LucidadiolCAS# 252351-95-4 |
Quality Control & MSDS
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| Cas No. | 252351-95-4 | SDF | Download SDF |
| PubChem ID | 10789991 | Appearance | Powder |
| Formula | C30H48O3 | M.Wt | 456.71 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S,5R,10S,13R,14R,17R)-3-hydroxy-17-[(E,2R)-7-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,3,5,6,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-7-one | ||
| SMILES | CC(CCC=C(C)CO)C1CCC2(C1(CCC3=C2C(=O)CC4C3(CCC(C4(C)C)O)C)C)C | ||
| Standard InChIKey | AZPOACUDFJKUHJ-GPEQXWBKSA-N | ||
| Standard InChI | InChI=1S/C30H48O3/c1-19(18-31)9-8-10-20(2)21-11-16-30(7)26-22(12-15-29(21,30)6)28(5)14-13-25(33)27(3,4)24(28)17-23(26)32/h9,20-21,24-25,31,33H,8,10-18H2,1-7H3/b19-9+/t20-,21-,24+,25+,28-,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Lucidadiol possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. 2. Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM. 3. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1. |
| Targets | AChR | HSV |
Lucidadiol Dilution Calculator
Lucidadiol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1896 mL | 10.9479 mL | 21.8957 mL | 43.7915 mL | 54.7393 mL |
| 5 mM | 0.4379 mL | 2.1896 mL | 4.3791 mL | 8.7583 mL | 10.9479 mL |
| 10 mM | 0.219 mL | 1.0948 mL | 2.1896 mL | 4.3791 mL | 5.4739 mL |
| 50 mM | 0.0438 mL | 0.219 mL | 0.4379 mL | 0.8758 mL | 1.0948 mL |
| 100 mM | 0.0219 mL | 0.1095 mL | 0.219 mL | 0.4379 mL | 0.5474 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes.[Pubmed:25577284]
Phytochemistry. 2015 Feb;110:133-9.
Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3beta-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3beta-acetyloxy-11beta,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3beta-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3beta-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-Lucidadiol, 11beta-hydroxy-Lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3beta-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 muM.
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.[Pubmed:21924611]
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7.
Two new lanostane triterpenes, named methyl ganoderate A acetonide (1) and n-butyl ganoderate H (2), were isolated from the fruiting bodies of Ganoderma lucidum together with 16 known compounds (3-18). Extensive spectroscopic and chemical studies established the structures of these compounds as methyl 7beta,15alpha-isopropylidenedioxy-3,11,23-trioxo-5alpha-lanost-8-en-26-oate (1) and n-butyl 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-5alpha-lanost-8-en-26-oate (2). Because new compounds exhibiting specific anti-acetylcholinesterase activity are being sought as possible drug candidates for the treatment of Alzheimer's and related neurodegenerative diseases, compounds 1-18 were examined for their inhibitory activities against acetylcholinesterase and butyrylcholinesterase. All of the compounds exhibited moderate acetylcholinesterase-inhibitory activity, with IC(50) values ranging from 9.40 to 31.03muM. In contrast, none of the compounds except Lucidadiol (13) and lucidenic acid N (14) exhibited butyrylcholinesterase-inhibitory activity at concentrations up to 200muM. These results indicate that these lanostane triterpenes are preferential inhibitors of acetylcholinesterase and may be suitable drug candidates.
Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi.[Pubmed:12628419]
Fitoterapia. 2003 Feb;74(1-2):177-80.
Ganodermadiol, Lucidadiol and applanoxidic acid G were isolated as first triterpenes from the European Basidiomycete Ganoderma pfeifferi. The compounds show antiviral activity against influenza virus type A and HSV type 1.
