Salaspermic acidCAS# 71247-78-4 |
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| Cas No. | 71247-78-4 | SDF | Download SDF |
| PubChem ID | 44593364 | Appearance | Powder |
| Formula | C30H48O4 | M.Wt | 472.71 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,4S,5R,8S,11R,13R,14S,17R,18S,21S,24R)-21-hydroxy-5,8,11,14,17,24-hexamethyl-22-oxahexacyclo[19.2.1.01,18.04,17.05,14.08,13]tetracosane-11-carboxylic acid | ||
| SMILES | CC1C23CCC4C(C2CCC1(OC3)O)(CCC5(C4(CCC6(C5CC(CC6)(C)C(=O)O)C)C)C)C | ||
| Standard InChIKey | ZXENWDWQTWYUGY-UUZWCOCASA-N | ||
| Standard InChI | InChI=1S/C30H48O4/c1-19-29-9-7-20-26(4,21(29)8-10-30(19,33)34-18-29)14-16-28(6)22-17-25(3,23(31)32)12-11-24(22,2)13-15-27(20,28)5/h19-22,33H,7-18H2,1-6H3,(H,31,32)/t19-,20+,21+,22-,24-,25-,26-,27-,28+,29+,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The stem barks of Kokoona ochracea.
| Description | 1. Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. |
| Targets | HIV |
Salaspermic acid Dilution Calculator
Salaspermic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1155 mL | 10.5773 mL | 21.1546 mL | 42.3092 mL | 52.8865 mL |
| 5 mM | 0.4231 mL | 2.1155 mL | 4.2309 mL | 8.4618 mL | 10.5773 mL |
| 10 mM | 0.2115 mL | 1.0577 mL | 2.1155 mL | 4.2309 mL | 5.2887 mL |
| 50 mM | 0.0423 mL | 0.2115 mL | 0.4231 mL | 0.8462 mL | 1.0577 mL |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2115 mL | 0.4231 mL | 0.5289 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Studies on triterpenoids of total glucosides of tripterygium wilfordii].[Pubmed:7720147]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Dec;16(6):466-8.
Three more triterpenoids were isolated from total glucosides of tripterygium wilfordii (T1). T16 and T17 were identified as Salaspermic acid and as wilforlide B. T18 was a new compound. The structure of T18 was determined, as 3-oxo-22 alpha-hydroxy-delta 12-oleanen-29-oic acid by detail spectroscopic and chemical analysis, and named triptotriterpenonic acid A.
Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.[Pubmed:8158155]
J Nat Prod. 1994 Jan;57(1):1-8.
Tingenone[1],20-hydroxy-20-epi-tingenone[2],celastrol[ 3], and Salaspermic acid [4] have been isolated from Kokoona ochracea stem bark. The quinone-methide triterpenes 1-3 exhibited strong but non-specific in vitro cytotoxicity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell lines. Salaspermic acid [4] was not active in all the cancer cell lines used in this investigation. 13C-nmr spectra assignments for Salaspermic acid have been accomplished through the application of 1D and 2D nmr spectral techniques, and 13C-nmr assignments for celastrol [3] have been revised.
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