Hedycoronen ACAS# 1383441-73-3 |
Quality Control & MSDS
3D structure
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| Cas No. | 1383441-73-3 | SDF | Download SDF |
| PubChem ID | 56931827 | Appearance | Powder |
| Formula | C21H30O3 | M.Wt | 330.46 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(E)-2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2-methoxy-2H-furan-5-one | ||
| SMILES | CC1(CCCC2(C1CCC(=C)C2C=CC3=CC(OC3=O)OC)C)C | ||
| Standard InChIKey | BQAWJLFWEBGZIH-MZBNRDNVSA-N | ||
| Standard InChI | InChI=1S/C21H30O3/c1-14-7-10-17-20(2,3)11-6-12-21(17,4)16(14)9-8-15-13-18(23-5)24-19(15)22/h8-9,13,16-18H,1,6-7,10-12H2,2-5H3/b9-8+/t16-,17-,18?,21+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The rhizomes of Hedychium coronarium.
| Description | 1. Hedycoronen A and hedycoronen B are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC(50) values of 46.0±1.3 and 12.7±0.3 uM, suggests that they have the potential anti-inflammatory benefits. |
| Targets | TNF-α | IL Receptor |
Hedycoronen A Dilution Calculator
Hedycoronen A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0261 mL | 15.1304 mL | 30.2608 mL | 60.5217 mL | 75.6521 mL |
| 5 mM | 0.6052 mL | 3.0261 mL | 6.0522 mL | 12.1043 mL | 15.1304 mL |
| 10 mM | 0.3026 mL | 1.513 mL | 3.0261 mL | 6.0522 mL | 7.5652 mL |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6052 mL | 1.2104 mL | 1.513 mL |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.6052 mL | 0.7565 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.[Pubmed:22293485]
Chem Pharm Bull (Tokyo). 2012;60(2):246-50.
The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1-3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1+/-0.2 to 9.1+/-0.3 muM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-alpha (TNF-alpha) production with IC(50) values of 46.0+/-1.3 and 12.7+/-0.3 muM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.
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