CYM 9484Potent NPY Y2 receptor antagonist CAS# 1383478-94-1 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 1383478-94-1 | SDF | Download SDF |
| PubChem ID | 66561564 | Appearance | Powder |
| Formula | C27H31N3O3S2 | M.Wt | 509.63 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | N-[4-(dimethylsulfamoyl)phenyl]-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide | ||
| SMILES | CN(C)S(=O)(=O)C1=CC=C(C=C1)NC(=S)N2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O | ||
| Standard InChIKey | VAUKHARIAMDAGF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C27H31N3O3S2/c1-29(2)35(32,33)25-15-13-24(14-16-25)28-26(34)30-19-17-23(18-20-30)27(31,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,31H,17-20H2,1-2H3,(H,28,34) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent neuropeptide Y (NPY) Y2 receptor antagonist (IC50 = 19 nM). |
CYM 9484 Dilution Calculator
CYM 9484 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9622 mL | 9.811 mL | 19.6221 mL | 39.2442 mL | 49.0552 mL |
| 5 mM | 0.3924 mL | 1.9622 mL | 3.9244 mL | 7.8488 mL | 9.811 mL |
| 10 mM | 0.1962 mL | 0.9811 mL | 1.9622 mL | 3.9244 mL | 4.9055 mL |
| 50 mM | 0.0392 mL | 0.1962 mL | 0.3924 mL | 0.7849 mL | 0.9811 mL |
| 100 mM | 0.0196 mL | 0.0981 mL | 0.1962 mL | 0.3924 mL | 0.4906 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.[Pubmed:22607676]
Bioorg Med Chem Lett. 2012 Jun 15;22(12):3916-20.
Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC(50) values of 19 nM and 12 nM respectively.
CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.
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