LuteosporinCAS# 2530-39-4 |
Quality Control & MSDS
3D structure
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| Cas No. | 2530-39-4 | SDF | Download SDF |
| PubChem ID | 135965857 | Appearance | Powder |
| Formula | C28H18O12 | M.Wt | 546.44 |
| Type of Compound | Quinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R)-8-[(3R)-9,10-dihydroxy-3-methyl-1,6,7-trioxo-3,4-dihydrobenzo[g]isochromen-8-yl]-9,10-dihydroxy-3-methyl-3,4-dihydrobenzo[g]isochromene-1,6,7-trione | ||
| SMILES | CC1CC2=C(C(=C3C(=C2)C(=O)C(=O)C(=C3O)C4=C(C5=C(C6=C(CC(OC6=O)C)C=C5C(=O)C4=O)O)O)O)C(=O)O1 | ||
| Standard InChIKey | QSOHSHLFJFCXEH-HTQZYQBOSA-N | ||
| Standard InChI | InChI=1S/C28H18O12/c1-7-3-9-5-11-15(21(31)13(9)27(37)39-7)23(33)17(25(35)19(11)29)18-24(34)16-12(20(30)26(18)36)6-10-4-8(2)40-28(38)14(10)22(16)32/h5-8,31-34H,3-4H2,1-2H3/t7-,8-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Luteosporin and xanthomegnin are pigments, they are suspected to be genotoxic carcinogens. 2. Luteosporin inhibits porcine pancreatic phospholipase A2 (PLA2) with Ki values of 12.8 microM. |
Luteosporin Dilution Calculator
Luteosporin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.83 mL | 9.1501 mL | 18.3003 mL | 36.6005 mL | 45.7507 mL |
| 5 mM | 0.366 mL | 1.83 mL | 3.6601 mL | 7.3201 mL | 9.1501 mL |
| 10 mM | 0.183 mL | 0.915 mL | 1.83 mL | 3.6601 mL | 4.5751 mL |
| 50 mM | 0.0366 mL | 0.183 mL | 0.366 mL | 0.732 mL | 0.915 mL |
| 100 mM | 0.0183 mL | 0.0915 mL | 0.183 mL | 0.366 mL | 0.4575 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.[Pubmed:6722817]
Cancer Res. 1984 Jul;44(7):2918-23.
Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6- dimethoxysterigmatocystin , versicolorins A and B, averufin , xanthomegnin , Luteosporin , and chrysazin , as well as by the carcinogenic myocotoxins , aflatoxin B1, sterigmatocystin, luteoskyrin , ochratoxin A, azaserine, mitomycin C, and actinomycin D. The positive results with compounds of unknown carcinogenicity suggest that they are possibly genotoxic carcinogens. The carcinogenic mycotoxins, penicillic acid, patulin, griseofulvin, and rugulosin , which did not elicit repair synthesis may be nongenotoxic carcinogens.
Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties.[Pubmed:3839502]
J Antibiot (Tokyo). 1985 Jun;38(6):706-12.
Plastatin and the known fungal metabolite, Luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A2 (PLA2). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and Luteosporin inhibited pancreatic PLA2 competitively with Ki values of 0.89 microM and 12.8 microM, respectively. PLA2 preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and Luteosporin.
Genotoxicity of quinone pigments from pathogenic fungi.[Pubmed:6621592]
Mutat Res. 1983 Oct;122(1):29-34.
The genotoxicity and mutagenicity of several kinds of quinone pigments from pathogenic fungi were examined by means of the hepatocyte primary culture (HPC)/DNA repair test and of Ames test with TA98 and TA100. Clear genotoxicity of the two quinone chemicals, xanthomegnin and Luteosporin were observed in the HPC/DNA repair test, though definite mutagenicity was not detected in the Salmonella microsome test. These two pigments are thus suspected to be genotoxic carcinogens.
