1070722 Dilution Calculator

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A 1070722 Molarity Calculator

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Preparing Stock Solutions of A 1070722

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7601 mL 13.8003 mL 27.6007 mL 55.2013 mL 69.0017 mL
5 mM 0.552 mL 2.7601 mL 5.5201 mL 11.0403 mL 13.8003 mL
10 mM 0.276 mL 1.38 mL 2.7601 mL 5.5201 mL 6.9002 mL
50 mM 0.0552 mL 0.276 mL 0.552 mL 1.104 mL 1.38 mL
100 mM 0.0276 mL 0.138 mL 0.276 mL 0.552 mL 0.69 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.

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