Mcl1-IN-1Myeloid cell factor 1 inhibitor CAS# 713492-66-1 |
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| Cas No. | 713492-66-1 | SDF | Download SDF |
| PubChem ID | 2966040 | Appearance | Powder |
| Formula | C23H18ClN3O4 | M.Wt | 435.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 50 mg/mL (114.72 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[2-[(5-chloro-8-hydroxyquinolin-7-yl)-(pyridin-2-ylamino)methyl]phenoxy]acetic acid | ||
| SMILES | C1=CC=C(C(=C1)C(C2=CC(=C3C=CC=NC3=C2O)Cl)NC4=CC=CC=N4)OCC(=O)O | ||
| Standard InChIKey | VMEDTSNKTYMQLG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H18ClN3O4/c24-17-12-16(23(30)22-14(17)7-5-11-26-22)21(27-19-9-3-4-10-25-19)15-6-1-2-8-18(15)31-13-20(28)29/h1-12,21,30H,13H2,(H,25,27)(H,28,29) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Mcl1-IN-1 Dilution Calculator
Mcl1-IN-1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2943 mL | 11.4716 mL | 22.9431 mL | 45.8863 mL | 57.3579 mL |
| 5 mM | 0.4589 mL | 2.2943 mL | 4.5886 mL | 9.1773 mL | 11.4716 mL |
| 10 mM | 0.2294 mL | 1.1472 mL | 2.2943 mL | 4.5886 mL | 5.7358 mL |
| 50 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 0.9177 mL | 1.1472 mL |
| 100 mM | 0.0229 mL | 0.1147 mL | 0.2294 mL | 0.4589 mL | 0.5736 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mcl1-IN-1 is a small molecule, potent and selective inhibitor of myeloid cell factor 1 (Mcl-1) with an IC50 value of 2.4 μM [1].
Mcl1-IN-1 has been reported to potently inhibit Mcl-1 which acted as an important therapeutic target for the treatment of non-solid tumor and solid tumor malignancies with an IC50 value of 2.4 μM. The inhibition ability of Mcl1-IN-1 to Mcl-1 was 40-fold more than Bcl-xL of which IC50 is 100 μM. Mcl1-IN-1 has the favorable physicochemical properties, for example, lack of any apparent toxicophores [1].
References:
[1] Richard DJ1, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1; 21(21):6642-9.
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Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).
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