Mc-MMAETubulin inhibitor CAS# 863971-24-8 |
2D Structure
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Quality Control & MSDS
3D structure
Package In Stock
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Cas No. | 863971-24-8 | SDF | Download SDF |
PubChem ID | 59168780 | Appearance | Powder |
Formula | C49H78N6O10 | M.Wt | 911.18 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | Maleimidocaproyl-monomethylauristatin E | ||
Solubility | DMSO : ≥ 51 mg/mL (55.97 mM) *"≥" means soluble, but saturation unknown. | ||
Chemical Name | 6-(2,5-dioxopyrrol-1-yl)-N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylhexanamide | ||
SMILES | CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)CCCCCN3C(=O)C=CC3=O | ||
Standard InChIKey | UGJOTJHSQWBROP-AXJCKIDNSA-N | ||
Standard InChI | InChI=1S/C49H78N6O10/c1-13-32(6)44(37(64-11)29-41(59)54-28-20-23-36(54)46(65-12)33(7)47(61)50-34(8)45(60)35-21-16-14-17-22-35)53(10)49(63)42(30(2)3)51-48(62)43(31(4)5)52(9)38(56)24-18-15-19-27-55-39(57)25-26-40(55)58/h14,16-17,21-22,25-26,30-34,36-37,42-46,60H,13,15,18-20,23-24,27-29H2,1-12H3,(H,50,61)(H,51,62)/t32-,33+,34+,36-,37+,42-,43-,44-,45+,46+/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate (ADC).In Vitro:Synthesis of maleimidocaproyl-MMAE (mc-MMAE) requires the addition of maleimidocaproic acid to a solution of MMAE in dichloromethane followed by the addition of diethyl cyanophosphonate and diisopropylethylamine[1]. References: |
Mc-MMAE Dilution Calculator
Mc-MMAE Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.0975 mL | 5.4874 mL | 10.9748 mL | 21.9496 mL | 27.4369 mL |
5 mM | 0.2195 mL | 1.0975 mL | 2.195 mL | 4.3899 mL | 5.4874 mL |
10 mM | 0.1097 mL | 0.5487 mL | 1.0975 mL | 2.195 mL | 2.7437 mL |
50 mM | 0.0219 mL | 0.1097 mL | 0.2195 mL | 0.439 mL | 0.5487 mL |
100 mM | 0.011 mL | 0.0549 mL | 0.1097 mL | 0.2195 mL | 0.2744 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Monomethyl auristatin D (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAE is a protective group (maleimidocaproyl) -conjugated MMAE.
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