MDL 73005EF hydrochloridePotent and selective 5-HT1A partial agonist CAS# 102908-60-1 |
- Acetyl-Calpastatin (184-210) (human)
Catalog No.:BCC2350
CAS No.:123714-50-1
- CA 074
Catalog No.:BCC1141
CAS No.:134448-10-5
- PD 151746
Catalog No.:BCC5485
CAS No.:179461-52-0
- Odanacatib (MK-0822)
Catalog No.:BCC1197
CAS No.:603139-19-1
- E-64-c
Catalog No.:BCC3588
CAS No.:76684-89-4
- SID 26681509
Catalog No.:BCC2362
CAS No.:958772-66-2
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 102908-60-1 | SDF | Download SDF |
| PubChem ID | 56972149 | Appearance | Powder |
| Formula | C20H27ClN2O4 | M.Wt | 394.9 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 25 mM in water | ||
| Chemical Name | 8-[2-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride | ||
| SMILES | C1CCC2(C1)CC(=O)N(C(=O)C2)CCNCC3COC4=CC=CC=C4O3.Cl | ||
| Standard InChIKey | UEDYXFOPCMTXEH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H26N2O4.ClH/c23-18-11-20(7-3-4-8-20)12-19(24)22(18)10-9-21-13-15-14-25-16-5-1-2-6-17(16)26-15;/h1-2,5-6,15,21H,3-4,7-14H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and selective 5-HT1A receptor antagonist. Has partial agonist properties. |
MDL 73005EF hydrochloride Dilution Calculator
MDL 73005EF hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5323 mL | 12.6614 mL | 25.3229 mL | 50.6457 mL | 63.3072 mL |
| 5 mM | 0.5065 mL | 2.5323 mL | 5.0646 mL | 10.1291 mL | 12.6614 mL |
| 10 mM | 0.2532 mL | 1.2661 mL | 2.5323 mL | 5.0646 mL | 6.3307 mL |
| 50 mM | 0.0506 mL | 0.2532 mL | 0.5065 mL | 1.0129 mL | 1.2661 mL |
| 100 mM | 0.0253 mL | 0.1266 mL | 0.2532 mL | 0.5065 mL | 0.6331 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Pexidartinib (PLX3397)
Catalog No.:BCC6405
CAS No.:1029044-16-3
- 17-Hydroxy sprengerinin C
Catalog No.:BCN2755
CAS No.:1029017-75-1
- Lycopsamine
Catalog No.:BCN1999
CAS No.:10285-07-1
- Intermedine
Catalog No.:BCN1997
CAS No.:10285-06-0
- MLN8237 (Alisertib)
Catalog No.:BCC2166
CAS No.:1028486-01-2
- Ganolactone B
Catalog No.:BCN2872
CAS No.:1028449-53-7
- Moracin P
Catalog No.:BCN3289
CAS No.:102841-46-3
- Mulberroside C
Catalog No.:BCN6344
CAS No.:102841-43-0
- Mulberroside A
Catalog No.:BCN6343
CAS No.:102841-42-9
- D-Pinitol
Catalog No.:BCN5842
CAS No.:10284-63-6
- BEZ235 Tosylate
Catalog No.:BCC1416
CAS No.:1028385-32-1
- VUF 10460
Catalog No.:BCC6285
CAS No.:1028327-66-3
- Scutellaric acid
Catalog No.:BCN5843
CAS No.:102919-76-6
- INCB28060
Catalog No.:BCC3793
CAS No.:1029712-80-8
- Trelagliptin succinate
Catalog No.:BCC2015
CAS No.:1029877-94-8
- H-DL-Phg-OH
Catalog No.:BCC3317
CAS No.:103-01-5
- Monobenzone
Catalog No.:BCC3818
CAS No.:103-16-2
- Methyl cinnamate
Catalog No.:BCN5043
CAS No.:103-26-4
- Ethyl cinnamate
Catalog No.:BCN5044
CAS No.:103-36-6
- Benzyl cinnamate
Catalog No.:BCN5042
CAS No.:103-41-3
- Scutebarbatine M
Catalog No.:BCN8327
CAS No.:960302-92-5
- N-Methylbenzylamine
Catalog No.:BCN1790
CAS No.:103-67-3
- Phenylacetic Acid
Catalog No.:BCC8349
CAS No.:103-82-2
- 4'-Methylacetanilide
Catalog No.:BCC8714
CAS No.:103-89-9
Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious spontaneously hypertensive rats.[Pubmed:1362161]
Eur J Pharmacol. 1992 Nov 17;223(2-3):133-41.
