A 1070722Highly potent, selective GSK-3 inhibitor CAS# 1384424-80-9 |
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Quality Control & MSDS
3D structure
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| Cas No. | 1384424-80-9 | SDF | Download SDF |
| PubChem ID | 49830684 | Appearance | Powder |
| Formula | C17H13F3N4O2 | M.Wt | 362.31 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 83.33 mg/mL (230.00 mM; Need ultrasonic) | ||
| Chemical Name | 1-(7-methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea | ||
| SMILES | COC1=CC2=NC=CC(=C2C=C1)NC(=O)NC3=CC=CC(=N3)C(F)(F)F | ||
| Standard InChIKey | VQPBIJGXSXEOCU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant. |
A 1070722 Dilution Calculator
A 1070722 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7601 mL | 13.8003 mL | 27.6007 mL | 55.2013 mL | 69.0017 mL |
| 5 mM | 0.552 mL | 2.7601 mL | 5.5201 mL | 11.0403 mL | 13.8003 mL |
| 10 mM | 0.276 mL | 1.38 mL | 2.7601 mL | 5.5201 mL | 6.9002 mL |
| 50 mM | 0.0552 mL | 0.276 mL | 0.552 mL | 1.104 mL | 1.38 mL |
| 100 mM | 0.0276 mL | 0.138 mL | 0.276 mL | 0.552 mL | 0.69 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.
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