Tinospinoside C

CAS# 1383977-51-2

Tinospinoside C

Catalog No. BCN6925----Order now to get a substantial discount!

Product Name & Size Price Stock
Tinospinoside C: 5mg $886 In Stock
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Tinospinoside C: 500mg Please Inquire Please Inquire
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Quality Control of Tinospinoside C

Number of papers citing our products

Chemical structure

Tinospinoside C

3D structure

Chemical Properties of Tinospinoside C

Cas No. 1383977-51-2 SDF Download SDF
PubChem ID 56951689 Appearance Powder
Formula C27H36O12 M.Wt 552.58
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (2S,4aR,6aR,9R,10aR,10bS)-2-(furan-3-yl)-4a-hydroxy-6a,10b-dimethyl-4-oxo-9-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,5,6,9,10,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
SMILES CC12CCC3(C(=O)OC(CC3(C1CC(C=C2C(=O)OC)OC4C(C(C(C(O4)CO)O)O)O)C)C5=COC=C5)O
Standard InChIKey SFZVAPHHIUDDEI-BAXBFVPBSA-N
Standard InChI InChI=1S/C27H36O12/c1-25-5-6-27(34)24(33)39-16(13-4-7-36-12-13)10-26(27,2)18(25)9-14(8-15(25)22(32)35-3)37-23-21(31)20(30)19(29)17(11-28)38-23/h4,7-8,12,14,16-21,23,28-31,34H,5-6,9-11H2,1-3H3/t14-,16-,17+,18+,19+,20-,21+,23+,25-,26-,27-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tinospinoside C

The roots of Tinospora sagittata (Oliv.) Gagnep.

Biological Activity of Tinospinoside C

Description1. Tinospinoside C shows inhibitory activities of NO production with the IC(50) value of 218 uM.
TargetsNO

Tinospinoside C Dilution Calculator

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Tinospinoside C Molarity Calculator

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Preparing Stock Solutions of Tinospinoside C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8097 mL 9.0485 mL 18.0969 mL 36.1939 mL 45.2423 mL
5 mM 0.3619 mL 1.8097 mL 3.6194 mL 7.2388 mL 9.0485 mL
10 mM 0.181 mL 0.9048 mL 1.8097 mL 3.6194 mL 4.5242 mL
50 mM 0.0362 mL 0.181 mL 0.3619 mL 0.7239 mL 0.9048 mL
100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.3619 mL 0.4524 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tinospinoside C

Clerodane diterpenoids from Tinospora sagittata (Oliv.) Gagnep.[Pubmed:21969117]

Planta Med. 2012 Jan;78(1):82-5.

Three new clerodane diterpene glycosides, tinospinosides A (1), B (2), and C (3) were isolated from the roots of Tinospora sagittata (Oliv.) Gagnep. Their structures were determined to be (2 S,4a R,6a R,9 R,10a S,10b S)-2-(3-furanyl)-9-( beta-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-6a,10b-dimethyl-4- oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (1), (2 S,4a S,6a R,9 R,10a R,10b S)-2-(3-furanyl)-9-( beta-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b -dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (2) and (2 S,4a R,6a R,9 R,10a R,10b S)-2-(3-furanyl)-9-( beta-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b -dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (3), by various spectroscopic analyses, chemical reactions, and computer-assisted calculations. The inhibitory activities of NO production by these compounds and their chemical derivatives in lipopolysaccharide and TNF gamma-activated macrophage-like cell line J774.1 were tested. Tinospin A, 12- EPI-tinospin A, tinospinoside B, and Tinospinoside C showed inhibitory activities of NO production with the IC(50) values of 162, 182, 290, and 218 microM, respectively.

New clerodane diterpenes from Tinospora sagittata var. yunnanensis.[Pubmed:24634023]

Planta Med. 2014 Mar;80(5):419-25.

Four new clerodane diterpenes, namely sagittatayunnanosides A-D (1-4), were isolated from the roots of Tinospora sagittata var. yunnanensis, together with two known compounds, Tinospinoside C (5) and tinospinoside E (6). The structures of the four new compounds were well elucidated by extensive analyses of the MS, IR, and 1D and 2D NMR data. The cytotoxic and antifouling activities of compounds 1-6 were evaluated.

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