The effects of pretreatment with the potent and selective 5-HT1A receptor ligand, MDL 73005EF, on the cardiovascular responses to administration of the 5-HT1A receptor agonists, 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT), flesinoxan and 5-methylurapidil were studied in conscious spontaneously hypertensive rats (SHR) and compared with those of putative 5-HT1A receptor antagonists. MDL 7300EF (0.1-3 mg/kg) induced a dose-dependent but transient decrease in mean arterial pressure (MAP). Pretreatment with doses of 1 or 3 mg/kg MDL 73005EF significantly inhibited the hypotensive and bradycardiac effects of 8-OH-DPAT (0.03-1 mg/kg). Pretreatment with 1 mg/kg MDL 73005EF similarly reduced the hypotensive actions of flesinoxan (0.3-1 mg/kg) and 5-methylurapidil (0.1 mg/kg). In contrast, MDL 73005EF did not significantly affect the decrease in blood pressure induced by administration of 0.01 mg/kg clonidine, 0.3 mg/kg hydralazine or 0.2 mg/kg nifedipine. The effect of 8-OH-DPAT (0.1 mg/kg) on MAP was also reduced by pretreatment with 1 mg/kg BMY 7378, buspirone or pindolol, but not NAN 190 or spiperone. BMY 7378, NAN 190, pindolol and spiperone induced a significant decrease in blood pressure. To rule out the possibility that the reduced baseline may have influenced responses to 8-OH-DPAT, we showed that pretreatment with the vasodilator, hydralazine (0.3 mg/kg), had no effect on the MAP response to 8-OH-DPAT although it significantly reduced MAP. We conclude that MDL 73005EF acts as a mixed agonist/antagonist at 5-HT1A receptors since it caused a decrease in blood pressure, but also reduced the cardiovascular responses to the 5-HT1A receptor agonists, 8-OH-DPAT, flesinoxan and 5-methylurapidil.
Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice.[Pubmed:1893914]
Eur J Pharmacol. 1991 Apr 24;196(3):291-8.
The actions of 5-hydroxytryptamine (5-HT) and the 5-HT1A receptor ligand MDL 73005EF on neuronal activity in the CA1 region of rat hippocampal slices in vitro were recorded using intra- and extracellular recording techniques. 5-HT (1-30 microM) hyperpolarised the pyramidal neurones in a concentration-dependent manner and reduced membrane resistance and action potential after-hyperpolarisations (AHPs). MDL 73005EF (1-30 microM) had no clear effects on membrane potential, membrane resistance or AHPs. However, prior application of 3 microM MDL 73005EF to the slices for 10-60 min antagonised the hyperpolarisation induced by 30 microM 5-HT but not the reduction in spike AHP or the hyperpolarisation induced by the GABAB receptor agonist baclofen. MDL 73005EF and the 5-HT1A/2 receptor antagonist spiperone (both 3 microM) reduced the frequency and amplitude of spontaneous inhibitory (bicuculline-sensitive) postsynaptic potentials. Extracellular recordings of population action potentials revealed that MDL 73005EF did not prevent the induction or maintenance of hippocampal long-term potentiation or exhibit local anaesthetic properties. It is concluded that MDL 73005EF is an antagonist at 5-HT1A receptors on hippocampal CA1 pyramidal neurones.
Effects of MDL 73005EF on central pre- and postsynaptic 5-HT1A receptor function in the rat in vivo.[Pubmed:1964908]
Eur J Pharmacol. 1990 Dec 4;191(3):391-400.
The effects of MDL 73005EF (8-[2-(2,3-dihydro-1,4-benzodioxin-2-yl)methylamino]-8- azaspiro[4,5]decan-7,9-dione methyl sulphonate), a novel selective 5-HT1A receptor ligand with putative anxiolytic properties, were explored using models of central pre- and postsynaptic 5-HT1A receptor function in the male rat. MDL 73005EF dose dependently decreased the hippocampal 5-HT output measured by in vivo microdialysis in chloral hydrate-anaesthetised rats and this response was antagonised by the 5-HT1A/B receptor antagonist, pindolol. Local administration of MDL 73005EF had no effect on the hippocampal 5-HT output. MDL 73005EF failed to alter basal plasma adrenocorticotropin (ACTH) levels but, in common with pindolol, attenuated the ACTH response to the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In contrast to 8-OH-DPAT, MDL 73005EF significantly increased plasma prolactin but apparently not through a 5-HT receptor-mediated mechanism. The results indicate that MDL 73005EF possesses mixed 5-HT1A receptor agonist/antagonist properties, acting as an agonist at presynaptic 5-HT1A receptors controlling 5-HT release and as an antagonist at postsynaptic 5-HT1A receptors mediating ACTH release.
