Scutellaric acid

CAS# 102919-76-6

Scutellaric acid

2D Structure

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Scutellaric acid

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Chemical Properties of Scutellaric acid

Cas No. 102919-76-6 SDF Download SDF
PubChem ID 190461 Appearance Powder
Formula C30H48O4 M.Wt 472.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4aS,6aR,6aS,6bR,9S,10R,12aR,14bR)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1)C)C(=O)O)C
Standard InChIKey PGOYMURMZNDHNS-XXIVSGBYSA-N
Standard InChI InChI=1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21?,22-,23-,26+,27-,28-,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Scutellaric acid

The herb of Scutellaria barbata D. Don

Scutellaric acid Dilution Calculator

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Scutellaric acid Molarity Calculator

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Preparing Stock Solutions of Scutellaric acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1155 mL 10.5775 mL 21.1551 mL 42.3101 mL 52.8877 mL
5 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
10 mM 0.2116 mL 1.0578 mL 2.1155 mL 4.231 mL 5.2888 mL
50 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4231 mL 0.5289 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Scutellaric acid

New phenolics from the root of Scutellaria prostrata JACQ. ex BENTH.[Pubmed:25040064]

Nat Prod Res. 2014;28(20):1685-90.

Scutellaria prostrata (Lamiaceae), a perennial herb growing as a lonely species in Kashmir, Himalayas, was subjected to repetitive column and flash chromatographic isolation for its chemical documentation-cum-bioevaluation. The methanolic extract of S.prostrata afforded the isolation of ten compounds (1-10), including two new compounds - scutellapbiflavanone (1) and scutellaprostin M (2). The known compounds were found to be scutellarin (3), hispidulin-7-O-beta-D-glucopyranoside (4), baicalin (5), wogonoside (6), scutellaprostin C (7), acetoside (8), martynoside (9) and Scutellaric acid-3-O-beta-D-glucopyranoside (10). Isolation of biflavonoids, phenolics and phenylethanoid compounds from S. prostrata seals a deal of chemotaxonomic importance of this particular species. The characterisation of the compounds was achieved by (1)H, (13)C, (1)H-(1)H DFQ COSY, HMBC, HSQC, HMQC and ROESY NMR experiments. All the compounds were tested for antioxidant, antimicrobial and cytotoxic activities.

Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.[Pubmed:12946428]

Phytochemistry. 2003 Sep;64(1):293-302.

Coussaric acid (1), a triterpenoid based on an ursane skeleton, and an oleanane-type triterpene acid, 3-epi-spathodic acid (2), as well as four known compounds, barbinervic acid, Scutellaric acid, stigmasterol and stigmasterol glucoside, have been isolated from an EtOAc-soluble extract of the stems of Coussarea brevicaulis. The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic investigation, and single-crystal X-ray crystallography was used to confirm the structure of 1. The absolute stereochemistry of 1 was established by chemical transformations and by the Mosher ester procedure. The potential of the isolates and chemical transformation products to induce quinone reductase was evaluated in mouse Hepa lclc7 hepatoma cells.

Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.[Pubmed:19555121]

J Nat Prod. 2009 Jun;72(6):983-7.

Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2'-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, Scutellaric acid, pomolic acid, ursolic acid, beta-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro.

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